| Full name: hematopoietically expressed homeobox | Alias Symbol: HEX|HOX11L-PEN | ||
| Type: protein-coding gene | Cytoband: 10q23.33 | ||
| Entrez ID: 3087 | HGNC ID: HGNC:4901 | Ensembl Gene: ENSG00000152804 | OMIM ID: 604420 |
| Drug and gene relationship at DGIdb | |||
HHEX involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04950 | Maturity onset diabetes of the young |
Expression of HHEX:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HHEX | 3087 | 204689_at | 0.3998 | 0.5363 | |
| GSE20347 | HHEX | 3087 | 204689_at | 0.2263 | 0.0247 | |
| GSE23400 | HHEX | 3087 | 215933_s_at | 0.1933 | 0.0090 | |
| GSE26886 | HHEX | 3087 | 204689_at | 0.2049 | 0.5484 | |
| GSE29001 | HHEX | 3087 | 204689_at | 0.2744 | 0.1361 | |
| GSE38129 | HHEX | 3087 | 204689_at | 0.0937 | 0.6568 | |
| GSE45670 | HHEX | 3087 | 215933_s_at | -0.5860 | 0.2327 | |
| GSE53622 | HHEX | 3087 | 82257 | -0.3086 | 0.0631 | |
| GSE53624 | HHEX | 3087 | 82257 | -0.1387 | 0.4999 | |
| GSE63941 | HHEX | 3087 | 215933_s_at | -2.2410 | 0.0548 | |
| GSE77861 | HHEX | 3087 | 204689_at | 0.2279 | 0.0683 | |
| GSE97050 | HHEX | 3087 | A_23_P47034 | 0.3312 | 0.4228 | |
| SRP064894 | HHEX | 3087 | RNAseq | 0.4982 | 0.1029 | |
| SRP133303 | HHEX | 3087 | RNAseq | -0.7775 | 0.0159 | |
| SRP159526 | HHEX | 3087 | RNAseq | 1.1254 | 0.0890 | |
| SRP193095 | HHEX | 3087 | RNAseq | 0.6373 | 0.0120 | |
| SRP219564 | HHEX | 3087 | RNAseq | 0.4518 | 0.3275 | |
| TCGA | HHEX | 3087 | RNAseq | 0.0925 | 0.5718 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HHEX expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HHEX:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HHEX | 3087 | 2 | 7 | 21 | |
| GSE20123 | HHEX | 3087 | 2 | 6 | 22 | |
| GSE43470 | HHEX | 3087 | 0 | 8 | 35 | |
| GSE46452 | HHEX | 3087 | 0 | 11 | 48 | |
| GSE47630 | HHEX | 3087 | 2 | 14 | 24 | |
| GSE54993 | HHEX | 3087 | 7 | 0 | 63 | |
| GSE54994 | HHEX | 3087 | 1 | 10 | 42 | |
| GSE60625 | HHEX | 3087 | 0 | 0 | 11 | |
| GSE74703 | HHEX | 3087 | 0 | 6 | 30 | |
| GSE74704 | HHEX | 3087 | 0 | 4 | 16 | |
| TCGA | HHEX | 3087 | 7 | 26 | 63 |
Total number of gains: 21; Total number of losses: 92; Total Number of normals: 375.
Somatic mutations of HHEX:
Generating mutation plots.
Highly correlated genes for HHEX:
Showing top 20/753 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HHEX | TTL | 0.795924 | 3 | 0 | 3 |
| HHEX | DHX33 | 0.785963 | 3 | 0 | 3 |
| HHEX | GIMAP5 | 0.754827 | 3 | 0 | 3 |
| HHEX | YIF1A | 0.753016 | 3 | 0 | 3 |
| HHEX | DHFR | 0.744626 | 3 | 0 | 3 |
| HHEX | SUCNR1 | 0.738347 | 3 | 0 | 3 |
| HHEX | NCKAP1L | 0.737574 | 5 | 0 | 5 |
| HHEX | ATIC | 0.735612 | 3 | 0 | 3 |
| HHEX | RHBDD2 | 0.725923 | 4 | 0 | 4 |
| HHEX | SMARCAD1 | 0.724939 | 3 | 0 | 3 |
| HHEX | GLS | 0.723492 | 3 | 0 | 3 |
| HHEX | MAD2L1BP | 0.722786 | 3 | 0 | 3 |
| HHEX | AMMECR1L | 0.722276 | 3 | 0 | 3 |
| HHEX | SMCR8 | 0.709939 | 3 | 0 | 3 |
| HHEX | WIZ | 0.703711 | 3 | 0 | 3 |
| HHEX | PIK3AP1 | 0.701403 | 7 | 0 | 7 |
| HHEX | NDE1 | 0.700174 | 3 | 0 | 3 |
| HHEX | STRADA | 0.699974 | 5 | 0 | 4 |
| HHEX | SLC30A7 | 0.69701 | 3 | 0 | 3 |
| HHEX | PIM2 | 0.694695 | 4 | 0 | 3 |
For details and further investigation, click here
