| Full name: hes related family bHLH transcription factor with YRPW motif 1 | Alias Symbol: HESR-1|CHF2|HESR1|HRT-1|CHF-2|HERP2|bHLHb31 | ||
| Type: protein-coding gene | Cytoband: 8q21.13 | ||
| Entrez ID: 23462 | HGNC ID: HGNC:4880 | Ensembl Gene: ENSG00000164683 | OMIM ID: 602953 |
| Drug and gene relationship at DGIdb | |||
Expression of HEY1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HEY1 | 23462 | 44783_s_at | 0.6707 | 0.4368 | |
| GSE20347 | HEY1 | 23462 | 44783_s_at | 2.3468 | 0.0000 | |
| GSE23400 | HEY1 | 23462 | 44783_s_at | 1.5280 | 0.0000 | |
| GSE26886 | HEY1 | 23462 | 44783_s_at | 3.1054 | 0.0000 | |
| GSE29001 | HEY1 | 23462 | 44783_s_at | 2.1628 | 0.0023 | |
| GSE38129 | HEY1 | 23462 | 44783_s_at | 2.4275 | 0.0000 | |
| GSE45670 | HEY1 | 23462 | 44783_s_at | 1.0182 | 0.0637 | |
| GSE53622 | HEY1 | 23462 | 934 | 1.8941 | 0.0000 | |
| GSE53624 | HEY1 | 23462 | 934 | 2.3318 | 0.0000 | |
| GSE63941 | HEY1 | 23462 | 44783_s_at | 2.7135 | 0.0956 | |
| GSE77861 | HEY1 | 23462 | 44783_s_at | 2.1063 | 0.0013 | |
| GSE97050 | HEY1 | 23462 | A_32_P83845 | 1.1297 | 0.0620 | |
| SRP007169 | HEY1 | 23462 | RNAseq | 6.7087 | 0.0000 | |
| SRP008496 | HEY1 | 23462 | RNAseq | 5.8963 | 0.0000 | |
| SRP064894 | HEY1 | 23462 | RNAseq | 2.1052 | 0.0000 | |
| SRP133303 | HEY1 | 23462 | RNAseq | 2.0835 | 0.0000 | |
| SRP159526 | HEY1 | 23462 | RNAseq | 2.8122 | 0.0000 | |
| SRP219564 | HEY1 | 23462 | RNAseq | 2.3239 | 0.0002 | |
| TCGA | HEY1 | 23462 | RNAseq | 0.7500 | 0.0000 |
Upregulated datasets: 14; Downregulated datasets: 0.
Survival by HEY1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HEY1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HEY1 | 23462 | 16 | 0 | 14 | |
| GSE20123 | HEY1 | 23462 | 18 | 0 | 12 | |
| GSE43470 | HEY1 | 23462 | 18 | 1 | 24 | |
| GSE46452 | HEY1 | 23462 | 21 | 0 | 38 | |
| GSE47630 | HEY1 | 23462 | 23 | 0 | 17 | |
| GSE54993 | HEY1 | 23462 | 0 | 19 | 51 | |
| GSE54994 | HEY1 | 23462 | 30 | 0 | 23 | |
| GSE60625 | HEY1 | 23462 | 0 | 4 | 7 | |
| GSE74703 | HEY1 | 23462 | 15 | 1 | 20 | |
| GSE74704 | HEY1 | 23462 | 12 | 0 | 8 | |
| TCGA | HEY1 | 23462 | 50 | 3 | 43 |
Total number of gains: 203; Total number of losses: 28; Total Number of normals: 257.
Somatic mutations of HEY1:
Generating mutation plots.
Highly correlated genes for HEY1:
Showing top 20/1665 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HEY1 | SSBP4 | 0.783658 | 4 | 0 | 4 |
| HEY1 | AKR1B1 | 0.739843 | 9 | 0 | 9 |
| HEY1 | ETV5 | 0.73744 | 12 | 0 | 11 |
| HEY1 | PLXNA1 | 0.737182 | 10 | 0 | 10 |
| HEY1 | ZNF664 | 0.732836 | 3 | 0 | 3 |
| HEY1 | DHRSX | 0.727371 | 3 | 0 | 3 |
| HEY1 | TCF3 | 0.724347 | 11 | 0 | 10 |
| HEY1 | SOX4 | 0.716309 | 12 | 0 | 11 |
| HEY1 | FLVCR1 | 0.711741 | 6 | 0 | 6 |
| HEY1 | PFN2 | 0.710284 | 11 | 0 | 10 |
| HEY1 | ECE1 | 0.708749 | 11 | 0 | 11 |
| HEY1 | MMS22L | 0.707964 | 3 | 0 | 3 |
| HEY1 | CDCA2 | 0.705497 | 4 | 0 | 3 |
| HEY1 | LAPTM4B | 0.70392 | 11 | 0 | 10 |
| HEY1 | TMC7 | 0.701323 | 3 | 0 | 3 |
| HEY1 | TRIB2 | 0.700173 | 11 | 0 | 11 |
| HEY1 | SHISA2 | 0.699511 | 7 | 0 | 6 |
| HEY1 | PXDN | 0.699346 | 11 | 0 | 11 |
| HEY1 | NF1 | 0.698255 | 3 | 0 | 3 |
| HEY1 | MARCKSL1 | 0.697357 | 11 | 0 | 10 |
For details and further investigation, click here
