ECE1

 

Full name: endothelin converting enzyme 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 1p36.12
Entrez ID: 1889 HGNC ID: HGNC:3146 Ensembl Gene: ENSG00000117298 OMIM ID: 600423
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ECE1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ECE1 1889 201749_at 0.9075 0.0416
GSE20347 ECE1 1889 201749_at 0.7891 0.0000
GSE23400 ECE1 1889 201749_at 0.4012 0.0000
GSE26886 ECE1 1889 201749_at 1.2575 0.0000
GSE29001 ECE1 1889 201749_at 0.5066 0.0195
GSE38129 ECE1 1889 201749_at 0.5963 0.0021
GSE45670 ECE1 1889 201749_at 0.3178 0.0416
GSE53622 ECE1 1889 161921 0.8522 0.0000
GSE53624 ECE1 1889 161921 0.9482 0.0000
GSE63941 ECE1 1889 201749_at -0.9322 0.0140
GSE77861 ECE1 1889 201749_at 0.5655 0.0331
GSE97050 ECE1 1889 A_24_P154080 1.0299 0.0872
SRP007169 ECE1 1889 RNAseq 2.3673 0.0000
SRP008496 ECE1 1889 RNAseq 2.3407 0.0000
SRP064894 ECE1 1889 RNAseq 1.2277 0.0000
SRP133303 ECE1 1889 RNAseq 0.7757 0.0015
SRP159526 ECE1 1889 RNAseq 1.5587 0.0000
SRP193095 ECE1 1889 RNAseq 1.6337 0.0000
SRP219564 ECE1 1889 RNAseq 0.6851 0.1715
TCGA ECE1 1889 RNAseq 0.0854 0.1572

Upregulated datasets: 6; Downregulated datasets: 0.  

 

Survival by ECE1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ECE1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ECE1 1889 0 5 25
GSE20123 ECE1 1889 0 4 26
GSE43470 ECE1 1889 2 6 35
GSE46452 ECE1 1889 5 1 53
GSE47630 ECE1 1889 8 3 29
GSE54993 ECE1 1889 3 1 66
GSE54994 ECE1 1889 11 4 38
GSE60625 ECE1 1889 0 0 11
GSE74703 ECE1 1889 1 4 31
GSE74704 ECE1 1889 0 0 20
TCGA ECE1 1889 9 23 64

Total number of gains: 39; Total number of losses: 51; Total Number of normals: 398.  

 

Somatic mutations of ECE1:

 

Generating mutation plots.

 

Highly correlated genes for ECE1:

 

Showing top 20/1478 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ECE1PYCR20.809583303
ECE1FADS10.760715303
ECE1SLC39A30.75231404
ECE1TMEM184B0.73040311010
ECE1PDIA50.729638303
ECE1SNAP470.720004303
ECE1CD2760.717685505
ECE1COMMD70.71317403
ECE1RAB340.712916303
ECE1INTS100.712112303
ECE1MAN1A10.710951504
ECE1HEY10.70874911011
ECE1PLXNA10.7063111010
ECE1RNF40.705865303
ECE1LRRC8C0.705485303
ECE1NAA380.704856403
ECE1DGKQ0.704233303
ECE1HMCN10.703063404
ECE1CLPTM1L0.702239707
ECE1SLC41A10.700297707

For details and further investigation, click here