ASXL1

 

Full name: ASXL transcriptional regulator 1 Alias Symbol: KIAA0978
Type: protein-coding gene Cytoband: 20q11.21
Entrez ID: 171023 HGNC ID: HGNC:18318 Ensembl Gene: ENSG00000171456 OMIM ID: 612990
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ASXL1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ASXL1 171023 212237_at 0.5638 0.0538
GSE20347 ASXL1 171023 212234_at 0.3440 0.0018
GSE23400 ASXL1 171023 212237_at 0.4452 0.0000
GSE26886 ASXL1 171023 212234_at 0.2968 0.1198
GSE29001 ASXL1 171023 212234_at 0.6907 0.0010
GSE38129 ASXL1 171023 212234_at 0.1385 0.3204
GSE45670 ASXL1 171023 212234_at -0.1481 0.3302
GSE53622 ASXL1 171023 45537 0.2228 0.0051
GSE53624 ASXL1 171023 45537 0.4415 0.0000
GSE63941 ASXL1 171023 212237_at 0.6606 0.0492
GSE77861 ASXL1 171023 212237_at 0.2410 0.1420
GSE97050 ASXL1 171023 A_33_P3436316 0.0735 0.8337
SRP007169 ASXL1 171023 RNAseq 0.2310 0.5823
SRP008496 ASXL1 171023 RNAseq 0.7993 0.0335
SRP064894 ASXL1 171023 RNAseq 0.8070 0.0000
SRP133303 ASXL1 171023 RNAseq 0.2251 0.0287
SRP159526 ASXL1 171023 RNAseq 0.4824 0.1258
SRP193095 ASXL1 171023 RNAseq 0.5340 0.0000
SRP219564 ASXL1 171023 RNAseq 0.5305 0.0102
TCGA ASXL1 171023 RNAseq -0.0377 0.4015

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ASXL1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ASXL1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ASXL1 171023 15 0 15
GSE20123 ASXL1 171023 15 0 15
GSE43470 ASXL1 171023 12 0 31
GSE46452 ASXL1 171023 29 0 30
GSE47630 ASXL1 171023 24 1 15
GSE54993 ASXL1 171023 0 18 52
GSE54994 ASXL1 171023 26 1 26
GSE60625 ASXL1 171023 0 0 11
GSE74703 ASXL1 171023 11 0 25
GSE74704 ASXL1 171023 10 0 10
TCGA ASXL1 171023 49 1 46

Total number of gains: 191; Total number of losses: 21; Total Number of normals: 276.  

 

Somatic mutations of ASXL1:

 

Generating mutation plots.

 

Highly correlated genes for ASXL1:

 

Showing top 20/1309 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ASXL1IFT800.796937303
ASXL1CPNE80.792914303
ASXL1SLC7A6OS0.789441303
ASXL1MED100.784749303
ASXL1RICTOR0.756868404
ASXL1CEP410.750642303
ASXL1N4BP2L20.7488303
ASXL1AGTRAP0.741626303
ASXL1DGCR20.740627303
ASXL1SSBP40.734145303
ASXL1PET1170.726623303
ASXL1PAPOLG0.725062303
ASXL1RNF1660.721691303
ASXL1WDR810.721311404
ASXL1SFT2D30.719642303
ASXL1GRAMD40.718467303
ASXL1PDP10.717062303
ASXL1GOLPH30.714952404
ASXL1TAF4B0.710525505
ASXL1DCUN1D20.708521404

For details and further investigation, click here