Full name: argininosuccinate lyase	Alias Symbol:
Type: protein-coding gene	Cytoband: 7q11.21
Entrez ID: 435	HGNC ID: HGNC:746	Ensembl Gene: ENSG00000126522	OMIM ID: 608310
Drug and gene relationship at DGIdb

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Expression of ASL:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	ASL	435	204608_at	-0.3043	0.7034	Show
GSE20347	ASL	435	204608_at	-1.0018	0.0000	Show
GSE23400	ASL	435	204608_at	-0.5155	0.0000	Show
GSE26886	ASL	435	204608_at	-0.7746	0.0000	Show
GSE29001	ASL	435	204608_at	-0.9301	0.0004	Show
GSE38129	ASL	435	204608_at	-0.7095	0.0004	Show
GSE45670	ASL	435	204608_at	-0.3712	0.0642	Show
GSE63941	ASL	435	204608_at	-0.7901	0.3091	Show
GSE77861	ASL	435	204608_at	-0.5656	0.1177	Show
GSE97050	ASL	435	A_23_P26223	0.5293	0.1740	Show
SRP007169	ASL	435	RNAseq	-2.0029	0.0000	Show
SRP008496	ASL	435	RNAseq	-1.8716	0.0000	Show
SRP064894	ASL	435	RNAseq	0.0967	0.6854	Show
SRP133303	ASL	435	RNAseq	-0.6273	0.0000	Show
SRP159526	ASL	435	RNAseq	-0.9050	0.0007	Show
SRP193095	ASL	435	RNAseq	-0.4782	0.0361	Show
SRP219564	ASL	435	RNAseq	-0.4221	0.2199	Show
TCGA	ASL	435	RNAseq	-0.4212	0.0000	Show

Upregulated datasets: 0; Downregulated datasets: 3.  Download Data

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Survival by ASL expression:

 

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Copy number change of ASL:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	ASL	435	11	2	17	Show
GSE20123	ASL	435	10	2	18	Show
GSE43470	ASL	435	2	1	40	Show
GSE46452	ASL	435	13	0	46	Show
GSE47630	ASL	435	7	1	32	Show
GSE54993	ASL	435	2	7	61	Show
GSE54994	ASL	435	12	4	37	Show
GSE60625	ASL	435	0	0	11	Show
GSE74703	ASL	435	2	1	33	Show
GSE74704	ASL	435	5	1	14	Show
TCGA	ASL	435	45	7	44	Show

Total number of gains: 109; Total number of losses: 26; Total Number of normals: 353.  Download Data

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Somatic mutations of ASL:

 

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Highly correlated genes for ASL:

 

Showing top 20/956 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
ASL	S100A16	0.755224	4	0	4
ASL	WDFY1	0.74053	4	0	4
ASL	TMEM79	0.737792	3	0	3
ASL	CARHSP1	0.725346	9	0	9
ASL	ZNF543	0.710009	3	0	3
ASL	C4orf33	0.707412	3	0	3
ASL	CPOX	0.704414	3	0	3
ASL	ORMDL2	0.703711	9	0	9
ASL	RABGGTA	0.702918	8	0	8
ASL	ST6GALNAC1	0.702804	4	0	4
ASL	MFSD5	0.700951	9	0	9
ASL	FAM160A1	0.699521	5	0	4
ASL	EVPL	0.696482	8	0	8
ASL	GRHL3	0.696334	4	0	4
ASL	TMEM154	0.69282	4	0	4
ASL	ZFAND2B	0.69239	5	0	4
ASL	ARPC2	0.691848	8	0	7
ASL	VPS25	0.691627	4	0	4
ASL	TIGD3	0.688058	3	0	3
ASL	CCDC85C	0.685561	3	0	3

For details and further investigation, click here