| Full name: exosome component 5 | Alias Symbol: hRrp46p|Rrp46p|RRP46|RRP41B|MGC12901|p12B | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 56915 | HGNC ID: HGNC:24662 | Ensembl Gene: ENSG00000077348 | OMIM ID: 606492 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EXOSC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EXOSC5 | 56915 | 218481_at | 0.4131 | 0.2575 | |
| GSE20347 | EXOSC5 | 56915 | 218481_at | 0.3015 | 0.0297 | |
| GSE23400 | EXOSC5 | 56915 | 218481_at | 0.2090 | 0.0023 | |
| GSE26886 | EXOSC5 | 56915 | 218481_at | 0.0449 | 0.8778 | |
| GSE29001 | EXOSC5 | 56915 | 218481_at | 0.3873 | 0.1598 | |
| GSE38129 | EXOSC5 | 56915 | 218481_at | 0.4785 | 0.0000 | |
| GSE45670 | EXOSC5 | 56915 | 218481_at | 0.1788 | 0.1975 | |
| GSE53622 | EXOSC5 | 56915 | 65496 | 0.2237 | 0.0221 | |
| GSE53624 | EXOSC5 | 56915 | 65496 | 0.4518 | 0.0000 | |
| GSE63941 | EXOSC5 | 56915 | 218481_at | 1.9087 | 0.0005 | |
| GSE77861 | EXOSC5 | 56915 | 218481_at | 0.0910 | 0.7006 | |
| GSE97050 | EXOSC5 | 56915 | A_24_P211151 | 0.4235 | 0.2110 | |
| SRP007169 | EXOSC5 | 56915 | RNAseq | -0.1585 | 0.7034 | |
| SRP008496 | EXOSC5 | 56915 | RNAseq | -0.3564 | 0.1476 | |
| SRP064894 | EXOSC5 | 56915 | RNAseq | 0.9394 | 0.0114 | |
| SRP133303 | EXOSC5 | 56915 | RNAseq | 0.4066 | 0.1478 | |
| SRP159526 | EXOSC5 | 56915 | RNAseq | 0.6365 | 0.0021 | |
| SRP193095 | EXOSC5 | 56915 | RNAseq | 0.2140 | 0.1142 | |
| SRP219564 | EXOSC5 | 56915 | RNAseq | 0.4008 | 0.3967 | |
| TCGA | EXOSC5 | 56915 | RNAseq | 0.4205 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by EXOSC5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EXOSC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EXOSC5 | 56915 | 4 | 4 | 22 | |
| GSE20123 | EXOSC5 | 56915 | 4 | 3 | 23 | |
| GSE43470 | EXOSC5 | 56915 | 3 | 11 | 29 | |
| GSE46452 | EXOSC5 | 56915 | 48 | 1 | 10 | |
| GSE47630 | EXOSC5 | 56915 | 9 | 5 | 26 | |
| GSE54993 | EXOSC5 | 56915 | 17 | 4 | 49 | |
| GSE54994 | EXOSC5 | 56915 | 7 | 11 | 35 | |
| GSE60625 | EXOSC5 | 56915 | 9 | 0 | 2 | |
| GSE74703 | EXOSC5 | 56915 | 3 | 7 | 26 | |
| GSE74704 | EXOSC5 | 56915 | 4 | 1 | 15 | |
| TCGA | EXOSC5 | 56915 | 14 | 16 | 66 |
Total number of gains: 122; Total number of losses: 63; Total Number of normals: 303.
Somatic mutations of EXOSC5:
Generating mutation plots.
Highly correlated genes for EXOSC5:
Showing top 20/864 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EXOSC5 | INO80B | 0.824203 | 3 | 0 | 3 |
| EXOSC5 | C10orf55 | 0.711537 | 3 | 0 | 3 |
| EXOSC5 | TTC38 | 0.69617 | 4 | 0 | 4 |
| EXOSC5 | PACS1 | 0.695183 | 3 | 0 | 3 |
| EXOSC5 | C12orf45 | 0.693184 | 5 | 0 | 5 |
| EXOSC5 | NUP133 | 0.683208 | 5 | 0 | 5 |
| EXOSC5 | GGN | 0.681932 | 3 | 0 | 3 |
| EXOSC5 | PI4KB | 0.675895 | 3 | 0 | 3 |
| EXOSC5 | LSM7 | 0.674432 | 10 | 0 | 9 |
| EXOSC5 | ZNF324B | 0.668607 | 4 | 0 | 3 |
| EXOSC5 | GUSB | 0.6678 | 3 | 0 | 3 |
| EXOSC5 | TSPAN33 | 0.666123 | 3 | 0 | 3 |
| EXOSC5 | SNRPD2 | 0.662852 | 11 | 0 | 9 |
| EXOSC5 | HSPB11 | 0.657126 | 5 | 0 | 5 |
| EXOSC5 | PSMB8 | 0.657122 | 6 | 0 | 6 |
| EXOSC5 | GTPBP3 | 0.656353 | 4 | 0 | 3 |
| EXOSC5 | PIK3R3 | 0.65287 | 3 | 0 | 3 |
| EXOSC5 | ZNF628 | 0.649928 | 5 | 0 | 5 |
| EXOSC5 | HM13 | 0.649503 | 4 | 0 | 3 |
| EXOSC5 | DLL4 | 0.645407 | 3 | 0 | 3 |
For details and further investigation, click here
