EZH2

 

Full name: enhancer of zeste 2 polycomb repressive complex 2 subunit Alias Symbol: EZH1|ENX-1|KMT6|KMT6A
Type: protein-coding gene Cytoband: 7q36.1
Entrez ID: 2146 HGNC ID: HGNC:3527 Ensembl Gene: ENSG00000106462 OMIM ID: 601573
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 19/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of EZH2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 EZH2 2146 203358_s_at 0.5389 0.4702
GSE20347 EZH2 2146 203358_s_at 1.0662 0.0000
GSE23400 EZH2 2146 203358_s_at 0.9823 0.0000
GSE26886 EZH2 2146 203358_s_at -0.9861 0.0026
GSE29001 EZH2 2146 203358_s_at 0.7910 0.0014
GSE38129 EZH2 2146 203358_s_at 1.5703 0.0000
GSE45670 EZH2 2146 203358_s_at 0.8579 0.0004
GSE53622 EZH2 2146 8860 0.4480 0.0040
GSE53624 EZH2 2146 8860 0.5860 0.0000
GSE63941 EZH2 2146 203358_s_at 2.4808 0.0001
GSE77861 EZH2 2146 203358_s_at 0.9516 0.0052
GSE97050 EZH2 2146 A_33_P3252196 0.6903 0.1156
SRP007169 EZH2 2146 RNAseq 0.7624 0.0481
SRP008496 EZH2 2146 RNAseq 0.4335 0.1723
SRP064894 EZH2 2146 RNAseq 0.8028 0.0048
SRP133303 EZH2 2146 RNAseq 0.7418 0.0131
SRP159526 EZH2 2146 RNAseq 0.7325 0.0007
SRP193095 EZH2 2146 RNAseq 0.2425 0.1456
SRP219564 EZH2 2146 RNAseq 0.1724 0.8013
TCGA EZH2 2146 RNAseq 0.7156 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by EZH2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EZH2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EZH2 2146 2 3 25
GSE20123 EZH2 2146 2 3 25
GSE43470 EZH2 2146 2 5 36
GSE46452 EZH2 2146 7 2 50
GSE47630 EZH2 2146 6 8 26
GSE54993 EZH2 2146 3 3 64
GSE54994 EZH2 2146 5 9 39
GSE60625 EZH2 2146 0 0 11
GSE74703 EZH2 2146 2 4 30
GSE74704 EZH2 2146 1 3 16
TCGA EZH2 2146 25 27 44

Total number of gains: 55; Total number of losses: 67; Total Number of normals: 366.  

 

Somatic mutations of EZH2:

 

Generating mutation plots.

 

Highly correlated genes for EZH2:

 

Showing top 20/1003 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EZH2THAP50.822069303
EZH2TFIP110.78921303
EZH2ANKIB10.788864303
EZH2SMCR80.782901303
EZH2XPNPEP30.770724403
EZH2LSM40.762973808
EZH2RACGAP10.756802909
EZH2HPS30.751384404
EZH2SS180.746621303
EZH2RPS6KA30.744702404
EZH2NUSAP10.73545911010
EZH2NUDCD10.732867303
EZH2LRRC580.732201404
EZH2CCDC1170.729311404
EZH2BROX0.727575303
EZH2COMMD20.727163505
EZH2KIF110.72427410010
EZH2ZNF1650.723778303
EZH2ZNF3170.722517404
EZH2CEP550.71677310010

For details and further investigation, click here