| Full name: solute carrier family 6 member 1 | Alias Symbol: GAT1|GABATR|GABATHG | ||
| Type: protein-coding gene | Cytoband: 3p25.3 | ||
| Entrez ID: 6529 | HGNC ID: HGNC:11042 | Ensembl Gene: ENSG00000157103 | OMIM ID: 137165 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC6A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC6A1 | 6529 | 205152_at | -3.7917 | 0.0036 | |
| GSE20347 | SLC6A1 | 6529 | 205152_at | -1.3637 | 0.0000 | |
| GSE23400 | SLC6A1 | 6529 | 205152_at | -0.3282 | 0.0000 | |
| GSE26886 | SLC6A1 | 6529 | 205152_at | -1.9498 | 0.0000 | |
| GSE29001 | SLC6A1 | 6529 | 205152_at | -1.6813 | 0.0000 | |
| GSE38129 | SLC6A1 | 6529 | 205152_at | -1.1417 | 0.0000 | |
| GSE45670 | SLC6A1 | 6529 | 205152_at | -2.5045 | 0.0000 | |
| GSE53622 | SLC6A1 | 6529 | 100224 | -2.7526 | 0.0000 | |
| GSE53624 | SLC6A1 | 6529 | 100224 | -3.1006 | 0.0000 | |
| GSE63941 | SLC6A1 | 6529 | 205152_at | 0.0708 | 0.5758 | |
| GSE77861 | SLC6A1 | 6529 | 205152_at | -0.5974 | 0.0296 | |
| SRP064894 | SLC6A1 | 6529 | RNAseq | -2.2508 | 0.0000 | |
| SRP133303 | SLC6A1 | 6529 | RNAseq | -2.7348 | 0.0000 | |
| SRP159526 | SLC6A1 | 6529 | RNAseq | -3.3360 | 0.0000 | |
| SRP219564 | SLC6A1 | 6529 | RNAseq | -3.0233 | 0.0000 | |
| TCGA | SLC6A1 | 6529 | RNAseq | -0.0039 | 0.9908 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by SLC6A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC6A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC6A1 | 6529 | 1 | 18 | 11 | |
| GSE20123 | SLC6A1 | 6529 | 1 | 19 | 10 | |
| GSE43470 | SLC6A1 | 6529 | 0 | 21 | 22 | |
| GSE46452 | SLC6A1 | 6529 | 2 | 17 | 40 | |
| GSE47630 | SLC6A1 | 6529 | 2 | 23 | 15 | |
| GSE54993 | SLC6A1 | 6529 | 6 | 1 | 63 | |
| GSE54994 | SLC6A1 | 6529 | 2 | 32 | 19 | |
| GSE60625 | SLC6A1 | 6529 | 5 | 0 | 6 | |
| GSE74703 | SLC6A1 | 6529 | 0 | 17 | 19 | |
| GSE74704 | SLC6A1 | 6529 | 1 | 10 | 9 | |
| TCGA | SLC6A1 | 6529 | 3 | 67 | 26 |
Total number of gains: 23; Total number of losses: 225; Total Number of normals: 240.
Somatic mutations of SLC6A1:
Generating mutation plots.
Highly correlated genes for SLC6A1:
Showing top 20/1484 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC6A1 | TMEM61 | 0.779461 | 3 | 0 | 3 |
| SLC6A1 | EDN3 | 0.777091 | 10 | 0 | 10 |
| SLC6A1 | ANKRD35 | 0.770192 | 6 | 0 | 6 |
| SLC6A1 | SAMD5 | 0.767349 | 6 | 0 | 6 |
| SLC6A1 | TCP11L2 | 0.767091 | 4 | 0 | 4 |
| SLC6A1 | MPP7 | 0.766249 | 6 | 0 | 6 |
| SLC6A1 | ENDOU | 0.76285 | 10 | 0 | 10 |
| SLC6A1 | FCHO2 | 0.762661 | 6 | 0 | 6 |
| SLC6A1 | SLC46A2 | 0.760687 | 6 | 0 | 6 |
| SLC6A1 | BBOX1 | 0.759221 | 10 | 0 | 10 |
| SLC6A1 | FAM3D | 0.75877 | 6 | 0 | 6 |
| SLC6A1 | TMPRSS11B | 0.758589 | 6 | 0 | 6 |
| SLC6A1 | ZNF503-AS1 | 0.757812 | 6 | 0 | 6 |
| SLC6A1 | UBL3 | 0.757029 | 10 | 0 | 10 |
| SLC6A1 | SASH1 | 0.756783 | 10 | 0 | 10 |
| SLC6A1 | CYSRT1 | 0.755316 | 6 | 0 | 6 |
| SLC6A1 | SIM2 | 0.7545 | 10 | 0 | 10 |
| SLC6A1 | RBM20 | 0.754387 | 4 | 0 | 4 |
| SLC6A1 | GDPD3 | 0.75286 | 10 | 0 | 10 |
| SLC6A1 | CXCR2 | 0.752827 | 10 | 0 | 10 |
For details and further investigation, click here
