| Full name: gastrin | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 2520 | HGNC ID: HGNC:4164 | Ensembl Gene: ENSG00000184502 | OMIM ID: 137250 |
| Drug and gene relationship at DGIdb | |||
GAST involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04971 | Gastric acid secretion |
Expression of GAST:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GAST | 2520 | 208138_at | 0.1556 | 0.7042 | |
| GSE20347 | GAST | 2520 | 208138_at | 0.2336 | 0.1053 | |
| GSE23400 | GAST | 2520 | 208138_at | -0.0663 | 0.2093 | |
| GSE26886 | GAST | 2520 | 208138_at | 0.0905 | 0.6187 | |
| GSE29001 | GAST | 2520 | 208138_at | -0.0569 | 0.7449 | |
| GSE38129 | GAST | 2520 | 208138_at | 0.1184 | 0.3747 | |
| GSE45670 | GAST | 2520 | 208138_at | 0.2635 | 0.0188 | |
| GSE53622 | GAST | 2520 | 70435 | 0.7899 | 0.0000 | |
| GSE53624 | GAST | 2520 | 70435 | 1.1716 | 0.0000 | |
| GSE63941 | GAST | 2520 | 208138_at | 0.5950 | 0.1170 | |
| GSE77861 | GAST | 2520 | 208138_at | 0.5072 | 0.2400 | |
| GSE97050 | GAST | 2520 | A_23_P159191 | -0.0884 | 0.7141 | |
| SRP007169 | GAST | 2520 | RNAseq | 6.2132 | 0.0000 | |
| TCGA | GAST | 2520 | RNAseq | 3.8886 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by GAST expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GAST:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GAST | 2520 | 6 | 2 | 22 | |
| GSE20123 | GAST | 2520 | 6 | 2 | 22 | |
| GSE43470 | GAST | 2520 | 1 | 2 | 40 | |
| GSE46452 | GAST | 2520 | 34 | 0 | 25 | |
| GSE47630 | GAST | 2520 | 8 | 1 | 31 | |
| GSE54993 | GAST | 2520 | 3 | 4 | 63 | |
| GSE54994 | GAST | 2520 | 8 | 5 | 40 | |
| GSE60625 | GAST | 2520 | 4 | 0 | 7 | |
| GSE74703 | GAST | 2520 | 1 | 1 | 34 | |
| GSE74704 | GAST | 2520 | 4 | 1 | 15 | |
| TCGA | GAST | 2520 | 23 | 7 | 66 |
Total number of gains: 98; Total number of losses: 25; Total Number of normals: 365.
Somatic mutations of GAST:
Generating mutation plots.
Highly correlated genes for GAST:
Showing top 20/349 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GAST | AGAP2 | 0.770886 | 3 | 0 | 3 |
| GAST | MYLK3 | 0.75434 | 3 | 0 | 3 |
| GAST | TCHHL1 | 0.71526 | 3 | 0 | 3 |
| GAST | DHRS2 | 0.686905 | 4 | 0 | 3 |
| GAST | MAGEA8 | 0.686485 | 3 | 0 | 3 |
| GAST | PRKAR1B | 0.680628 | 6 | 0 | 6 |
| GAST | ZNF221 | 0.678141 | 3 | 0 | 3 |
| GAST | LRRC10 | 0.674976 | 3 | 0 | 3 |
| GAST | ZNF114 | 0.671229 | 3 | 0 | 3 |
| GAST | SLC18A3 | 0.667208 | 4 | 0 | 4 |
| GAST | NLRP5 | 0.665946 | 4 | 0 | 3 |
| GAST | LRTM2 | 0.665818 | 3 | 0 | 3 |
| GAST | SHARPIN | 0.660567 | 3 | 0 | 3 |
| GAST | BAHCC1 | 0.659687 | 5 | 0 | 4 |
| GAST | AANAT | 0.654381 | 4 | 0 | 3 |
| GAST | FOXJ1 | 0.654297 | 3 | 0 | 3 |
| GAST | FRMD1 | 0.653224 | 5 | 0 | 3 |
| GAST | CEACAM19 | 0.652128 | 7 | 0 | 7 |
| GAST | SV2C | 0.650633 | 4 | 0 | 4 |
| GAST | TMEM59L | 0.643188 | 3 | 0 | 3 |
For details and further investigation, click here
