| Full name: polyhomeotic homolog 2 | Alias Symbol: HPH2 | ||
| Type: protein-coding gene | Cytoband: 1p35.1 | ||
| Entrez ID: 1912 | HGNC ID: HGNC:3183 | Ensembl Gene: ENSG00000134686 | OMIM ID: 602979 |
| Drug and gene relationship at DGIdb | |||
Expression of PHC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHC2 | 1912 | 200919_at | 0.1882 | 0.7012 | |
| GSE20347 | PHC2 | 1912 | 200919_at | 0.4414 | 0.0012 | |
| GSE23400 | PHC2 | 1912 | 200919_at | 0.2220 | 0.0000 | |
| GSE26886 | PHC2 | 1912 | 200919_at | 0.7819 | 0.0001 | |
| GSE29001 | PHC2 | 1912 | 200919_at | 0.4808 | 0.0037 | |
| GSE38129 | PHC2 | 1912 | 200919_at | 0.1653 | 0.3016 | |
| GSE45670 | PHC2 | 1912 | 200919_at | -0.1100 | 0.5956 | |
| GSE53622 | PHC2 | 1912 | 34723 | 0.2615 | 0.0042 | |
| GSE53624 | PHC2 | 1912 | 34723 | 0.5186 | 0.0000 | |
| GSE63941 | PHC2 | 1912 | 200919_at | -0.4935 | 0.1945 | |
| GSE77861 | PHC2 | 1912 | 200919_at | 0.3074 | 0.0992 | |
| GSE97050 | PHC2 | 1912 | A_23_P423864 | 0.1379 | 0.4868 | |
| SRP007169 | PHC2 | 1912 | RNAseq | 0.7484 | 0.0640 | |
| SRP008496 | PHC2 | 1912 | RNAseq | 0.7560 | 0.0115 | |
| SRP064894 | PHC2 | 1912 | RNAseq | 0.7548 | 0.0033 | |
| SRP133303 | PHC2 | 1912 | RNAseq | 0.5518 | 0.0231 | |
| SRP159526 | PHC2 | 1912 | RNAseq | 0.2702 | 0.3332 | |
| SRP193095 | PHC2 | 1912 | RNAseq | 0.5527 | 0.0003 | |
| SRP219564 | PHC2 | 1912 | RNAseq | 0.0714 | 0.8694 | |
| TCGA | PHC2 | 1912 | RNAseq | -0.1807 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PHC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PHC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHC2 | 1912 | 2 | 5 | 23 | |
| GSE20123 | PHC2 | 1912 | 2 | 4 | 24 | |
| GSE43470 | PHC2 | 1912 | 5 | 4 | 34 | |
| GSE46452 | PHC2 | 1912 | 4 | 1 | 54 | |
| GSE47630 | PHC2 | 1912 | 8 | 3 | 29 | |
| GSE54993 | PHC2 | 1912 | 1 | 1 | 68 | |
| GSE54994 | PHC2 | 1912 | 11 | 2 | 40 | |
| GSE60625 | PHC2 | 1912 | 0 | 0 | 11 | |
| GSE74703 | PHC2 | 1912 | 4 | 3 | 29 | |
| GSE74704 | PHC2 | 1912 | 1 | 0 | 19 | |
| TCGA | PHC2 | 1912 | 12 | 18 | 66 |
Total number of gains: 50; Total number of losses: 41; Total Number of normals: 397.
Somatic mutations of PHC2:
Generating mutation plots.
Highly correlated genes for PHC2:
Showing top 20/1518 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHC2 | LMO1 | 0.832567 | 3 | 0 | 3 |
| PHC2 | DNAJC11 | 0.806975 | 3 | 0 | 3 |
| PHC2 | GRWD1 | 0.774075 | 3 | 0 | 3 |
| PHC2 | UTP23 | 0.754698 | 3 | 0 | 3 |
| PHC2 | CD3EAP | 0.746396 | 4 | 0 | 4 |
| PHC2 | EFTUD2 | 0.74021 | 3 | 0 | 3 |
| PHC2 | ANAPC5 | 0.738118 | 3 | 0 | 3 |
| PHC2 | MOGS | 0.734406 | 4 | 0 | 4 |
| PHC2 | E4F1 | 0.732292 | 3 | 0 | 3 |
| PHC2 | ZNF771 | 0.730256 | 3 | 0 | 3 |
| PHC2 | ZNF691 | 0.726969 | 3 | 0 | 3 |
| PHC2 | PRKCSH | 0.726561 | 3 | 0 | 3 |
| PHC2 | ZC3H3 | 0.723283 | 3 | 0 | 3 |
| PHC2 | USP14 | 0.721619 | 4 | 0 | 4 |
| PHC2 | RILPL1 | 0.720759 | 4 | 0 | 3 |
| PHC2 | CEP250 | 0.720666 | 3 | 0 | 3 |
| PHC2 | FCGR3A | 0.719468 | 3 | 0 | 3 |
| PHC2 | RAVER1 | 0.717839 | 3 | 0 | 3 |
| PHC2 | RNF4 | 0.71671 | 3 | 0 | 3 |
| PHC2 | PAQR4 | 0.715358 | 4 | 0 | 4 |
For details and further investigation, click here
