| Full name: endothelin 3 | Alias Symbol: ET3 | ||
| Type: protein-coding gene | Cytoband: 20q13.32 | ||
| Entrez ID: 1908 | HGNC ID: HGNC:3178 | Ensembl Gene: ENSG00000124205 | OMIM ID: 131242 |
| Drug and gene relationship at DGIdb | |||
Expression of EDN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EDN3 | 1908 | 208399_s_at | -4.6325 | 0.0102 | |
| GSE20347 | EDN3 | 1908 | 208399_s_at | -1.7812 | 0.0000 | |
| GSE23400 | EDN3 | 1908 | 208399_s_at | -0.8031 | 0.0000 | |
| GSE26886 | EDN3 | 1908 | 208399_s_at | -2.3876 | 0.0004 | |
| GSE29001 | EDN3 | 1908 | 208399_s_at | -2.2760 | 0.0000 | |
| GSE38129 | EDN3 | 1908 | 208399_s_at | -1.7138 | 0.0000 | |
| GSE45670 | EDN3 | 1908 | 208399_s_at | -3.4816 | 0.0000 | |
| GSE53622 | EDN3 | 1908 | 13875 | -3.0305 | 0.0000 | |
| GSE53624 | EDN3 | 1908 | 13875 | -2.7058 | 0.0000 | |
| GSE63941 | EDN3 | 1908 | 217154_s_at | 0.1294 | 0.3972 | |
| GSE77861 | EDN3 | 1908 | 208399_s_at | -1.5563 | 0.0003 | |
| GSE97050 | EDN3 | 1908 | A_33_P3397288 | -1.2109 | 0.1781 | |
| SRP007169 | EDN3 | 1908 | RNAseq | -9.9922 | 0.0000 | |
| SRP064894 | EDN3 | 1908 | RNAseq | -6.2603 | 0.0000 | |
| SRP133303 | EDN3 | 1908 | RNAseq | -4.6093 | 0.0000 | |
| SRP159526 | EDN3 | 1908 | RNAseq | -1.3478 | 0.3832 | |
| SRP193095 | EDN3 | 1908 | RNAseq | -3.8234 | 0.0000 | |
| SRP219564 | EDN3 | 1908 | RNAseq | -3.9364 | 0.0019 | |
| TCGA | EDN3 | 1908 | RNAseq | -1.0554 | 0.2819 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by EDN3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EDN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EDN3 | 1908 | 13 | 2 | 15 | |
| GSE20123 | EDN3 | 1908 | 14 | 2 | 14 | |
| GSE43470 | EDN3 | 1908 | 13 | 0 | 30 | |
| GSE46452 | EDN3 | 1908 | 29 | 0 | 30 | |
| GSE47630 | EDN3 | 1908 | 24 | 1 | 15 | |
| GSE54993 | EDN3 | 1908 | 0 | 17 | 53 | |
| GSE54994 | EDN3 | 1908 | 29 | 0 | 24 | |
| GSE60625 | EDN3 | 1908 | 0 | 0 | 11 | |
| GSE74703 | EDN3 | 1908 | 11 | 0 | 25 | |
| GSE74704 | EDN3 | 1908 | 11 | 0 | 9 | |
| TCGA | EDN3 | 1908 | 43 | 4 | 49 |
Total number of gains: 187; Total number of losses: 26; Total Number of normals: 275.
Somatic mutations of EDN3:
Generating mutation plots.
Highly correlated genes for EDN3:
Showing top 20/1313 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EDN3 | MYZAP | 0.801733 | 3 | 0 | 3 |
| EDN3 | SLC6A1 | 0.777091 | 10 | 0 | 10 |
| EDN3 | CTTNBP2 | 0.769444 | 7 | 0 | 7 |
| EDN3 | MAPT | 0.760641 | 10 | 0 | 10 |
| EDN3 | KRT78 | 0.750745 | 7 | 0 | 7 |
| EDN3 | HCG22 | 0.748621 | 6 | 0 | 6 |
| EDN3 | UPK1A | 0.748017 | 11 | 0 | 11 |
| EDN3 | MORN3 | 0.746946 | 4 | 0 | 4 |
| EDN3 | ZNF536 | 0.746456 | 4 | 0 | 4 |
| EDN3 | VSIG2 | 0.745088 | 7 | 0 | 7 |
| EDN3 | UBL3 | 0.741803 | 11 | 0 | 11 |
| EDN3 | SNORA68 | 0.741429 | 4 | 0 | 4 |
| EDN3 | NFIX | 0.740153 | 5 | 0 | 5 |
| EDN3 | ZNF662 | 0.738943 | 6 | 0 | 6 |
| EDN3 | SUMF1 | 0.737631 | 4 | 0 | 4 |
| EDN3 | TFAP2B | 0.736727 | 10 | 0 | 9 |
| EDN3 | SH3BGRL2 | 0.733867 | 8 | 0 | 7 |
| EDN3 | FAM219B | 0.732373 | 4 | 0 | 4 |
| EDN3 | PCBP1-AS1 | 0.729303 | 5 | 0 | 5 |
| EDN3 | FAM214A | 0.728722 | 6 | 0 | 6 |
For details and further investigation, click here
