EGF

 

Full name: epidermal growth factor Alias Symbol: 
Type: protein-coding gene Cytoband: 4q25
Entrez ID: 1950 HGNC ID: HGNC:3229 Ensembl Gene: ENSG00000138798 OMIM ID: 131530
Drug and gene relationship at DGIdb

 

EGF involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa04540Gap junction
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of EGF:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 EGF 1950 206254_at 0.5015 0.3957
GSE20347 EGF 1950 206254_at 0.5186 0.0090
GSE23400 EGF 1950 206254_at 0.0698 0.0310
GSE26886 EGF 1950 206254_at 0.3948 0.0095
GSE29001 EGF 1950 206254_at 0.3720 0.1667
GSE38129 EGF 1950 206254_at 0.6996 0.0012
GSE45670 EGF 1950 206254_at 0.4737 0.0467
GSE53622 EGF 1950 9235 0.1739 0.3926
GSE53624 EGF 1950 9235 0.6576 0.0002
GSE63941 EGF 1950 206254_at 0.5348 0.6538
GSE77861 EGF 1950 206254_at 0.0725 0.5556
SRP007169 EGF 1950 RNAseq 2.3651 0.0175
SRP133303 EGF 1950 RNAseq 1.3799 0.0028
SRP159526 EGF 1950 RNAseq 2.7343 0.0000
SRP193095 EGF 1950 RNAseq 1.3352 0.0000
TCGA EGF 1950 RNAseq 1.6910 0.0002

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by EGF expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EGF:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EGF 1950 1 12 17
GSE20123 EGF 1950 1 12 17
GSE43470 EGF 1950 0 13 30
GSE46452 EGF 1950 1 36 22
GSE47630 EGF 1950 0 20 20
GSE54993 EGF 1950 9 0 61
GSE54994 EGF 1950 1 10 42
GSE60625 EGF 1950 0 3 8
GSE74703 EGF 1950 0 11 25
GSE74704 EGF 1950 0 6 14
TCGA EGF 1950 8 35 53

Total number of gains: 21; Total number of losses: 158; Total Number of normals: 309.  

 

Somatic mutations of EGF:

 

Generating mutation plots.

 

Highly correlated genes for EGF:

 

Showing top 20/91 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EGFTMEM1630.761714303
EGFZBED10.687496303
EGFFAM49A0.673091303
EGFATP2A30.659772303
EGFPCSK1N0.65119404
EGFBMF0.645544303
EGFCD2000.637198303
EGFMIEN10.628431303
EGFMED10.620479404
EGFHHEX0.615974404
EGFGSDMD0.609257303
EGFMCF2L-AS10.609199404
EGFARHGAP260.608758303
EGFSTRADA0.608204303
EGFJAKMIP20.607951605
EGFSPOCK10.607194303
EGFKLHL220.605473403
EGFANKRD100.599588403
EGFIQCE0.596681303
EGFPRAME0.593436604

For details and further investigation, click here