| Full name: E4F transcription factor 1 | Alias Symbol: E4F | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 1877 | HGNC ID: HGNC:3121 | Ensembl Gene: ENSG00000167967 | OMIM ID: 603022 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of E4F1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | E4F1 | 1877 | 218524_at | 0.3320 | 0.2143 | |
| GSE20347 | E4F1 | 1877 | 218524_at | 0.3565 | 0.0014 | |
| GSE23400 | E4F1 | 1877 | 218524_at | 0.2027 | 0.0000 | |
| GSE26886 | E4F1 | 1877 | 218524_at | 0.7659 | 0.0001 | |
| GSE29001 | E4F1 | 1877 | 218524_at | 0.4694 | 0.0303 | |
| GSE38129 | E4F1 | 1877 | 218524_at | 0.2916 | 0.0003 | |
| GSE45670 | E4F1 | 1877 | 218524_at | 0.1245 | 0.2398 | |
| GSE53622 | E4F1 | 1877 | 2641 | 0.1481 | 0.1423 | |
| GSE53624 | E4F1 | 1877 | 2641 | 0.3676 | 0.0000 | |
| GSE63941 | E4F1 | 1877 | 218524_at | -0.3040 | 0.1650 | |
| GSE77861 | E4F1 | 1877 | 218524_at | 0.3933 | 0.0711 | |
| GSE97050 | E4F1 | 1877 | A_23_P15045 | 0.2001 | 0.4585 | |
| SRP007169 | E4F1 | 1877 | RNAseq | 0.7092 | 0.1720 | |
| SRP008496 | E4F1 | 1877 | RNAseq | 1.2532 | 0.0060 | |
| SRP064894 | E4F1 | 1877 | RNAseq | 0.2842 | 0.1767 | |
| SRP133303 | E4F1 | 1877 | RNAseq | 0.3640 | 0.0497 | |
| SRP159526 | E4F1 | 1877 | RNAseq | 0.3905 | 0.0317 | |
| SRP193095 | E4F1 | 1877 | RNAseq | 0.3304 | 0.0011 | |
| SRP219564 | E4F1 | 1877 | RNAseq | 0.2824 | 0.4087 | |
| TCGA | E4F1 | 1877 | RNAseq | 0.0594 | 0.2694 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by E4F1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of E4F1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | E4F1 | 1877 | 5 | 5 | 20 | |
| GSE20123 | E4F1 | 1877 | 5 | 4 | 21 | |
| GSE43470 | E4F1 | 1877 | 4 | 7 | 32 | |
| GSE46452 | E4F1 | 1877 | 38 | 1 | 20 | |
| GSE47630 | E4F1 | 1877 | 13 | 6 | 21 | |
| GSE54993 | E4F1 | 1877 | 3 | 5 | 62 | |
| GSE54994 | E4F1 | 1877 | 5 | 9 | 39 | |
| GSE60625 | E4F1 | 1877 | 4 | 0 | 7 | |
| GSE74703 | E4F1 | 1877 | 4 | 5 | 27 | |
| GSE74704 | E4F1 | 1877 | 3 | 2 | 15 | |
| TCGA | E4F1 | 1877 | 19 | 14 | 63 |
Total number of gains: 103; Total number of losses: 58; Total Number of normals: 327.
Somatic mutations of E4F1:
Generating mutation plots.
Highly correlated genes for E4F1:
Showing top 20/861 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| E4F1 | MCMBP | 0.811974 | 3 | 0 | 3 |
| E4F1 | LRRC58 | 0.781211 | 4 | 0 | 4 |
| E4F1 | ARL13B | 0.780302 | 3 | 0 | 3 |
| E4F1 | DVL1 | 0.767433 | 3 | 0 | 3 |
| E4F1 | NOC3L | 0.767365 | 3 | 0 | 3 |
| E4F1 | C7orf50 | 0.766243 | 3 | 0 | 3 |
| E4F1 | ZFYVE9 | 0.763547 | 3 | 0 | 3 |
| E4F1 | CCDC97 | 0.746719 | 3 | 0 | 3 |
| E4F1 | COMMD7 | 0.739613 | 3 | 0 | 3 |
| E4F1 | MAK16 | 0.734575 | 3 | 0 | 3 |
| E4F1 | GET4 | 0.732365 | 3 | 0 | 3 |
| E4F1 | PHC2 | 0.732292 | 3 | 0 | 3 |
| E4F1 | RPL7L1 | 0.72715 | 4 | 0 | 4 |
| E4F1 | ZNF623 | 0.72405 | 3 | 0 | 3 |
| E4F1 | DNAJC19 | 0.71905 | 3 | 0 | 3 |
| E4F1 | NOM1 | 0.714754 | 4 | 0 | 4 |
| E4F1 | ZNF766 | 0.713826 | 4 | 0 | 3 |
| E4F1 | ZNHIT2 | 0.712875 | 5 | 0 | 5 |
| E4F1 | MOB3C | 0.712145 | 4 | 0 | 4 |
| E4F1 | AURKAIP1 | 0.711011 | 5 | 0 | 3 |
For details and further investigation, click here
