| Full name: achaete-scute family bHLH transcription factor 2 | Alias Symbol: ASH2|HASH2|bHLHa45 | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 430 | HGNC ID: HGNC:739 | Ensembl Gene: ENSG00000183734 | OMIM ID: 601886 |
| Drug and gene relationship at DGIdb | |||
Expression of ASCL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASCL2 | 430 | 229215_at | 0.8474 | 0.1900 | |
| GSE20347 | ASCL2 | 430 | 207607_at | -0.0083 | 0.8653 | |
| GSE23400 | ASCL2 | 430 | 207607_at | -0.0421 | 0.0041 | |
| GSE26886 | ASCL2 | 430 | 229215_at | 1.4938 | 0.0000 | |
| GSE29001 | ASCL2 | 430 | 207607_at | 0.0096 | 0.9160 | |
| GSE38129 | ASCL2 | 430 | 207607_at | 0.0067 | 0.8964 | |
| GSE45670 | ASCL2 | 430 | 229215_at | 1.1018 | 0.0001 | |
| GSE53622 | ASCL2 | 430 | 109665 | 0.5453 | 0.0000 | |
| GSE53624 | ASCL2 | 430 | 109665 | 0.7091 | 0.0000 | |
| GSE63941 | ASCL2 | 430 | 229215_at | 1.4788 | 0.1067 | |
| GSE77861 | ASCL2 | 430 | 229215_at | 0.3459 | 0.1870 | |
| GSE97050 | ASCL2 | 430 | A_32_P171061 | 0.5633 | 0.3840 | |
| SRP133303 | ASCL2 | 430 | RNAseq | 0.9466 | 0.0044 | |
| SRP159526 | ASCL2 | 430 | RNAseq | 1.1792 | 0.0585 | |
| SRP219564 | ASCL2 | 430 | RNAseq | 1.9840 | 0.0246 | |
| TCGA | ASCL2 | 430 | RNAseq | 1.5371 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by ASCL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ASCL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASCL2 | 430 | 1 | 11 | 18 | |
| GSE20123 | ASCL2 | 430 | 1 | 12 | 17 | |
| GSE43470 | ASCL2 | 430 | 1 | 9 | 33 | |
| GSE46452 | ASCL2 | 430 | 7 | 8 | 44 | |
| GSE47630 | ASCL2 | 430 | 4 | 12 | 24 | |
| GSE54993 | ASCL2 | 430 | 3 | 1 | 66 | |
| GSE54994 | ASCL2 | 430 | 1 | 12 | 40 | |
| GSE60625 | ASCL2 | 430 | 0 | 0 | 11 | |
| GSE74703 | ASCL2 | 430 | 1 | 7 | 28 | |
| GSE74704 | ASCL2 | 430 | 0 | 8 | 12 | |
| TCGA | ASCL2 | 430 | 8 | 39 | 49 |
Total number of gains: 27; Total number of losses: 119; Total Number of normals: 342.
Somatic mutations of ASCL2:
Generating mutation plots.
Highly correlated genes for ASCL2:
Showing top 20/274 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASCL2 | C1orf53 | 0.743606 | 3 | 0 | 3 |
| ASCL2 | ST3GAL1 | 0.723866 | 3 | 0 | 3 |
| ASCL2 | IPO4 | 0.712366 | 3 | 0 | 3 |
| ASCL2 | UBE2Q1 | 0.694335 | 3 | 0 | 3 |
| ASCL2 | XCL1 | 0.690994 | 4 | 0 | 4 |
| ASCL2 | WDPCP | 0.689155 | 3 | 0 | 3 |
| ASCL2 | LSAMP-AS1 | 0.686435 | 3 | 0 | 3 |
| ASCL2 | MYO10 | 0.686304 | 4 | 0 | 4 |
| ASCL2 | NOP14 | 0.676493 | 3 | 0 | 3 |
| ASCL2 | TRIM9 | 0.673407 | 4 | 0 | 3 |
| ASCL2 | LONP1 | 0.672227 | 5 | 0 | 4 |
| ASCL2 | C19orf53 | 0.666469 | 3 | 0 | 3 |
| ASCL2 | DPY19L4 | 0.664015 | 3 | 0 | 3 |
| ASCL2 | EFNA4 | 0.659643 | 5 | 0 | 4 |
| ASCL2 | HOXA10 | 0.654276 | 4 | 0 | 3 |
| ASCL2 | HOXC9 | 0.651805 | 4 | 0 | 4 |
| ASCL2 | FBRSL1 | 0.648903 | 4 | 0 | 3 |
| ASCL2 | ZNF77 | 0.637483 | 4 | 0 | 3 |
| ASCL2 | TMEM223 | 0.637086 | 3 | 0 | 3 |
| ASCL2 | JAKMIP2 | 0.634313 | 3 | 0 | 3 |
For details and further investigation, click here
