| Full name: bridging integrator 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8p21.3 | ||
| Entrez ID: 55909 | HGNC ID: HGNC:1054 | Ensembl Gene: ENSG00000147439 | OMIM ID: 606396 |
| Drug and gene relationship at DGIdb | |||
Expression of BIN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BIN3 | 55909 | 222199_s_at | 0.2114 | 0.5435 | |
| GSE20347 | BIN3 | 55909 | 222199_s_at | 0.1821 | 0.2283 | |
| GSE23400 | BIN3 | 55909 | 222199_s_at | -0.0345 | 0.6155 | |
| GSE26886 | BIN3 | 55909 | 222199_s_at | 0.2985 | 0.1069 | |
| GSE29001 | BIN3 | 55909 | 222199_s_at | -0.1843 | 0.5612 | |
| GSE38129 | BIN3 | 55909 | 222199_s_at | 0.1584 | 0.1860 | |
| GSE45670 | BIN3 | 55909 | 222199_s_at | 0.1085 | 0.3956 | |
| GSE63941 | BIN3 | 55909 | 222199_s_at | 0.0016 | 0.9973 | |
| GSE77861 | BIN3 | 55909 | 222199_s_at | 0.1722 | 0.5551 | |
| GSE97050 | BIN3 | 55909 | A_23_P43086 | 0.1416 | 0.6159 | |
| SRP007169 | BIN3 | 55909 | RNAseq | -0.9644 | 0.0294 | |
| SRP008496 | BIN3 | 55909 | RNAseq | -0.9596 | 0.0018 | |
| SRP064894 | BIN3 | 55909 | RNAseq | -0.2945 | 0.1445 | |
| SRP133303 | BIN3 | 55909 | RNAseq | -0.3080 | 0.1223 | |
| SRP159526 | BIN3 | 55909 | RNAseq | -0.4842 | 0.0917 | |
| SRP193095 | BIN3 | 55909 | RNAseq | -0.2923 | 0.0562 | |
| SRP219564 | BIN3 | 55909 | RNAseq | -0.0949 | 0.7559 | |
| TCGA | BIN3 | 55909 | RNAseq | -0.1263 | 0.0511 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by BIN3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of BIN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BIN3 | 55909 | 4 | 10 | 16 | |
| GSE20123 | BIN3 | 55909 | 4 | 10 | 16 | |
| GSE43470 | BIN3 | 55909 | 4 | 9 | 30 | |
| GSE46452 | BIN3 | 55909 | 13 | 13 | 33 | |
| GSE47630 | BIN3 | 55909 | 10 | 8 | 22 | |
| GSE54993 | BIN3 | 55909 | 2 | 14 | 54 | |
| GSE54994 | BIN3 | 55909 | 10 | 17 | 26 | |
| GSE60625 | BIN3 | 55909 | 3 | 0 | 8 | |
| GSE74703 | BIN3 | 55909 | 4 | 7 | 25 | |
| GSE74704 | BIN3 | 55909 | 3 | 7 | 10 | |
| TCGA | BIN3 | 55909 | 14 | 43 | 39 |
Total number of gains: 71; Total number of losses: 138; Total Number of normals: 279.
Somatic mutations of BIN3:
Generating mutation plots.
Highly correlated genes for BIN3:
Showing top 20/96 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BIN3 | RCE1 | 0.699178 | 3 | 0 | 3 |
| BIN3 | MED16 | 0.695984 | 3 | 0 | 3 |
| BIN3 | SQLE | 0.690531 | 3 | 0 | 3 |
| BIN3 | NUP188 | 0.672854 | 3 | 0 | 3 |
| BIN3 | TPM3 | 0.667768 | 3 | 0 | 3 |
| BIN3 | BCR | 0.660197 | 4 | 0 | 3 |
| BIN3 | EME1 | 0.658294 | 4 | 0 | 3 |
| BIN3 | RRBP1 | 0.656065 | 3 | 0 | 3 |
| BIN3 | EIF4EBP1 | 0.649709 | 6 | 0 | 4 |
| BIN3 | DOLPP1 | 0.649287 | 4 | 0 | 3 |
| BIN3 | FAM83H | 0.649063 | 4 | 0 | 3 |
| BIN3 | NMRAL1 | 0.64787 | 4 | 0 | 3 |
| BIN3 | TNKS1BP1 | 0.643384 | 3 | 0 | 3 |
| BIN3 | P4HB | 0.637364 | 4 | 0 | 3 |
| BIN3 | AP1S3 | 0.632961 | 3 | 0 | 3 |
| BIN3 | PPP4C | 0.62915 | 4 | 0 | 3 |
| BIN3 | UHRF1 | 0.623875 | 3 | 0 | 3 |
| BIN3 | NARF | 0.619051 | 3 | 0 | 3 |
| BIN3 | RALY-AS1 | 0.610415 | 3 | 0 | 3 |
| BIN3 | DSG2 | 0.604996 | 4 | 0 | 3 |
For details and further investigation, click here
