| Full name: dishevelled segment polarity protein 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p36.33 | ||
| Entrez ID: 1855 | HGNC ID: HGNC:3084 | Ensembl Gene: ENSG00000107404 | OMIM ID: 601365 |
| Drug and gene relationship at DGIdb | |||
DVL1 involved pathways:
Expression of DVL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DVL1 | 1855 | 203230_at | 0.0701 | 0.9153 | |
| GSE20347 | DVL1 | 1855 | 203230_at | -0.3128 | 0.0327 | |
| GSE23400 | DVL1 | 1855 | 203230_at | -0.1458 | 0.0810 | |
| GSE26886 | DVL1 | 1855 | 203230_at | 0.4963 | 0.0167 | |
| GSE29001 | DVL1 | 1855 | 203230_at | -0.3058 | 0.1268 | |
| GSE38129 | DVL1 | 1855 | 203230_at | -0.2162 | 0.0502 | |
| GSE45670 | DVL1 | 1855 | 203230_at | -0.0714 | 0.6028 | |
| GSE53622 | DVL1 | 1855 | 60181 | -0.5257 | 0.0000 | |
| GSE53624 | DVL1 | 1855 | 60181 | -0.3066 | 0.0000 | |
| GSE63941 | DVL1 | 1855 | 203230_at | 0.2102 | 0.6483 | |
| GSE77861 | DVL1 | 1855 | 203230_at | -0.1634 | 0.5441 | |
| GSE97050 | DVL1 | 1855 | A_23_P201342 | -0.4347 | 0.2841 | |
| SRP007169 | DVL1 | 1855 | RNAseq | -1.7557 | 0.0002 | |
| SRP008496 | DVL1 | 1855 | RNAseq | -1.6134 | 0.0000 | |
| SRP064894 | DVL1 | 1855 | RNAseq | -0.1672 | 0.3822 | |
| SRP133303 | DVL1 | 1855 | RNAseq | -0.4193 | 0.0084 | |
| SRP159526 | DVL1 | 1855 | RNAseq | -0.4150 | 0.1602 | |
| SRP193095 | DVL1 | 1855 | RNAseq | -0.1205 | 0.3529 | |
| SRP219564 | DVL1 | 1855 | RNAseq | -0.4619 | 0.2073 | |
| TCGA | DVL1 | 1855 | RNAseq | -0.1062 | 0.0501 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by DVL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DVL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DVL1 | 1855 | 3 | 7 | 20 | |
| GSE20123 | DVL1 | 1855 | 3 | 6 | 21 | |
| GSE43470 | DVL1 | 1855 | 3 | 5 | 35 | |
| GSE46452 | DVL1 | 1855 | 7 | 1 | 51 | |
| GSE47630 | DVL1 | 1855 | 8 | 4 | 28 | |
| GSE54993 | DVL1 | 1855 | 2 | 2 | 66 | |
| GSE54994 | DVL1 | 1855 | 15 | 2 | 36 | |
| GSE60625 | DVL1 | 1855 | 0 | 0 | 11 | |
| GSE74703 | DVL1 | 1855 | 3 | 3 | 30 | |
| GSE74704 | DVL1 | 1855 | 3 | 0 | 17 | |
| TCGA | DVL1 | 1855 | 14 | 20 | 62 |
Total number of gains: 61; Total number of losses: 50; Total Number of normals: 377.
Somatic mutations of DVL1:
Generating mutation plots.
Highly correlated genes for DVL1:
Showing top 20/483 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DVL1 | CHCHD1 | 0.771596 | 3 | 0 | 3 |
| DVL1 | PDK2 | 0.770169 | 3 | 0 | 3 |
| DVL1 | ZNF683 | 0.768034 | 3 | 0 | 3 |
| DVL1 | E4F1 | 0.767433 | 3 | 0 | 3 |
| DVL1 | SNRPF | 0.764743 | 3 | 0 | 3 |
| DVL1 | C9orf16 | 0.760116 | 3 | 0 | 3 |
| DVL1 | LIN7B | 0.752921 | 3 | 0 | 3 |
| DVL1 | MRPS21 | 0.749762 | 3 | 0 | 3 |
| DVL1 | TRUB2 | 0.74363 | 3 | 0 | 3 |
| DVL1 | FN3K | 0.740842 | 3 | 0 | 3 |
| DVL1 | MTHFR | 0.740495 | 3 | 0 | 3 |
| DVL1 | DEF8 | 0.740385 | 3 | 0 | 3 |
| DVL1 | BSN | 0.735179 | 3 | 0 | 3 |
| DVL1 | SESN2 | 0.720284 | 3 | 0 | 3 |
| DVL1 | PPP1R15A | 0.717466 | 3 | 0 | 3 |
| DVL1 | ZNF555 | 0.715089 | 3 | 0 | 3 |
| DVL1 | CPT1A | 0.713131 | 3 | 0 | 3 |
| DVL1 | ADCK1 | 0.713125 | 3 | 0 | 3 |
| DVL1 | C11orf80 | 0.711974 | 3 | 0 | 3 |
| DVL1 | FXR2 | 0.710362 | 3 | 0 | 3 |
For details and further investigation, click here
