| Full name: transcription factor AP-2 beta | Alias Symbol: AP2-B | ||
| Type: protein-coding gene | Cytoband: 6p12.3 | ||
| Entrez ID: 7021 | HGNC ID: HGNC:11743 | Ensembl Gene: ENSG00000008196 | OMIM ID: 601601 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of TFAP2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TFAP2B | 7021 | 214451_at | -3.9655 | 0.0036 | |
| GSE20347 | TFAP2B | 7021 | 214451_at | -3.6571 | 0.0000 | |
| GSE23400 | TFAP2B | 7021 | 215686_x_at | -0.1250 | 0.0000 | |
| GSE26886 | TFAP2B | 7021 | 214451_at | -2.0980 | 0.0007 | |
| GSE29001 | TFAP2B | 7021 | 214451_at | -4.5455 | 0.0000 | |
| GSE38129 | TFAP2B | 7021 | 214451_at | -2.7774 | 0.0000 | |
| GSE45670 | TFAP2B | 7021 | 214451_at | -3.4588 | 0.0000 | |
| GSE53622 | TFAP2B | 7021 | 137944 | -4.3126 | 0.0000 | |
| GSE53624 | TFAP2B | 7021 | 137944 | -5.2100 | 0.0000 | |
| GSE63941 | TFAP2B | 7021 | 214451_at | 0.2585 | 0.2297 | |
| GSE77861 | TFAP2B | 7021 | 214451_at | -1.6478 | 0.0016 | |
| SRP064894 | TFAP2B | 7021 | RNAseq | -6.1736 | 0.0000 | |
| SRP133303 | TFAP2B | 7021 | RNAseq | -4.1795 | 0.0000 | |
| SRP159526 | TFAP2B | 7021 | RNAseq | -3.4264 | 0.0001 | |
| TCGA | TFAP2B | 7021 | RNAseq | 0.2154 | 0.8422 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by TFAP2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TFAP2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TFAP2B | 7021 | 6 | 2 | 22 | |
| GSE20123 | TFAP2B | 7021 | 6 | 2 | 22 | |
| GSE43470 | TFAP2B | 7021 | 5 | 0 | 38 | |
| GSE46452 | TFAP2B | 7021 | 3 | 10 | 46 | |
| GSE47630 | TFAP2B | 7021 | 7 | 5 | 28 | |
| GSE54993 | TFAP2B | 7021 | 3 | 1 | 66 | |
| GSE54994 | TFAP2B | 7021 | 8 | 4 | 41 | |
| GSE60625 | TFAP2B | 7021 | 0 | 3 | 8 | |
| GSE74703 | TFAP2B | 7021 | 5 | 0 | 31 | |
| GSE74704 | TFAP2B | 7021 | 2 | 1 | 17 | |
| TCGA | TFAP2B | 7021 | 20 | 13 | 63 |
Total number of gains: 65; Total number of losses: 41; Total Number of normals: 382.
Somatic mutations of TFAP2B:
Generating mutation plots.
Highly correlated genes for TFAP2B:
Showing top 20/1595 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TFAP2B | PAQR8 | 0.830566 | 6 | 0 | 6 |
| TFAP2B | CRISP3 | 0.823414 | 10 | 0 | 10 |
| TFAP2B | HCG22 | 0.818905 | 6 | 0 | 6 |
| TFAP2B | KRT78 | 0.814491 | 6 | 0 | 6 |
| TFAP2B | SFTA2 | 0.80863 | 4 | 0 | 4 |
| TFAP2B | DLG2 | 0.8081 | 9 | 0 | 9 |
| TFAP2B | SIM2 | 0.806307 | 10 | 0 | 10 |
| TFAP2B | FCER1A | 0.805785 | 8 | 0 | 8 |
| TFAP2B | SLC16A6 | 0.802526 | 10 | 0 | 10 |
| TFAP2B | ENDOU | 0.801983 | 10 | 0 | 10 |
| TFAP2B | FAM3D | 0.801093 | 6 | 0 | 6 |
| TFAP2B | SAMD5 | 0.798456 | 6 | 0 | 6 |
| TFAP2B | SMDT1 | 0.79788 | 4 | 0 | 4 |
| TFAP2B | SCNN1B | 0.795036 | 10 | 0 | 10 |
| TFAP2B | HPGD | 0.795022 | 10 | 0 | 10 |
| TFAP2B | FCHO2 | 0.79413 | 6 | 0 | 6 |
| TFAP2B | SHROOM3 | 0.792278 | 6 | 0 | 6 |
| TFAP2B | TMPRSS11B | 0.788655 | 6 | 0 | 6 |
| TFAP2B | CAB39L | 0.787334 | 10 | 0 | 10 |
| TFAP2B | SPINK7 | 0.784161 | 7 | 0 | 7 |
For details and further investigation, click here
