MAN1A1

 

Full name: mannosidase alpha class 1A member 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 6q22.31
Entrez ID: 4121 HGNC ID: HGNC:6821 Ensembl Gene: ENSG00000111885 OMIM ID: 604344
Drug and gene relationship at DGIdb

 

Expression of MAN1A1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAN1A1 4121 221760_at -0.4116 0.6251
GSE20347 MAN1A1 4121 221760_at 0.5167 0.1686
GSE23400 MAN1A1 4121 221760_at 0.1682 0.4087
GSE26886 MAN1A1 4121 221760_at 2.1173 0.0005
GSE29001 MAN1A1 4121 221760_at 0.7284 0.1486
GSE38129 MAN1A1 4121 221760_at 0.0639 0.8759
GSE45670 MAN1A1 4121 221760_at -1.0344 0.0252
GSE53622 MAN1A1 4121 77002 0.0301 0.8651
GSE53624 MAN1A1 4121 77002 0.1615 0.4446
GSE63941 MAN1A1 4121 221760_at -5.6900 0.0002
GSE77861 MAN1A1 4121 221760_at 1.4017 0.1383
GSE97050 MAN1A1 4121 A_33_P3303414 0.1682 0.4802
SRP007169 MAN1A1 4121 RNAseq 1.5739 0.0026
SRP008496 MAN1A1 4121 RNAseq 2.1073 0.0000
SRP064894 MAN1A1 4121 RNAseq 0.4880 0.1987
SRP133303 MAN1A1 4121 RNAseq 0.1122 0.6750
SRP159526 MAN1A1 4121 RNAseq 0.1896 0.6885
SRP193095 MAN1A1 4121 RNAseq 0.3345 0.3312
SRP219564 MAN1A1 4121 RNAseq 0.5202 0.3971
TCGA MAN1A1 4121 RNAseq -0.2858 0.0145

Upregulated datasets: 3; Downregulated datasets: 2.  

 

Survival by MAN1A1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAN1A1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAN1A1 4121 1 4 25
GSE20123 MAN1A1 4121 1 3 26
GSE43470 MAN1A1 4121 4 2 37
GSE46452 MAN1A1 4121 2 11 46
GSE47630 MAN1A1 4121 9 4 27
GSE54993 MAN1A1 4121 3 2 65
GSE54994 MAN1A1 4121 8 8 37
GSE60625 MAN1A1 4121 0 1 10
GSE74703 MAN1A1 4121 3 2 31
GSE74704 MAN1A1 4121 0 1 19
TCGA MAN1A1 4121 10 19 67

Total number of gains: 41; Total number of losses: 57; Total Number of normals: 390.  

 

Somatic mutations of MAN1A1:

 

Generating mutation plots.

 

Highly correlated genes for MAN1A1:

 

Showing top 20/1218 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAN1A1VOPP10.815055303
MAN1A1DOCK110.772186606
MAN1A1COL12A10.750503505
MAN1A1TP53I130.748611303
MAN1A1PREX10.747504303
MAN1A1GNG20.73921605
MAN1A1GAA0.738907303
MAN1A1CLMP0.7369606
MAN1A1TRAF30.736498303
MAN1A1PTPN140.736466303
MAN1A1TNFRSF10D0.732446403
MAN1A1CCM20.73222303
MAN1A1GPR1410.731601303
MAN1A1RFTN10.7307713012
MAN1A1TMEM600.726618303
MAN1A1FHL30.725533303
MAN1A1VPS13C0.72552912011
MAN1A1MGAT50.724687403
MAN1A1WDR810.72426303
MAN1A1ZNF6550.721845303

For details and further investigation, click here