| Full name: leucine rich repeat containing 8 VRAC subunit A | Alias Symbol: KIAA1437|FLJ10337|SWELL1 | ||
| Type: protein-coding gene | Cytoband: 9q34.11 | ||
| Entrez ID: 56262 | HGNC ID: HGNC:19027 | Ensembl Gene: ENSG00000136802 | OMIM ID: 608360 |
| Drug and gene relationship at DGIdb | |||
Expression of LRRC8A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRC8A | 56262 | 224624_at | -0.1072 | 0.7557 | |
| GSE26886 | LRRC8A | 56262 | 224624_at | 0.1079 | 0.6668 | |
| GSE45670 | LRRC8A | 56262 | 224624_at | 0.3043 | 0.1244 | |
| GSE53622 | LRRC8A | 56262 | 25178 | -0.0091 | 0.9480 | |
| GSE53624 | LRRC8A | 56262 | 25178 | 0.3559 | 0.0000 | |
| GSE63941 | LRRC8A | 56262 | 224624_at | 0.2055 | 0.7237 | |
| GSE77861 | LRRC8A | 56262 | 224624_at | 0.5396 | 0.0073 | |
| GSE97050 | LRRC8A | 56262 | A_23_P250274 | 0.3679 | 0.2729 | |
| SRP007169 | LRRC8A | 56262 | RNAseq | 1.4875 | 0.0004 | |
| SRP008496 | LRRC8A | 56262 | RNAseq | 1.3204 | 0.0005 | |
| SRP064894 | LRRC8A | 56262 | RNAseq | -0.0389 | 0.8610 | |
| SRP133303 | LRRC8A | 56262 | RNAseq | 0.3932 | 0.1574 | |
| SRP159526 | LRRC8A | 56262 | RNAseq | 0.2579 | 0.6258 | |
| SRP193095 | LRRC8A | 56262 | RNAseq | 0.4735 | 0.0077 | |
| SRP219564 | LRRC8A | 56262 | RNAseq | -0.3507 | 0.3788 | |
| TCGA | LRRC8A | 56262 | RNAseq | 0.1660 | 0.0348 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LRRC8A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRRC8A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRC8A | 56262 | 6 | 9 | 15 | |
| GSE20123 | LRRC8A | 56262 | 6 | 9 | 15 | |
| GSE43470 | LRRC8A | 56262 | 5 | 8 | 30 | |
| GSE46452 | LRRC8A | 56262 | 6 | 13 | 40 | |
| GSE47630 | LRRC8A | 56262 | 3 | 16 | 21 | |
| GSE54993 | LRRC8A | 56262 | 3 | 3 | 64 | |
| GSE54994 | LRRC8A | 56262 | 11 | 8 | 34 | |
| GSE60625 | LRRC8A | 56262 | 0 | 0 | 11 | |
| GSE74703 | LRRC8A | 56262 | 5 | 6 | 25 | |
| GSE74704 | LRRC8A | 56262 | 3 | 7 | 10 | |
| TCGA | LRRC8A | 56262 | 27 | 24 | 45 |
Total number of gains: 75; Total number of losses: 103; Total Number of normals: 310.
Somatic mutations of LRRC8A:
Generating mutation plots.
Highly correlated genes for LRRC8A:
Showing top 20/313 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRC8A | BMP2 | 0.751186 | 3 | 0 | 3 |
| LRRC8A | C19orf54 | 0.743248 | 3 | 0 | 3 |
| LRRC8A | AFAP1L2 | 0.740775 | 3 | 0 | 3 |
| LRRC8A | RNF25 | 0.734812 | 3 | 0 | 3 |
| LRRC8A | DNMBP | 0.729155 | 3 | 0 | 3 |
| LRRC8A | DGUOK | 0.727648 | 3 | 0 | 3 |
| LRRC8A | LRP12 | 0.721867 | 3 | 0 | 3 |
| LRRC8A | LPCAT2 | 0.71999 | 3 | 0 | 3 |
| LRRC8A | ADAM17 | 0.712344 | 3 | 0 | 3 |
| LRRC8A | FBXL6 | 0.706211 | 3 | 0 | 3 |
| LRRC8A | SLC15A4 | 0.702192 | 3 | 0 | 3 |
| LRRC8A | PFN2 | 0.701 | 3 | 0 | 3 |
| LRRC8A | RTKN | 0.700478 | 4 | 0 | 3 |
| LRRC8A | RNASEH1 | 0.699958 | 3 | 0 | 3 |
| LRRC8A | CKAP5 | 0.699779 | 3 | 0 | 3 |
| LRRC8A | CABYR | 0.698549 | 3 | 0 | 3 |
| LRRC8A | EGFR | 0.698022 | 3 | 0 | 3 |
| LRRC8A | RFC3 | 0.696065 | 3 | 0 | 3 |
| LRRC8A | TMEM223 | 0.693957 | 3 | 0 | 3 |
| LRRC8A | PHF14 | 0.692267 | 3 | 0 | 3 |
For details and further investigation, click here
