| Full name: ral guanine nucleotide dissociation stimulator like 1 | Alias Symbol: RGL | ||
| Type: protein-coding gene | Cytoband: 1q25.3 | ||
| Entrez ID: 23179 | HGNC ID: HGNC:30281 | Ensembl Gene: ENSG00000143344 | OMIM ID: 605667 |
| Drug and gene relationship at DGIdb | |||
RGL1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway |
Expression of RGL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RGL1 | 23179 | 209568_s_at | -0.0240 | 0.9739 | |
| GSE20347 | RGL1 | 23179 | 209568_s_at | 0.3744 | 0.0605 | |
| GSE23400 | RGL1 | 23179 | 209568_s_at | -0.0986 | 0.3394 | |
| GSE26886 | RGL1 | 23179 | 209568_s_at | 0.7352 | 0.0139 | |
| GSE29001 | RGL1 | 23179 | 209568_s_at | 0.3144 | 0.3904 | |
| GSE38129 | RGL1 | 23179 | 209568_s_at | -0.1093 | 0.6723 | |
| GSE45670 | RGL1 | 23179 | 209568_s_at | -0.6964 | 0.0099 | |
| GSE53622 | RGL1 | 23179 | 47378 | -0.2671 | 0.0066 | |
| GSE53624 | RGL1 | 23179 | 47378 | -0.0279 | 0.7866 | |
| GSE63941 | RGL1 | 23179 | 209568_s_at | -3.8836 | 0.0000 | |
| GSE77861 | RGL1 | 23179 | 209568_s_at | 0.5596 | 0.0072 | |
| GSE97050 | RGL1 | 23179 | A_33_P3240532 | -0.3982 | 0.3724 | |
| SRP007169 | RGL1 | 23179 | RNAseq | 0.5369 | 0.1788 | |
| SRP008496 | RGL1 | 23179 | RNAseq | 0.8239 | 0.0089 | |
| SRP064894 | RGL1 | 23179 | RNAseq | 0.1144 | 0.7179 | |
| SRP133303 | RGL1 | 23179 | RNAseq | -0.4025 | 0.1572 | |
| SRP159526 | RGL1 | 23179 | RNAseq | 0.2638 | 0.4379 | |
| SRP193095 | RGL1 | 23179 | RNAseq | 0.3677 | 0.0131 | |
| SRP219564 | RGL1 | 23179 | RNAseq | 0.4280 | 0.6071 | |
| TCGA | RGL1 | 23179 | RNAseq | -0.0950 | 0.2987 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by RGL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RGL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RGL1 | 23179 | 12 | 0 | 18 | |
| GSE20123 | RGL1 | 23179 | 12 | 0 | 18 | |
| GSE43470 | RGL1 | 23179 | 7 | 1 | 35 | |
| GSE46452 | RGL1 | 23179 | 3 | 1 | 55 | |
| GSE47630 | RGL1 | 23179 | 14 | 0 | 26 | |
| GSE54993 | RGL1 | 23179 | 0 | 6 | 64 | |
| GSE54994 | RGL1 | 23179 | 15 | 0 | 38 | |
| GSE60625 | RGL1 | 23179 | 0 | 0 | 11 | |
| GSE74703 | RGL1 | 23179 | 7 | 1 | 28 | |
| GSE74704 | RGL1 | 23179 | 5 | 0 | 15 | |
| TCGA | RGL1 | 23179 | 40 | 3 | 53 |
Total number of gains: 115; Total number of losses: 12; Total Number of normals: 361.
Somatic mutations of RGL1:
Generating mutation plots.
Highly correlated genes for RGL1:
Showing top 20/1093 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RGL1 | SEMA6A | 0.795525 | 3 | 0 | 3 |
| RGL1 | DPP4 | 0.788794 | 3 | 0 | 3 |
| RGL1 | WDR81 | 0.783936 | 3 | 0 | 3 |
| RGL1 | MED29 | 0.779324 | 3 | 0 | 3 |
| RGL1 | UXS1 | 0.777005 | 3 | 0 | 3 |
| RGL1 | IMPAD1 | 0.774345 | 3 | 0 | 3 |
| RGL1 | PLEKHM3 | 0.766574 | 3 | 0 | 3 |
| RGL1 | SYNC | 0.75981 | 4 | 0 | 4 |
| RGL1 | SLC4A4 | 0.75968 | 3 | 0 | 3 |
| RGL1 | KBTBD6 | 0.758579 | 3 | 0 | 3 |
| RGL1 | RILPL1 | 0.734316 | 3 | 0 | 3 |
| RGL1 | GPC6 | 0.731466 | 4 | 0 | 4 |
| RGL1 | SMAD7 | 0.729134 | 6 | 0 | 5 |
| RGL1 | HINT1 | 0.72796 | 3 | 0 | 3 |
| RGL1 | EIF2AK4 | 0.727222 | 3 | 0 | 3 |
| RGL1 | IQCE | 0.726102 | 4 | 0 | 4 |
| RGL1 | SLC12A4 | 0.716216 | 4 | 0 | 4 |
| RGL1 | STK3 | 0.714716 | 3 | 0 | 3 |
| RGL1 | ZNF202 | 0.713504 | 3 | 0 | 3 |
| RGL1 | HERC2 | 0.709591 | 4 | 0 | 3 |
For details and further investigation, click here
