| Full name: SH2 domain containing 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p36.12 | ||
| Entrez ID: 400745 | HGNC ID: HGNC:28819 | Ensembl Gene: ENSG00000189410 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of SH2D5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH2D5 | 400745 | 230973_at | 0.7003 | 0.1886 | |
| GSE26886 | SH2D5 | 400745 | 230973_at | 0.4409 | 0.0393 | |
| GSE45670 | SH2D5 | 400745 | 230973_at | 0.9749 | 0.0032 | |
| GSE53622 | SH2D5 | 400745 | 19428 | 1.1936 | 0.0000 | |
| GSE53624 | SH2D5 | 400745 | 19428 | 1.4099 | 0.0000 | |
| GSE63941 | SH2D5 | 400745 | 230973_at | -0.9027 | 0.0415 | |
| GSE77861 | SH2D5 | 400745 | 230973_at | 0.1387 | 0.1940 | |
| GSE97050 | SH2D5 | 400745 | A_24_P686965 | 0.6423 | 0.2959 | |
| SRP007169 | SH2D5 | 400745 | RNAseq | 2.4939 | 0.0166 | |
| SRP133303 | SH2D5 | 400745 | RNAseq | 4.0962 | 0.0000 | |
| SRP159526 | SH2D5 | 400745 | RNAseq | 4.1486 | 0.0000 | |
| SRP219564 | SH2D5 | 400745 | RNAseq | 2.5682 | 0.0106 | |
| TCGA | SH2D5 | 400745 | RNAseq | 2.0617 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by SH2D5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SH2D5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH2D5 | 400745 | 0 | 5 | 25 | |
| GSE20123 | SH2D5 | 400745 | 0 | 4 | 26 | |
| GSE43470 | SH2D5 | 400745 | 0 | 8 | 35 | |
| GSE46452 | SH2D5 | 400745 | 5 | 1 | 53 | |
| GSE47630 | SH2D5 | 400745 | 8 | 3 | 29 | |
| GSE54993 | SH2D5 | 400745 | 3 | 1 | 66 | |
| GSE54994 | SH2D5 | 400745 | 11 | 4 | 38 | |
| GSE60625 | SH2D5 | 400745 | 0 | 0 | 11 | |
| GSE74703 | SH2D5 | 400745 | 0 | 5 | 31 | |
| GSE74704 | SH2D5 | 400745 | 0 | 0 | 20 | |
| TCGA | SH2D5 | 400745 | 9 | 23 | 64 |
Total number of gains: 36; Total number of losses: 54; Total Number of normals: 398.
Somatic mutations of SH2D5:
Generating mutation plots.
Highly correlated genes for SH2D5:
Showing top 20/513 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH2D5 | CDH4 | 0.774662 | 3 | 0 | 3 |
| SH2D5 | FMNL1 | 0.750308 | 3 | 0 | 3 |
| SH2D5 | BOP1 | 0.736106 | 3 | 0 | 3 |
| SH2D5 | DHRS2 | 0.713428 | 3 | 0 | 3 |
| SH2D5 | ZFPM1 | 0.71332 | 3 | 0 | 3 |
| SH2D5 | STRIP2 | 0.713176 | 5 | 0 | 5 |
| SH2D5 | APLN | 0.704177 | 3 | 0 | 3 |
| SH2D5 | RUNX1-IT1 | 0.702899 | 4 | 0 | 4 |
| SH2D5 | NOC4L | 0.701303 | 6 | 0 | 6 |
| SH2D5 | IL24 | 0.693898 | 6 | 0 | 5 |
| SH2D5 | TNFRSF12A | 0.689921 | 8 | 0 | 7 |
| SH2D5 | SPRED3 | 0.68272 | 3 | 0 | 3 |
| SH2D5 | CSMD2 | 0.682189 | 3 | 0 | 3 |
| SH2D5 | C16orf74 | 0.679959 | 6 | 0 | 5 |
| SH2D5 | SPOCD1 | 0.679689 | 7 | 0 | 6 |
| SH2D5 | PLEC | 0.678848 | 6 | 0 | 6 |
| SH2D5 | CLCN6 | 0.678757 | 3 | 0 | 3 |
| SH2D5 | HOMER3 | 0.678038 | 9 | 0 | 8 |
| SH2D5 | CLDN14 | 0.677613 | 3 | 0 | 3 |
| SH2D5 | UBASH3B | 0.677449 | 3 | 0 | 3 |
For details and further investigation, click here
