DDX27

 

Full name: DEAD-box helicase 27 Alias Symbol: dJ686N3.1|DRS1
Type: protein-coding gene Cytoband: 20q13.13
Entrez ID: 55661 HGNC ID: HGNC:15837 Ensembl Gene: ENSG00000124228 OMIM ID: 616621
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of DDX27:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DDX27 55661 215693_x_at 0.7533 0.1306
GSE20347 DDX27 55661 215693_x_at 0.4015 0.0004
GSE23400 DDX27 55661 215693_x_at 0.2973 0.0000
GSE26886 DDX27 55661 215693_x_at 0.5418 0.0020
GSE29001 DDX27 55661 215693_x_at 0.5818 0.0024
GSE38129 DDX27 55661 215693_x_at 0.4138 0.0002
GSE45670 DDX27 55661 215693_x_at 0.4284 0.0016
GSE53622 DDX27 55661 35924 0.3571 0.0000
GSE53624 DDX27 55661 35924 0.6266 0.0000
GSE63941 DDX27 55661 215693_x_at 0.6199 0.0446
GSE77861 DDX27 55661 221780_s_at 0.4851 0.0046
GSE97050 DDX27 55661 A_23_P40194 0.2973 0.3094
SRP007169 DDX27 55661 RNAseq 1.3103 0.0045
SRP008496 DDX27 55661 RNAseq 1.4350 0.0001
SRP064894 DDX27 55661 RNAseq 0.6848 0.0001
SRP133303 DDX27 55661 RNAseq 0.5108 0.0000
SRP159526 DDX27 55661 RNAseq 0.4752 0.0538
SRP193095 DDX27 55661 RNAseq 0.4946 0.0000
SRP219564 DDX27 55661 RNAseq 0.5422 0.0339
TCGA DDX27 55661 RNAseq 0.1789 0.0002

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by DDX27 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DDX27:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DDX27 55661 16 2 12
GSE20123 DDX27 55661 16 2 12
GSE43470 DDX27 55661 12 0 31
GSE46452 DDX27 55661 29 0 30
GSE47630 DDX27 55661 24 1 15
GSE54993 DDX27 55661 0 17 53
GSE54994 DDX27 55661 26 1 26
GSE60625 DDX27 55661 0 0 11
GSE74703 DDX27 55661 10 0 26
GSE74704 DDX27 55661 12 0 8
TCGA DDX27 55661 46 3 47

Total number of gains: 191; Total number of losses: 26; Total Number of normals: 271.  

 

Somatic mutations of DDX27:

 

Generating mutation plots.

 

Highly correlated genes for DDX27:

 

Showing top 20/1128 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DDX27PET1170.832294505
DDX27MRPS50.766873404
DDX27DGCR20.748764303
DDX27RAE10.73817212012
DDX27YWHAG0.735803605
DDX27DNTTIP10.73579808
DDX27NDRG30.734717303
DDX27SLC7A6OS0.7332505
DDX27CSE1L0.72862511011
DDX27CYTH30.725764403
DDX27CENPBD10.725203404
DDX27EIF3C0.723441303
DDX27SFR10.722474403
DDX27DCUN1D20.712023303
DDX27DDX550.711388706
DDX27FYN0.711063303
DDX27YTHDF10.71088112011
DDX27MRGBP0.71013411010
DDX27TOP10.708955908
DDX27TEX2610.702982303

For details and further investigation, click here