| Full name: interleukin 12 receptor subunit beta 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p31.3 | ||
| Entrez ID: 3595 | HGNC ID: HGNC:5972 | Ensembl Gene: ENSG00000081985 | OMIM ID: 601642 |
| Drug and gene relationship at DGIdb | |||
IL12RB2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway | |
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of IL12RB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL12RB2 | 3595 | 206999_at | 1.4122 | 0.2199 | |
| GSE20347 | IL12RB2 | 3595 | 206999_at | 0.4560 | 0.0259 | |
| GSE23400 | IL12RB2 | 3595 | 206999_at | 0.3371 | 0.0011 | |
| GSE26886 | IL12RB2 | 3595 | 206999_at | 0.3922 | 0.0408 | |
| GSE29001 | IL12RB2 | 3595 | 206999_at | 0.5944 | 0.0155 | |
| GSE38129 | IL12RB2 | 3595 | 206999_at | 0.5855 | 0.0073 | |
| GSE45670 | IL12RB2 | 3595 | 206999_at | 0.9315 | 0.0547 | |
| GSE53622 | IL12RB2 | 3595 | 63252 | 0.9742 | 0.0000 | |
| GSE53624 | IL12RB2 | 3595 | 63252 | 0.7321 | 0.0000 | |
| GSE63941 | IL12RB2 | 3595 | 206999_at | 0.3012 | 0.6780 | |
| GSE77861 | IL12RB2 | 3595 | 206999_at | 0.1998 | 0.2995 | |
| GSE97050 | IL12RB2 | 3595 | A_23_P72077 | 0.4898 | 0.1888 | |
| SRP007169 | IL12RB2 | 3595 | RNAseq | 1.9071 | 0.0228 | |
| SRP064894 | IL12RB2 | 3595 | RNAseq | 1.6085 | 0.0001 | |
| SRP133303 | IL12RB2 | 3595 | RNAseq | 1.4860 | 0.0010 | |
| SRP159526 | IL12RB2 | 3595 | RNAseq | 1.0403 | 0.0754 | |
| SRP193095 | IL12RB2 | 3595 | RNAseq | 0.7327 | 0.0033 | |
| SRP219564 | IL12RB2 | 3595 | RNAseq | 2.7635 | 0.0030 | |
| TCGA | IL12RB2 | 3595 | RNAseq | 1.4049 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by IL12RB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL12RB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL12RB2 | 3595 | 1 | 6 | 23 | |
| GSE20123 | IL12RB2 | 3595 | 1 | 5 | 24 | |
| GSE43470 | IL12RB2 | 3595 | 5 | 2 | 36 | |
| GSE46452 | IL12RB2 | 3595 | 0 | 1 | 58 | |
| GSE47630 | IL12RB2 | 3595 | 8 | 5 | 27 | |
| GSE54993 | IL12RB2 | 3595 | 0 | 0 | 70 | |
| GSE54994 | IL12RB2 | 3595 | 6 | 4 | 43 | |
| GSE60625 | IL12RB2 | 3595 | 0 | 0 | 11 | |
| GSE74703 | IL12RB2 | 3595 | 4 | 2 | 30 | |
| GSE74704 | IL12RB2 | 3595 | 1 | 2 | 17 | |
| TCGA | IL12RB2 | 3595 | 8 | 22 | 66 |
Total number of gains: 34; Total number of losses: 49; Total Number of normals: 405.
Somatic mutations of IL12RB2:
Generating mutation plots.
Highly correlated genes for IL12RB2:
Showing top 20/209 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL12RB2 | TFAP2E | 0.817066 | 3 | 0 | 3 |
| IL12RB2 | SALL3 | 0.797304 | 3 | 0 | 3 |
| IL12RB2 | GNPNAT1 | 0.79496 | 3 | 0 | 3 |
| IL12RB2 | KCNN4 | 0.777447 | 3 | 0 | 3 |
| IL12RB2 | FBRSL1 | 0.737954 | 4 | 0 | 4 |
| IL12RB2 | ZBTB24 | 0.735085 | 3 | 0 | 3 |
| IL12RB2 | TIGD5 | 0.723562 | 3 | 0 | 3 |
| IL12RB2 | FBP1 | 0.713782 | 3 | 0 | 3 |
| IL12RB2 | RNF139-AS1 | 0.711115 | 3 | 0 | 3 |
| IL12RB2 | EFR3A | 0.702228 | 3 | 0 | 3 |
| IL12RB2 | EFNA4 | 0.690469 | 4 | 0 | 3 |
| IL12RB2 | LRFN1 | 0.680735 | 4 | 0 | 3 |
| IL12RB2 | TMEM9 | 0.678532 | 3 | 0 | 3 |
| IL12RB2 | FUT1 | 0.677926 | 3 | 0 | 3 |
| IL12RB2 | C14orf93 | 0.677233 | 4 | 0 | 4 |
| IL12RB2 | TMEM68 | 0.66867 | 4 | 0 | 3 |
| IL12RB2 | OTUD4 | 0.660572 | 4 | 0 | 3 |
| IL12RB2 | TAF5L | 0.65623 | 4 | 0 | 3 |
| IL12RB2 | BATF2 | 0.653599 | 6 | 0 | 6 |
| IL12RB2 | RIN1 | 0.649101 | 4 | 0 | 3 |
For details and further investigation, click here
