| Full name: tripartite motif containing 21 | Alias Symbol: RNF81|RO52 | ||
| Type: protein-coding gene | Cytoband: 11p15.5-p15.3 | ||
| Entrez ID: 6737 | HGNC ID: HGNC:11312 | Ensembl Gene: ENSG00000132109 | OMIM ID: 109092 |
| Drug and gene relationship at DGIdb | |||
Expression of TRIM21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRIM21 | 6737 | 204804_at | 0.2008 | 0.7150 | |
| GSE20347 | TRIM21 | 6737 | 204804_at | 0.1413 | 0.3070 | |
| GSE23400 | TRIM21 | 6737 | 204804_at | 0.1164 | 0.0150 | |
| GSE26886 | TRIM21 | 6737 | 204804_at | -0.2117 | 0.3850 | |
| GSE29001 | TRIM21 | 6737 | 204804_at | 0.3167 | 0.1280 | |
| GSE38129 | TRIM21 | 6737 | 204804_at | 0.0249 | 0.8405 | |
| GSE45670 | TRIM21 | 6737 | 204804_at | 0.8103 | 0.0008 | |
| GSE53622 | TRIM21 | 6737 | 139242 | 0.5386 | 0.0000 | |
| GSE53624 | TRIM21 | 6737 | 139242 | 0.5765 | 0.0000 | |
| GSE63941 | TRIM21 | 6737 | 204804_at | -0.0667 | 0.9027 | |
| GSE77861 | TRIM21 | 6737 | 204804_at | 0.0975 | 0.6139 | |
| GSE97050 | TRIM21 | 6737 | A_23_P47691 | 0.4901 | 0.2624 | |
| SRP007169 | TRIM21 | 6737 | RNAseq | 0.9779 | 0.0178 | |
| SRP008496 | TRIM21 | 6737 | RNAseq | 0.5567 | 0.0747 | |
| SRP064894 | TRIM21 | 6737 | RNAseq | 0.7090 | 0.0012 | |
| SRP133303 | TRIM21 | 6737 | RNAseq | 0.3742 | 0.0672 | |
| SRP159526 | TRIM21 | 6737 | RNAseq | -0.4820 | 0.1101 | |
| SRP193095 | TRIM21 | 6737 | RNAseq | 0.1415 | 0.3671 | |
| SRP219564 | TRIM21 | 6737 | RNAseq | 0.3584 | 0.4505 | |
| TCGA | TRIM21 | 6737 | RNAseq | 0.1100 | 0.1977 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TRIM21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRIM21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRIM21 | 6737 | 1 | 12 | 17 | |
| GSE20123 | TRIM21 | 6737 | 1 | 12 | 17 | |
| GSE43470 | TRIM21 | 6737 | 1 | 8 | 34 | |
| GSE46452 | TRIM21 | 6737 | 7 | 8 | 44 | |
| GSE47630 | TRIM21 | 6737 | 3 | 13 | 24 | |
| GSE54993 | TRIM21 | 6737 | 3 | 1 | 66 | |
| GSE54994 | TRIM21 | 6737 | 1 | 12 | 40 | |
| GSE60625 | TRIM21 | 6737 | 0 | 0 | 11 | |
| GSE74703 | TRIM21 | 6737 | 1 | 6 | 29 | |
| GSE74704 | TRIM21 | 6737 | 0 | 8 | 12 | |
| TCGA | TRIM21 | 6737 | 7 | 39 | 50 |
Total number of gains: 25; Total number of losses: 119; Total Number of normals: 344.
Somatic mutations of TRIM21:
Generating mutation plots.
Highly correlated genes for TRIM21:
Showing top 20/417 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRIM21 | ECSIT | 0.755653 | 3 | 0 | 3 |
| TRIM21 | THADA | 0.750896 | 3 | 0 | 3 |
| TRIM21 | ZFYVE26 | 0.736268 | 3 | 0 | 3 |
| TRIM21 | CMPK2 | 0.736154 | 6 | 0 | 6 |
| TRIM21 | IFNGR2 | 0.734897 | 3 | 0 | 3 |
| TRIM21 | GCDH | 0.726925 | 3 | 0 | 3 |
| TRIM21 | CASKIN2 | 0.716843 | 3 | 0 | 3 |
| TRIM21 | NPRL3 | 0.715896 | 3 | 0 | 3 |
| TRIM21 | KHSRP | 0.713261 | 3 | 0 | 3 |
| TRIM21 | FAM131B | 0.711844 | 3 | 0 | 3 |
| TRIM21 | FBXO6 | 0.710998 | 6 | 0 | 6 |
| TRIM21 | RNF213 | 0.701914 | 6 | 0 | 5 |
| TRIM21 | CD80 | 0.700745 | 4 | 0 | 4 |
| TRIM21 | THSD1 | 0.699444 | 3 | 0 | 3 |
| TRIM21 | ETV6 | 0.69932 | 3 | 0 | 3 |
| TRIM21 | SLC29A3 | 0.697635 | 4 | 0 | 3 |
| TRIM21 | RSPRY1 | 0.69701 | 3 | 0 | 3 |
| TRIM21 | TNRC6B | 0.69412 | 3 | 0 | 3 |
| TRIM21 | MRPL24 | 0.691503 | 3 | 0 | 3 |
| TRIM21 | KEAP1 | 0.691403 | 3 | 0 | 3 |
For details and further investigation, click here
