EFNA4

 

Full name: ephrin A4 Alias Symbol: LERK4
Type: protein-coding gene Cytoband: 1q21.3
Entrez ID: 1945 HGNC ID: HGNC:3224 Ensembl Gene: ENSG00000243364 OMIM ID: 601380
Drug and gene relationship at DGIdb

 

EFNA4 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04360Axon guidance

 

Expression of EFNA4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 EFNA4 1945 205107_s_at 0.5793 0.2143
GSE20347 EFNA4 1945 205107_s_at 0.0922 0.5819
GSE23400 EFNA4 1945 205107_s_at 0.2100 0.0026
GSE26886 EFNA4 1945 205107_s_at 0.6249 0.0035
GSE29001 EFNA4 1945 205107_s_at 0.2904 0.1659
GSE38129 EFNA4 1945 205107_s_at 0.5391 0.0089
GSE45670 EFNA4 1945 205107_s_at 0.3260 0.0194
GSE53622 EFNA4 1945 25999 0.4275 0.0000
GSE53624 EFNA4 1945 25999 0.3365 0.0000
GSE63941 EFNA4 1945 205107_s_at 0.4821 0.3997
GSE77861 EFNA4 1945 205107_s_at 0.1651 0.4374
GSE97050 EFNA4 1945 A_23_P322 0.2899 0.4039
SRP007169 EFNA4 1945 RNAseq -1.1607 0.0047
SRP008496 EFNA4 1945 RNAseq -0.1183 0.7642
SRP064894 EFNA4 1945 RNAseq 0.3106 0.2636
SRP133303 EFNA4 1945 RNAseq 0.1679 0.4987
SRP159526 EFNA4 1945 RNAseq 0.9054 0.0268
SRP193095 EFNA4 1945 RNAseq 0.0047 0.9714
SRP219564 EFNA4 1945 RNAseq 0.2556 0.6960
TCGA EFNA4 1945 RNAseq 0.5160 0.0000

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by EFNA4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EFNA4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EFNA4 1945 14 0 16
GSE20123 EFNA4 1945 13 0 17
GSE43470 EFNA4 1945 6 2 35
GSE46452 EFNA4 1945 2 1 56
GSE47630 EFNA4 1945 14 0 26
GSE54993 EFNA4 1945 0 4 66
GSE54994 EFNA4 1945 16 0 37
GSE60625 EFNA4 1945 0 0 11
GSE74703 EFNA4 1945 6 1 29
GSE74704 EFNA4 1945 6 0 14
TCGA EFNA4 1945 38 2 56

Total number of gains: 115; Total number of losses: 10; Total Number of normals: 363.  

 

Somatic mutations of EFNA4:

 

Generating mutation plots.

 

Highly correlated genes for EFNA4:

 

Showing top 20/250 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EFNA4TIGD50.772505303
EFNA4C4orf470.757118303
EFNA4ARL110.747078404
EFNA4TDRD90.740396303
EFNA4HDAC80.715257303
EFNA4FBP10.714024303
EFNA4TMCO30.703608303
EFNA4IL12RB20.690469403
EFNA4CCDC1420.685975404
EFNA4TANK0.685027303
EFNA4NPW0.679062303
EFNA4ZMYND150.674615404
EFNA4WDR910.665936303
EFNA4ASCL20.659643504
EFNA4SH2D4B0.649967303
EFNA4RFESD0.647857303
EFNA4ACTL80.647648303
EFNA4HOTAIR0.644652403
EFNA4TFAP2C0.643747907
EFNA4PPP1R13B0.643156403

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