| Full name: uroplakin 1A | Alias Symbol: TSPAN21 | ||
| Type: protein-coding gene | Cytoband: 19q13.12 | ||
| Entrez ID: 11045 | HGNC ID: HGNC:12577 | Ensembl Gene: ENSG00000105668 | OMIM ID: 611557 |
| Drug and gene relationship at DGIdb | |||
Expression of UPK1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UPK1A | 11045 | 214624_at | -2.8054 | 0.0339 | |
| GSE20347 | UPK1A | 11045 | 214624_at | -2.9596 | 0.0000 | |
| GSE23400 | UPK1A | 11045 | 214624_at | -1.9458 | 0.0000 | |
| GSE26886 | UPK1A | 11045 | 214624_at | -4.2959 | 0.0000 | |
| GSE29001 | UPK1A | 11045 | 214624_at | -4.5554 | 0.0000 | |
| GSE38129 | UPK1A | 11045 | 214624_at | -2.4407 | 0.0000 | |
| GSE45670 | UPK1A | 11045 | 214624_at | -2.1838 | 0.0015 | |
| GSE53622 | UPK1A | 11045 | 76504 | -3.6770 | 0.0000 | |
| GSE53624 | UPK1A | 11045 | 76504 | -4.0871 | 0.0000 | |
| GSE63941 | UPK1A | 11045 | 214624_at | -0.2081 | 0.6043 | |
| GSE77861 | UPK1A | 11045 | 214624_at | -2.7177 | 0.0047 | |
| GSE97050 | UPK1A | 11045 | A_23_P119634 | -1.5731 | 0.2280 | |
| SRP007169 | UPK1A | 11045 | RNAseq | -7.8043 | 0.0000 | |
| SRP008496 | UPK1A | 11045 | RNAseq | -7.4910 | 0.0000 | |
| SRP064894 | UPK1A | 11045 | RNAseq | -4.7418 | 0.0000 | |
| SRP133303 | UPK1A | 11045 | RNAseq | -6.1245 | 0.0000 | |
| SRP159526 | UPK1A | 11045 | RNAseq | -4.8444 | 0.0000 | |
| TCGA | UPK1A | 11045 | RNAseq | -0.7026 | 0.4072 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by UPK1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UPK1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UPK1A | 11045 | 6 | 4 | 20 | |
| GSE20123 | UPK1A | 11045 | 6 | 3 | 21 | |
| GSE43470 | UPK1A | 11045 | 3 | 7 | 33 | |
| GSE46452 | UPK1A | 11045 | 48 | 1 | 10 | |
| GSE47630 | UPK1A | 11045 | 9 | 5 | 26 | |
| GSE54993 | UPK1A | 11045 | 17 | 3 | 50 | |
| GSE54994 | UPK1A | 11045 | 7 | 9 | 37 | |
| GSE60625 | UPK1A | 11045 | 9 | 0 | 2 | |
| GSE74703 | UPK1A | 11045 | 3 | 4 | 29 | |
| GSE74704 | UPK1A | 11045 | 6 | 1 | 13 | |
| TCGA | UPK1A | 11045 | 22 | 10 | 64 |
Total number of gains: 136; Total number of losses: 47; Total Number of normals: 305.
Somatic mutations of UPK1A:
Generating mutation plots.
Highly correlated genes for UPK1A:
Showing top 20/1652 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UPK1A | KRT78 | 0.890038 | 7 | 0 | 7 |
| UPK1A | NCCRP1 | 0.889754 | 3 | 0 | 3 |
| UPK1A | GDPD3 | 0.881608 | 11 | 0 | 11 |
| UPK1A | SCNN1B | 0.878473 | 11 | 0 | 11 |
| UPK1A | GYS2 | 0.877804 | 10 | 0 | 10 |
| UPK1A | HCG22 | 0.877617 | 6 | 0 | 6 |
| UPK1A | CYSRT1 | 0.876763 | 6 | 0 | 6 |
| UPK1A | SPINK7 | 0.876048 | 7 | 0 | 7 |
| UPK1A | RMND5B | 0.875294 | 10 | 0 | 10 |
| UPK1A | ECM1 | 0.873499 | 11 | 0 | 11 |
| UPK1A | PRSS27 | 0.872725 | 7 | 0 | 7 |
| UPK1A | SLURP1 | 0.872623 | 11 | 0 | 11 |
| UPK1A | PADI1 | 0.872117 | 8 | 0 | 8 |
| UPK1A | EPS8L1 | 0.871895 | 11 | 0 | 11 |
| UPK1A | IL36A | 0.870862 | 11 | 0 | 11 |
| UPK1A | VSIG10L | 0.869937 | 7 | 0 | 7 |
| UPK1A | FAM3D | 0.866927 | 7 | 0 | 7 |
| UPK1A | SLC16A6 | 0.864631 | 10 | 0 | 10 |
| UPK1A | CRISP3 | 0.862248 | 11 | 0 | 11 |
| UPK1A | TMPRSS11B | 0.861819 | 7 | 0 | 7 |
For details and further investigation, click here
