| Full name: dolichyldiphosphatase 1 | Alias Symbol: LSFR2 | ||
| Type: protein-coding gene | Cytoband: 9q34.11 | ||
| Entrez ID: 57171 | HGNC ID: HGNC:29565 | Ensembl Gene: ENSG00000167130 | OMIM ID: 614516 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DOLPP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DOLPP1 | 57171 | 221817_at | 0.0710 | 0.8741 | |
| GSE20347 | DOLPP1 | 57171 | 221817_at | 0.0084 | 0.9398 | |
| GSE23400 | DOLPP1 | 57171 | 221817_at | 0.0715 | 0.1941 | |
| GSE26886 | DOLPP1 | 57171 | 221817_at | -0.5404 | 0.0027 | |
| GSE29001 | DOLPP1 | 57171 | 221817_at | -0.1233 | 0.5558 | |
| GSE38129 | DOLPP1 | 57171 | 221817_at | 0.0341 | 0.8013 | |
| GSE45670 | DOLPP1 | 57171 | 221817_at | 0.1300 | 0.3227 | |
| GSE53622 | DOLPP1 | 57171 | 162780 | 0.2104 | 0.0983 | |
| GSE53624 | DOLPP1 | 57171 | 162780 | 0.2580 | 0.0012 | |
| GSE63941 | DOLPP1 | 57171 | 221817_at | 0.7648 | 0.0065 | |
| GSE77861 | DOLPP1 | 57171 | 221817_at | 0.0217 | 0.8923 | |
| GSE97050 | DOLPP1 | 57171 | A_23_P386764 | 0.3305 | 0.2807 | |
| SRP007169 | DOLPP1 | 57171 | RNAseq | -0.1991 | 0.5952 | |
| SRP008496 | DOLPP1 | 57171 | RNAseq | -0.4797 | 0.0289 | |
| SRP064894 | DOLPP1 | 57171 | RNAseq | 0.5954 | 0.0270 | |
| SRP133303 | DOLPP1 | 57171 | RNAseq | 0.2653 | 0.2510 | |
| SRP159526 | DOLPP1 | 57171 | RNAseq | 0.0896 | 0.6990 | |
| SRP193095 | DOLPP1 | 57171 | RNAseq | -0.2766 | 0.0509 | |
| SRP219564 | DOLPP1 | 57171 | RNAseq | -0.1716 | 0.7574 | |
| TCGA | DOLPP1 | 57171 | RNAseq | 0.2187 | 0.0045 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DOLPP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DOLPP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DOLPP1 | 57171 | 6 | 9 | 15 | |
| GSE20123 | DOLPP1 | 57171 | 6 | 9 | 15 | |
| GSE43470 | DOLPP1 | 57171 | 5 | 8 | 30 | |
| GSE46452 | DOLPP1 | 57171 | 6 | 13 | 40 | |
| GSE47630 | DOLPP1 | 57171 | 3 | 16 | 21 | |
| GSE54993 | DOLPP1 | 57171 | 3 | 3 | 64 | |
| GSE54994 | DOLPP1 | 57171 | 11 | 8 | 34 | |
| GSE60625 | DOLPP1 | 57171 | 0 | 0 | 11 | |
| GSE74703 | DOLPP1 | 57171 | 5 | 6 | 25 | |
| GSE74704 | DOLPP1 | 57171 | 3 | 7 | 10 | |
| TCGA | DOLPP1 | 57171 | 27 | 25 | 44 |
Total number of gains: 75; Total number of losses: 104; Total Number of normals: 309.
Somatic mutations of DOLPP1:
Generating mutation plots.
Highly correlated genes for DOLPP1:
Showing top 20/319 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DOLPP1 | AP2S1 | 0.713054 | 4 | 0 | 3 |
| DOLPP1 | ALG14 | 0.685383 | 4 | 0 | 3 |
| DOLPP1 | CSNK1G1 | 0.683461 | 5 | 0 | 5 |
| DOLPP1 | SEC24C | 0.680684 | 3 | 0 | 3 |
| DOLPP1 | ATXN7L3 | 0.668636 | 5 | 0 | 5 |
| DOLPP1 | FAM83B | 0.667187 | 4 | 0 | 3 |
| DOLPP1 | SPIN4 | 0.662503 | 3 | 0 | 3 |
| DOLPP1 | ZDHHC12 | 0.655233 | 9 | 0 | 6 |
| DOLPP1 | BIN3 | 0.649287 | 4 | 0 | 3 |
| DOLPP1 | CNOT11 | 0.64516 | 4 | 0 | 4 |
| DOLPP1 | EXOSC5 | 0.644893 | 5 | 0 | 4 |
| DOLPP1 | EZH2 | 0.637602 | 5 | 0 | 5 |
| DOLPP1 | ASL | 0.637523 | 4 | 0 | 3 |
| DOLPP1 | GALE | 0.636053 | 5 | 0 | 3 |
| DOLPP1 | E2F8 | 0.634715 | 5 | 0 | 4 |
| DOLPP1 | PNPO | 0.63394 | 5 | 0 | 3 |
| DOLPP1 | P4HB | 0.633454 | 5 | 0 | 4 |
| DOLPP1 | BAIAP2L1 | 0.633295 | 5 | 0 | 3 |
| DOLPP1 | DKK1 | 0.631453 | 4 | 0 | 3 |
| DOLPP1 | MARVELD2 | 0.630004 | 5 | 0 | 3 |
For details and further investigation, click here
