| Full name: keratin 78 | Alias Symbol: K5B | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 196374 | HGNC ID: HGNC:28926 | Ensembl Gene: ENSG00000170423 | OMIM ID: 611159 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KRT78:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KRT78 | 196374 | 1553212_at | -4.3642 | 0.0274 | |
| GSE26886 | KRT78 | 196374 | 1553212_at | -6.9265 | 0.0000 | |
| GSE45670 | KRT78 | 196374 | 1553212_at | -1.9730 | 0.0076 | |
| GSE53622 | KRT78 | 196374 | 60768 | -2.3061 | 0.0000 | |
| GSE53624 | KRT78 | 196374 | 60768 | -2.0948 | 0.0000 | |
| GSE63941 | KRT78 | 196374 | 1553212_at | -0.0689 | 0.7830 | |
| GSE77861 | KRT78 | 196374 | 1553212_at | -2.6606 | 0.0011 | |
| GSE97050 | KRT78 | 196374 | A_33_P3315268 | -1.3902 | 0.1239 | |
| SRP007169 | KRT78 | 196374 | RNAseq | -9.6888 | 0.0000 | |
| SRP008496 | KRT78 | 196374 | RNAseq | -8.4168 | 0.0000 | |
| SRP064894 | KRT78 | 196374 | RNAseq | -6.3488 | 0.0000 | |
| SRP133303 | KRT78 | 196374 | RNAseq | -7.2189 | 0.0000 | |
| SRP159526 | KRT78 | 196374 | RNAseq | -7.5534 | 0.0000 | |
| SRP219564 | KRT78 | 196374 | RNAseq | -6.2371 | 0.0000 | |
| TCGA | KRT78 | 196374 | RNAseq | -0.0308 | 0.9552 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by KRT78 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KRT78:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KRT78 | 196374 | 8 | 1 | 21 | |
| GSE20123 | KRT78 | 196374 | 8 | 1 | 21 | |
| GSE43470 | KRT78 | 196374 | 3 | 0 | 40 | |
| GSE46452 | KRT78 | 196374 | 7 | 1 | 51 | |
| GSE47630 | KRT78 | 196374 | 10 | 2 | 28 | |
| GSE54993 | KRT78 | 196374 | 0 | 5 | 65 | |
| GSE54994 | KRT78 | 196374 | 4 | 1 | 48 | |
| GSE60625 | KRT78 | 196374 | 0 | 0 | 11 | |
| GSE74703 | KRT78 | 196374 | 3 | 0 | 33 | |
| GSE74704 | KRT78 | 196374 | 5 | 1 | 14 | |
| TCGA | KRT78 | 196374 | 13 | 11 | 72 |
Total number of gains: 61; Total number of losses: 23; Total Number of normals: 404.
Somatic mutations of KRT78:
Generating mutation plots.
Highly correlated genes for KRT78:
Showing top 20/1761 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KRT78 | ENDOU | 0.918121 | 7 | 0 | 7 |
| KRT78 | CRISP3 | 0.917683 | 7 | 0 | 7 |
| KRT78 | UBL3 | 0.912404 | 7 | 0 | 7 |
| KRT78 | TMPRSS11B | 0.907653 | 8 | 0 | 8 |
| KRT78 | EPS8L1 | 0.898034 | 8 | 0 | 8 |
| KRT78 | ECM1 | 0.896807 | 8 | 0 | 8 |
| KRT78 | ANXA9 | 0.892962 | 7 | 0 | 7 |
| KRT78 | PRSS27 | 0.890629 | 8 | 0 | 8 |
| KRT78 | UPK1A | 0.890038 | 7 | 0 | 7 |
| KRT78 | NUCB2 | 0.888197 | 7 | 0 | 7 |
| KRT78 | VSIG10L | 0.887822 | 7 | 0 | 7 |
| KRT78 | ABLIM1 | 0.887365 | 7 | 0 | 7 |
| KRT78 | SMIM5 | 0.884063 | 6 | 0 | 6 |
| KRT78 | ABLIM3 | 0.881275 | 6 | 0 | 6 |
| KRT78 | FAM3D | 0.881239 | 8 | 0 | 8 |
| KRT78 | SPINK7 | 0.879086 | 8 | 0 | 8 |
| KRT78 | TMOD3 | 0.878896 | 7 | 0 | 7 |
| KRT78 | IL36A | 0.876633 | 7 | 0 | 7 |
| KRT78 | CRNN | 0.876062 | 8 | 0 | 8 |
| KRT78 | MGLL | 0.876032 | 7 | 0 | 7 |
For details and further investigation, click here
