| Full name: dopamine receptor D3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q13.31 | ||
| Entrez ID: 1814 | HGNC ID: HGNC:3024 | Ensembl Gene: ENSG00000151577 | OMIM ID: 126451 |
| Drug and gene relationship at DGIdb | |||
DRD3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04728 | Dopaminergic synapse |
Expression of DRD3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DRD3 | 1814 | 214559_at | -0.2165 | 0.2432 | |
| GSE20347 | DRD3 | 1814 | 211625_s_at | 0.0060 | 0.9412 | |
| GSE23400 | DRD3 | 1814 | 211625_s_at | -0.0767 | 0.0045 | |
| GSE26886 | DRD3 | 1814 | 211625_s_at | 0.0224 | 0.8287 | |
| GSE29001 | DRD3 | 1814 | 211625_s_at | -0.0341 | 0.7639 | |
| GSE38129 | DRD3 | 1814 | 211625_s_at | -0.0395 | 0.4987 | |
| GSE45670 | DRD3 | 1814 | 214559_at | -0.1014 | 0.2089 | |
| GSE53622 | DRD3 | 1814 | 90707 | 0.1051 | 0.1598 | |
| GSE53624 | DRD3 | 1814 | 90707 | 0.0156 | 0.9076 | |
| GSE63941 | DRD3 | 1814 | 211625_s_at | 0.1031 | 0.5454 | |
| GSE77861 | DRD3 | 1814 | 211625_s_at | -0.1240 | 0.4075 | |
| GSE97050 | DRD3 | 1814 | A_23_P57733 | 0.0351 | 0.9114 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DRD3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DRD3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DRD3 | 1814 | 16 | 1 | 13 | |
| GSE20123 | DRD3 | 1814 | 16 | 2 | 12 | |
| GSE43470 | DRD3 | 1814 | 21 | 1 | 21 | |
| GSE46452 | DRD3 | 1814 | 13 | 5 | 41 | |
| GSE47630 | DRD3 | 1814 | 16 | 6 | 18 | |
| GSE54993 | DRD3 | 1814 | 2 | 6 | 62 | |
| GSE54994 | DRD3 | 1814 | 29 | 4 | 20 | |
| GSE60625 | DRD3 | 1814 | 0 | 6 | 5 | |
| GSE74703 | DRD3 | 1814 | 17 | 1 | 18 | |
| GSE74704 | DRD3 | 1814 | 12 | 2 | 6 | |
| TCGA | DRD3 | 1814 | 52 | 7 | 37 |
Total number of gains: 194; Total number of losses: 41; Total Number of normals: 253.
Somatic mutations of DRD3:
Generating mutation plots.
Highly correlated genes for DRD3:
Showing top 20/575 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DRD3 | PLA2G2C | 0.812605 | 3 | 0 | 3 |
| DRD3 | C1QL2 | 0.789553 | 3 | 0 | 3 |
| DRD3 | PRSS38 | 0.785486 | 3 | 0 | 3 |
| DRD3 | PABPN1L | 0.777308 | 3 | 0 | 3 |
| DRD3 | DCDC1 | 0.775816 | 3 | 0 | 3 |
| DRD3 | STRC | 0.770189 | 3 | 0 | 3 |
| DRD3 | OR2A5 | 0.757971 | 3 | 0 | 3 |
| DRD3 | FOXA3 | 0.756201 | 3 | 0 | 3 |
| DRD3 | OR2T27 | 0.75597 | 3 | 0 | 3 |
| DRD3 | YY2 | 0.753928 | 3 | 0 | 3 |
| DRD3 | SERTM1 | 0.727949 | 3 | 0 | 3 |
| DRD3 | GRXCR2 | 0.725344 | 3 | 0 | 3 |
| DRD3 | ABLIM3 | 0.720571 | 4 | 0 | 4 |
| DRD3 | BSX | 0.719626 | 3 | 0 | 3 |
| DRD3 | C9orf153 | 0.718271 | 3 | 0 | 3 |
| DRD3 | DEGS2 | 0.709771 | 4 | 0 | 4 |
| DRD3 | MRGPRG | 0.707939 | 3 | 0 | 3 |
| DRD3 | DEFB121 | 0.707291 | 4 | 0 | 3 |
| DRD3 | C14orf180 | 0.70702 | 3 | 0 | 3 |
| DRD3 | KCTD19 | 0.704309 | 3 | 0 | 3 |
For details and further investigation, click here
