| Full name: TRAF family member associated NFKB activator | Alias Symbol: I-TRAF | ||
| Type: protein-coding gene | Cytoband: 2q24.2 | ||
| Entrez ID: 10010 | HGNC ID: HGNC:11562 | Ensembl Gene: ENSG00000136560 | OMIM ID: 603893 |
| Drug and gene relationship at DGIdb | |||
TANK involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04622 | RIG-I-like receptor signaling pathway |
Expression of TANK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TANK | 10010 | 207616_s_at | 0.3745 | 0.3819 | |
| GSE20347 | TANK | 10010 | 207616_s_at | 0.1114 | 0.5753 | |
| GSE23400 | TANK | 10010 | 207616_s_at | 0.0318 | 0.5498 | |
| GSE26886 | TANK | 10010 | 207616_s_at | 0.1033 | 0.6960 | |
| GSE29001 | TANK | 10010 | 209451_at | 0.4777 | 0.2327 | |
| GSE38129 | TANK | 10010 | 207616_s_at | 0.0560 | 0.8083 | |
| GSE45670 | TANK | 10010 | 209451_at | 0.1479 | 0.4201 | |
| GSE53622 | TANK | 10010 | 84655 | 0.4053 | 0.0000 | |
| GSE53624 | TANK | 10010 | 85692 | 0.1731 | 0.0044 | |
| GSE63941 | TANK | 10010 | 207616_s_at | -0.6018 | 0.2462 | |
| GSE77861 | TANK | 10010 | 207616_s_at | 0.4225 | 0.0621 | |
| GSE97050 | TANK | 10010 | A_23_P154306 | 0.3083 | 0.2467 | |
| SRP007169 | TANK | 10010 | RNAseq | 0.8353 | 0.0318 | |
| SRP008496 | TANK | 10010 | RNAseq | 0.5563 | 0.0423 | |
| SRP064894 | TANK | 10010 | RNAseq | 0.2499 | 0.2387 | |
| SRP133303 | TANK | 10010 | RNAseq | 0.3950 | 0.0144 | |
| SRP159526 | TANK | 10010 | RNAseq | 0.3449 | 0.3492 | |
| SRP193095 | TANK | 10010 | RNAseq | -0.0613 | 0.5882 | |
| SRP219564 | TANK | 10010 | RNAseq | -0.1798 | 0.5007 | |
| TCGA | TANK | 10010 | RNAseq | 0.0187 | 0.7158 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TANK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TANK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TANK | 10010 | 4 | 1 | 25 | |
| GSE20123 | TANK | 10010 | 4 | 1 | 25 | |
| GSE43470 | TANK | 10010 | 4 | 1 | 38 | |
| GSE46452 | TANK | 10010 | 1 | 4 | 54 | |
| GSE47630 | TANK | 10010 | 5 | 3 | 32 | |
| GSE54993 | TANK | 10010 | 0 | 5 | 65 | |
| GSE54994 | TANK | 10010 | 11 | 2 | 40 | |
| GSE60625 | TANK | 10010 | 0 | 3 | 8 | |
| GSE74703 | TANK | 10010 | 3 | 1 | 32 | |
| GSE74704 | TANK | 10010 | 3 | 0 | 17 | |
| TCGA | TANK | 10010 | 23 | 10 | 63 |
Total number of gains: 58; Total number of losses: 31; Total Number of normals: 399.
Somatic mutations of TANK:
Generating mutation plots.
Highly correlated genes for TANK:
Showing top 20/95 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TANK | OPN3 | 0.765491 | 4 | 0 | 4 |
| TANK | OSBPL11 | 0.764056 | 3 | 0 | 3 |
| TANK | SNAI2 | 0.749374 | 4 | 0 | 3 |
| TANK | LAMA3 | 0.747673 | 3 | 0 | 3 |
| TANK | METTL4 | 0.725073 | 4 | 0 | 4 |
| TANK | POLR3G | 0.70707 | 3 | 0 | 3 |
| TANK | GALNS | 0.70184 | 4 | 0 | 3 |
| TANK | ITGA6 | 0.687256 | 4 | 0 | 3 |
| TANK | EFNA4 | 0.685027 | 3 | 0 | 3 |
| TANK | ABHD10 | 0.677103 | 3 | 0 | 3 |
| TANK | RNF43 | 0.640127 | 4 | 0 | 4 |
| TANK | IL36G | 0.638947 | 3 | 0 | 3 |
| TANK | SUMO1 | 0.636739 | 5 | 0 | 3 |
| TANK | YEATS4 | 0.628135 | 4 | 0 | 3 |
| TANK | MPLKIP | 0.625454 | 3 | 0 | 3 |
| TANK | LINC00597 | 0.62 | 3 | 0 | 3 |
| TANK | MYO10 | 0.619836 | 4 | 0 | 3 |
| TANK | NPL | 0.618615 | 7 | 0 | 5 |
| TANK | ZBTB6 | 0.618197 | 5 | 0 | 4 |
| TANK | FAM91A1 | 0.618024 | 4 | 0 | 3 |
For details and further investigation, click here
