| Full name: dickkopf WNT signaling pathway inhibitor 1 | Alias Symbol: SK|DKK-1 | ||
| Type: protein-coding gene | Cytoband: 10q21.1 | ||
| Entrez ID: 22943 | HGNC ID: HGNC:2891 | Ensembl Gene: ENSG00000107984 | OMIM ID: 605189 |
| Drug and gene relationship at DGIdb | |||
DKK1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway |
Expression of DKK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DKK1 | 22943 | 204602_at | 1.1709 | 0.6087 | |
| GSE20347 | DKK1 | 22943 | 204602_at | -0.8781 | 0.2719 | |
| GSE23400 | DKK1 | 22943 | 204602_at | -0.6338 | 0.0120 | |
| GSE26886 | DKK1 | 22943 | 204602_at | -1.3073 | 0.1728 | |
| GSE29001 | DKK1 | 22943 | 204602_at | -1.1107 | 0.1281 | |
| GSE38129 | DKK1 | 22943 | 204602_at | -0.1852 | 0.8173 | |
| GSE45670 | DKK1 | 22943 | 204602_at | 0.8101 | 0.3258 | |
| GSE53622 | DKK1 | 22943 | 97813 | -0.3512 | 0.3679 | |
| GSE53624 | DKK1 | 22943 | 97813 | -0.8619 | 0.0002 | |
| GSE63941 | DKK1 | 22943 | 204602_at | -0.4410 | 0.6967 | |
| GSE77861 | DKK1 | 22943 | 204602_at | -1.3348 | 0.1060 | |
| GSE97050 | DKK1 | 22943 | A_23_P24129 | 1.7804 | 0.1785 | |
| SRP007169 | DKK1 | 22943 | RNAseq | -0.9592 | 0.1268 | |
| SRP064894 | DKK1 | 22943 | RNAseq | -1.1874 | 0.0162 | |
| SRP133303 | DKK1 | 22943 | RNAseq | 0.1568 | 0.7715 | |
| SRP219564 | DKK1 | 22943 | RNAseq | 1.2214 | 0.1592 | |
| TCGA | DKK1 | 22943 | RNAseq | 0.8248 | 0.0024 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DKK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DKK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DKK1 | 22943 | 3 | 5 | 22 | |
| GSE20123 | DKK1 | 22943 | 4 | 5 | 21 | |
| GSE43470 | DKK1 | 22943 | 2 | 4 | 37 | |
| GSE46452 | DKK1 | 22943 | 0 | 13 | 46 | |
| GSE47630 | DKK1 | 22943 | 4 | 12 | 24 | |
| GSE54993 | DKK1 | 22943 | 9 | 0 | 61 | |
| GSE54994 | DKK1 | 22943 | 2 | 10 | 41 | |
| GSE60625 | DKK1 | 22943 | 0 | 0 | 11 | |
| GSE74703 | DKK1 | 22943 | 2 | 2 | 32 | |
| GSE74704 | DKK1 | 22943 | 1 | 4 | 15 | |
| TCGA | DKK1 | 22943 | 12 | 22 | 62 |
Total number of gains: 39; Total number of losses: 77; Total Number of normals: 372.
Somatic mutations of DKK1:
Generating mutation plots.
Highly correlated genes for DKK1:
Showing top 20/77 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DKK1 | LETM2 | 0.668596 | 3 | 0 | 3 |
| DKK1 | ALG6 | 0.650472 | 3 | 0 | 3 |
| DKK1 | SLC25A40 | 0.646518 | 3 | 0 | 3 |
| DKK1 | AP1S3 | 0.646032 | 5 | 0 | 4 |
| DKK1 | RAD18 | 0.645947 | 3 | 0 | 3 |
| DKK1 | RTKN2 | 0.6447 | 3 | 0 | 3 |
| DKK1 | SLC25A10 | 0.637583 | 3 | 0 | 3 |
| DKK1 | KIAA1522 | 0.634181 | 3 | 0 | 3 |
| DKK1 | DOLPP1 | 0.631453 | 4 | 0 | 3 |
| DKK1 | PPP3CC | 0.630781 | 3 | 0 | 3 |
| DKK1 | E2F2 | 0.623628 | 4 | 0 | 3 |
| DKK1 | ATP11B | 0.6231 | 3 | 0 | 3 |
| DKK1 | CTNNB1 | 0.606273 | 4 | 0 | 3 |
| DKK1 | MACC1 | 0.597946 | 4 | 0 | 3 |
| DKK1 | ZNF436 | 0.597001 | 4 | 0 | 3 |
| DKK1 | IL1RAP | 0.592979 | 5 | 0 | 3 |
| DKK1 | PPP1CA | 0.590928 | 6 | 0 | 3 |
| DKK1 | KLHL12 | 0.589148 | 6 | 0 | 4 |
| DKK1 | BCAR3 | 0.581608 | 6 | 0 | 3 |
| DKK1 | PFKFB3 | 0.577077 | 4 | 0 | 3 |
For details and further investigation, click here
