Full name: epidermal growth factor receptor	Alias Symbol: ERBB1
Type: protein-coding gene	Cytoband: 7p11.2
Entrez ID: 1956	HGNC ID: HGNC:3236	Ensembl Gene: ENSG00000146648	OMIM ID: 131550
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 57/325 cell lines had fitness change in Project Score. This gene has been idenfitied as a common driver in this paper. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

---

 

EGFR involved pathways:

KEGG pathway	Description	View
hsa04010	MAPK signaling pathway	View
hsa04012	ErbB signaling pathway	View
hsa04014	Ras signaling pathway	View
hsa04015	Rap1 signaling pathway	View
hsa04020	Calcium signaling pathway	View
hsa04066	HIF-1 signaling pathway	View
hsa04068	FoxO signaling pathway	View
hsa04072	Phospholipase D signaling pathway	View
hsa04151	PI3K-Akt signaling pathway	View
hsa04510	Focal adhesion	View
hsa04520	Adherens junction	View
hsa04540	Gap junction	View
hsa04810	Regulation of actin cytoskeleton	View
hsa04912	GnRH signaling pathway	View
hsa04915	Estrogen signaling pathway	View
hsa04921	Oxytocin signaling pathway	View
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	View
hsa05160	Hepatitis C	View
hsa05200	Pathways in cancer	View
hsa05205	Proteoglycans in cancer	View
hsa05212	Pancreatic cancer	View
hsa05213	Endometrial cancer	View
hsa05214	Glioma	View
hsa05215	Prostate cancer	View
hsa05218	Melanoma	View
hsa05219	Bladder cancer	View
hsa05223	Non-small cell lung cancer	View
hsa05231	Choline metabolism in cancer	View

---

 

Expression of EGFR:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	EGFR	1956	201983_s_at	-0.0189	0.9813	Show
GSE20347	EGFR	1956	201983_s_at	0.6717	0.0241	Show
GSE23400	EGFR	1956	201983_s_at	0.7661	0.0001	Show
GSE26886	EGFR	1956	201983_s_at	1.3177	0.0001	Show
GSE29001	EGFR	1956	201983_s_at	0.9551	0.0866	Show
GSE38129	EGFR	1956	201983_s_at	0.5322	0.1130	Show
GSE45670	EGFR	1956	224999_at	0.0918	0.7140	Show
GSE53622	EGFR	1956	47004	0.7220	0.0000	Show
GSE53624	EGFR	1956	47004	0.7309	0.0000	Show
GSE63941	EGFR	1956	201983_s_at	2.9877	0.0010	Show
GSE77861	EGFR	1956	201983_s_at	0.9697	0.0637	Show
GSE97050	EGFR	1956	A_23_P215790	0.4537	0.2308	Show
SRP008496	EGFR	1956	RNAseq	3.4615	0.0001	Show
SRP064894	EGFR	1956	RNAseq	1.0714	0.0053	Show
SRP133303	EGFR	1956	RNAseq	0.3125	0.2705	Show
SRP159526	EGFR	1956	RNAseq	0.6850	0.0597	Show
SRP193095	EGFR	1956	RNAseq	1.0429	0.0002	Show
SRP219564	EGFR	1956	RNAseq	0.3769	0.4021	Show
TCGA	EGFR	1956	RNAseq	0.2376	0.0220	Show

Upregulated datasets: 5; Downregulated datasets: 0.  Download Data

---

 

Survival by EGFR expression:

 

---

Copy number change of EGFR:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	EGFR	1956	14	0	16	Show
GSE20123	EGFR	1956	12	0	18	Show
GSE43470	EGFR	1956	6	0	37	Show
GSE46452	EGFR	1956	13	0	46	Show
GSE47630	EGFR	1956	10	1	29	Show
GSE54993	EGFR	1956	0	11	59	Show
GSE54994	EGFR	1956	18	1	34	Show
GSE60625	EGFR	1956	0	0	11	Show
GSE74703	EGFR	1956	6	0	30	Show
GSE74704	EGFR	1956	6	0	14	Show
TCGA	EGFR	1956	57	5	34	Show

Total number of gains: 142; Total number of losses: 18; Total Number of normals: 328.  Download Data

---

 

Somatic mutations of EGFR:

 

---

 

Highly correlated genes for EGFR:

 

Showing top 20/583 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
EGFR	CHST3	0.725451	3	0	3
EGFR	LRRC8A	0.698022	3	0	3
EGFR	MB21D2	0.697188	3	0	3
EGFR	RILPL1	0.695636	3	0	3
EGFR	RRNAD1	0.691063	3	0	3
EGFR	ELOVL7	0.685698	4	0	4
EGFR	SLC41A1	0.682154	3	0	3
EGFR	ALKBH6	0.681871	3	0	3
EGFR	TMEM160	0.679864	3	0	3
EGFR	TMEM138	0.677279	4	0	4
EGFR	CHCHD6	0.676066	3	0	3
EGFR	DHX36	0.674033	5	0	4
EGFR	C12orf45	0.669599	3	0	3
EGFR	MRPS26	0.66652	3	0	3
EGFR	CYTH3	0.665647	4	0	3
EGFR	PHF14	0.664786	5	0	5
EGFR	CNTN1	0.660293	3	0	3
EGFR	HSPA13	0.656189	3	0	3
EGFR	CMTM4	0.655709	3	0	3
EGFR	TRMT2B	0.654338	4	0	4

For details and further investigation, click here