| Full name: dehydrogenase/reductase 2 | Alias Symbol: HEP27|SDR25C1 | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 10202 | HGNC ID: HGNC:18349 | Ensembl Gene: ENSG00000100867 | OMIM ID: 615194 |
| Drug and gene relationship at DGIdb | |||
Expression of DHRS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DHRS2 | 10202 | 206463_s_at | 0.4676 | 0.3272 | |
| GSE20347 | DHRS2 | 10202 | 206463_s_at | 0.3174 | 0.1081 | |
| GSE23400 | DHRS2 | 10202 | 206463_s_at | 0.2218 | 0.1574 | |
| GSE26886 | DHRS2 | 10202 | 206463_s_at | 0.1786 | 0.2850 | |
| GSE29001 | DHRS2 | 10202 | 206463_s_at | 0.4362 | 0.1401 | |
| GSE38129 | DHRS2 | 10202 | 206463_s_at | 0.1606 | 0.2936 | |
| GSE45670 | DHRS2 | 10202 | 206463_s_at | 1.0491 | 0.1526 | |
| GSE63941 | DHRS2 | 10202 | 206463_s_at | 1.4573 | 0.2667 | |
| GSE77861 | DHRS2 | 10202 | 206463_s_at | -0.0142 | 0.9314 | |
| GSE97050 | DHRS2 | 10202 | A_23_P321501 | 0.0910 | 0.6490 | |
| SRP133303 | DHRS2 | 10202 | RNAseq | 5.9416 | 0.0000 | |
| TCGA | DHRS2 | 10202 | RNAseq | -0.1514 | 0.7607 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DHRS2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DHRS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DHRS2 | 10202 | 8 | 1 | 21 | |
| GSE20123 | DHRS2 | 10202 | 8 | 1 | 21 | |
| GSE43470 | DHRS2 | 10202 | 7 | 2 | 34 | |
| GSE46452 | DHRS2 | 10202 | 17 | 2 | 40 | |
| GSE47630 | DHRS2 | 10202 | 11 | 10 | 19 | |
| GSE54993 | DHRS2 | 10202 | 3 | 11 | 56 | |
| GSE54994 | DHRS2 | 10202 | 18 | 5 | 30 | |
| GSE60625 | DHRS2 | 10202 | 0 | 2 | 9 | |
| GSE74703 | DHRS2 | 10202 | 6 | 2 | 28 | |
| GSE74704 | DHRS2 | 10202 | 3 | 1 | 16 | |
| TCGA | DHRS2 | 10202 | 27 | 14 | 55 |
Total number of gains: 108; Total number of losses: 51; Total Number of normals: 329.
Somatic mutations of DHRS2:
Generating mutation plots.
Highly correlated genes for DHRS2:
Showing top 20/101 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DHRS2 | PINX1 | 0.770791 | 3 | 0 | 3 |
| DHRS2 | GRK4 | 0.758944 | 3 | 0 | 3 |
| DHRS2 | NPY2R | 0.757467 | 3 | 0 | 3 |
| DHRS2 | TMEM52 | 0.729859 | 3 | 0 | 3 |
| DHRS2 | CRYGC | 0.722887 | 3 | 0 | 3 |
| DHRS2 | RNF151 | 0.718407 | 3 | 0 | 3 |
| DHRS2 | SH2D5 | 0.713428 | 3 | 0 | 3 |
| DHRS2 | NKAIN4 | 0.70755 | 4 | 0 | 4 |
| DHRS2 | TMEM179 | 0.707234 | 3 | 0 | 3 |
| DHRS2 | ISLR2 | 0.701493 | 3 | 0 | 3 |
| DHRS2 | CPNE9 | 0.70118 | 3 | 0 | 3 |
| DHRS2 | C1QTNF6 | 0.700795 | 3 | 0 | 3 |
| DHRS2 | SEC14L4 | 0.698228 | 3 | 0 | 3 |
| DHRS2 | CDH23 | 0.696673 | 3 | 0 | 3 |
| DHRS2 | MYH7B | 0.692277 | 3 | 0 | 3 |
| DHRS2 | GAST | 0.686905 | 4 | 0 | 3 |
| DHRS2 | ATP2B2 | 0.686305 | 4 | 0 | 3 |
| DHRS2 | FERD3L | 0.684918 | 3 | 0 | 3 |
| DHRS2 | CHRD | 0.684853 | 3 | 0 | 3 |
| DHRS2 | AGER | 0.682352 | 3 | 0 | 3 |
For details and further investigation, click here
