| Full name: CD276 molecule | Alias Symbol: B7-H3|B7H3|B7RP-2 | ||
| Type: protein-coding gene | Cytoband: 15q24.1 | ||
| Entrez ID: 80381 | HGNC ID: HGNC:19137 | Ensembl Gene: ENSG00000103855 | OMIM ID: 605715 |
| Drug and gene relationship at DGIdb | |||
Expression of CD276:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD276 | 80381 | 224859_at | 1.2795 | 0.0138 | |
| GSE26886 | CD276 | 80381 | 224859_at | 1.1620 | 0.0000 | |
| GSE45670 | CD276 | 80381 | 224859_at | 0.8661 | 0.0021 | |
| GSE53622 | CD276 | 80381 | 53899 | -0.0089 | 0.9189 | |
| GSE53624 | CD276 | 80381 | 53899 | -0.2109 | 0.0024 | |
| GSE63941 | CD276 | 80381 | 224859_at | -0.7611 | 0.1032 | |
| GSE77861 | CD276 | 80381 | 224859_at | 1.0006 | 0.0008 | |
| GSE97050 | CD276 | 80381 | A_33_P3217393 | 0.4699 | 0.1973 | |
| SRP007169 | CD276 | 80381 | RNAseq | 2.9672 | 0.0000 | |
| SRP008496 | CD276 | 80381 | RNAseq | 3.3898 | 0.0000 | |
| SRP064894 | CD276 | 80381 | RNAseq | 2.3597 | 0.0000 | |
| SRP133303 | CD276 | 80381 | RNAseq | 2.3848 | 0.0000 | |
| SRP159526 | CD276 | 80381 | RNAseq | 2.4646 | 0.0000 | |
| SRP193095 | CD276 | 80381 | RNAseq | 2.6105 | 0.0000 | |
| SRP219564 | CD276 | 80381 | RNAseq | 2.0198 | 0.0007 | |
| TCGA | CD276 | 80381 | RNAseq | 0.3368 | 0.0000 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by CD276 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD276:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD276 | 80381 | 8 | 0 | 22 | |
| GSE20123 | CD276 | 80381 | 8 | 0 | 22 | |
| GSE43470 | CD276 | 80381 | 4 | 6 | 33 | |
| GSE46452 | CD276 | 80381 | 3 | 7 | 49 | |
| GSE47630 | CD276 | 80381 | 8 | 10 | 22 | |
| GSE54993 | CD276 | 80381 | 5 | 6 | 59 | |
| GSE54994 | CD276 | 80381 | 5 | 8 | 40 | |
| GSE60625 | CD276 | 80381 | 4 | 0 | 7 | |
| GSE74703 | CD276 | 80381 | 4 | 3 | 29 | |
| GSE74704 | CD276 | 80381 | 4 | 0 | 16 | |
| TCGA | CD276 | 80381 | 12 | 15 | 69 |
Total number of gains: 65; Total number of losses: 55; Total Number of normals: 368.
Somatic mutations of CD276:
Generating mutation plots.
Highly correlated genes for CD276:
Showing top 20/710 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD276 | COLGALT1 | 0.857627 | 4 | 0 | 4 |
| CD276 | DNMT1 | 0.821334 | 4 | 0 | 4 |
| CD276 | ITPR3 | 0.816514 | 4 | 0 | 4 |
| CD276 | CDC25B | 0.815969 | 4 | 0 | 4 |
| CD276 | RPL39L | 0.807847 | 4 | 0 | 4 |
| CD276 | NELL2 | 0.805883 | 4 | 0 | 4 |
| CD276 | ODF2 | 0.805685 | 4 | 0 | 4 |
| CD276 | MMP10 | 0.800405 | 5 | 0 | 5 |
| CD276 | TENM2 | 0.799733 | 3 | 0 | 3 |
| CD276 | COL4A1 | 0.796611 | 4 | 0 | 4 |
| CD276 | SH3BP4 | 0.784264 | 5 | 0 | 5 |
| CD276 | MCM3 | 0.780046 | 3 | 0 | 3 |
| CD276 | TMEM184B | 0.779614 | 5 | 0 | 5 |
| CD276 | CEP78 | 0.779278 | 4 | 0 | 4 |
| CD276 | PLXNA1 | 0.776062 | 4 | 0 | 4 |
| CD276 | PLOD1 | 0.77599 | 5 | 0 | 5 |
| CD276 | PTHLH | 0.774067 | 5 | 0 | 5 |
| CD276 | CENPW | 0.772633 | 3 | 0 | 3 |
| CD276 | LARP6 | 0.772617 | 5 | 0 | 5 |
| CD276 | TUBA1C | 0.765872 | 4 | 0 | 4 |
For details and further investigation, click here
