SHC1

 

Full name: SHC adaptor protein 1 Alias Symbol: p66|ShcA
Type: protein-coding gene Cytoband: 1q21.3
Entrez ID: 6464 HGNC ID: HGNC:10840 Ensembl Gene: ENSG00000160691 OMIM ID: 600560
Drug and gene relationship at DGIdb
Screen Evidence:

 

SHC1 involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04510Focal adhesion
hsa04650Natural killer cell mediated cytotoxicity
hsa04722Neurotrophin signaling pathway
hsa04910Insulin signaling pathway
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa05214Glioma
hsa05220Chronic myeloid leukemia

 

Expression of SHC1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SHC1 6464 214853_s_at 0.9777 0.0262
GSE20347 SHC1 6464 214853_s_at 0.7288 0.0000
GSE23400 SHC1 6464 214853_s_at 0.8063 0.0000
GSE26886 SHC1 6464 214853_s_at 0.6312 0.0051
GSE29001 SHC1 6464 214853_s_at 0.5988 0.0438
GSE38129 SHC1 6464 214853_s_at 0.7252 0.0000
GSE45670 SHC1 6464 214853_s_at 0.4971 0.0232
GSE53622 SHC1 6464 34147 0.8310 0.0000
GSE53624 SHC1 6464 34147 0.9361 0.0000
GSE63941 SHC1 6464 214853_s_at -1.3872 0.0240
GSE77861 SHC1 6464 214853_s_at 1.1333 0.0055
GSE97050 SHC1 6464 A_24_P68585 0.5750 0.1065
SRP007169 SHC1 6464 RNAseq 0.3128 0.3110
SRP008496 SHC1 6464 RNAseq 0.4468 0.0090
SRP064894 SHC1 6464 RNAseq 0.9573 0.0000
SRP133303 SHC1 6464 RNAseq 1.0220 0.0001
SRP159526 SHC1 6464 RNAseq 0.9879 0.0130
SRP193095 SHC1 6464 RNAseq 1.1332 0.0000
SRP219564 SHC1 6464 RNAseq 1.0037 0.0094
TCGA SHC1 6464 RNAseq 0.1242 0.0181

Upregulated datasets: 4; Downregulated datasets: 1.  

 

Survival by SHC1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SHC1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SHC1 6464 14 0 16
GSE20123 SHC1 6464 13 0 17
GSE43470 SHC1 6464 6 2 35
GSE46452 SHC1 6464 2 1 56
GSE47630 SHC1 6464 14 0 26
GSE54993 SHC1 6464 0 4 66
GSE54994 SHC1 6464 16 0 37
GSE60625 SHC1 6464 0 0 11
GSE74703 SHC1 6464 6 1 29
GSE74704 SHC1 6464 6 0 14
TCGA SHC1 6464 38 2 56

Total number of gains: 115; Total number of losses: 10; Total Number of normals: 363.  

 

Somatic mutations of SHC1:

 

Generating mutation plots.

 

Highly correlated genes for SHC1:

 

Showing top 20/1544 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SHC1FAM89A0.839467303
SHC1CASC40.78588303
SHC1SPON20.778192303
SHC1FMNL20.772148707
SHC1LETM20.77204303
SHC1CDCA20.764953403
SHC1KIAA09300.76356310010
SHC1UTP230.762843404
SHC1PLAU0.76220211011
SHC1CD99L20.761387303
SHC1XPR10.761343707
SHC1YWHAG0.741825505
SHC1GTF3C20.74074303
SHC1WDR540.740338706
SHC1PFDN20.73948611011
SHC1DSTYK0.739277303
SHC1ARPC1B0.73833612011
SHC1ZNF4690.733831707
SHC1FIP1L10.732643303
SHC1SLC35B20.729552303

For details and further investigation, click here