| Full name: erythrocyte membrane protein band 4.1 like 3 | Alias Symbol: DAL1|KIAA0987|4.1B | ||
| Type: protein-coding gene | Cytoband: 18p11.31 | ||
| Entrez ID: 23136 | HGNC ID: HGNC:3380 | Ensembl Gene: ENSG00000082397 | OMIM ID: 605331 |
| Drug and gene relationship at DGIdb | |||
EPB41L3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of EPB41L3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPB41L3 | 23136 | 206710_s_at | -2.6661 | 0.0357 | |
| GSE20347 | EPB41L3 | 23136 | 211776_s_at | -2.9555 | 0.0000 | |
| GSE23400 | EPB41L3 | 23136 | 211776_s_at | -1.4016 | 0.0000 | |
| GSE26886 | EPB41L3 | 23136 | 206710_s_at | -5.2689 | 0.0000 | |
| GSE29001 | EPB41L3 | 23136 | 212681_at | -2.1912 | 0.0003 | |
| GSE38129 | EPB41L3 | 23136 | 211776_s_at | -2.5465 | 0.0000 | |
| GSE45670 | EPB41L3 | 23136 | 206710_s_at | -1.7574 | 0.0077 | |
| GSE53622 | EPB41L3 | 23136 | 10335 | -1.7355 | 0.0000 | |
| GSE53624 | EPB41L3 | 23136 | 10335 | -2.6738 | 0.0000 | |
| GSE63941 | EPB41L3 | 23136 | 211776_s_at | -2.3920 | 0.0508 | |
| GSE77861 | EPB41L3 | 23136 | 211776_s_at | -2.7442 | 0.0030 | |
| GSE97050 | EPB41L3 | 23136 | A_23_P4536 | -0.4006 | 0.5551 | |
| SRP007169 | EPB41L3 | 23136 | RNAseq | -1.4742 | 0.0071 | |
| SRP064894 | EPB41L3 | 23136 | RNAseq | -1.2841 | 0.0003 | |
| SRP133303 | EPB41L3 | 23136 | RNAseq | -1.4446 | 0.0000 | |
| SRP159526 | EPB41L3 | 23136 | RNAseq | -1.8655 | 0.0000 | |
| SRP193095 | EPB41L3 | 23136 | RNAseq | -2.1159 | 0.0000 | |
| SRP219564 | EPB41L3 | 23136 | RNAseq | -1.6089 | 0.0068 | |
| TCGA | EPB41L3 | 23136 | RNAseq | -0.1784 | 0.2296 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by EPB41L3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EPB41L3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPB41L3 | 23136 | 8 | 2 | 20 | |
| GSE20123 | EPB41L3 | 23136 | 8 | 2 | 20 | |
| GSE43470 | EPB41L3 | 23136 | 4 | 5 | 34 | |
| GSE46452 | EPB41L3 | 23136 | 3 | 21 | 35 | |
| GSE47630 | EPB41L3 | 23136 | 7 | 17 | 16 | |
| GSE54993 | EPB41L3 | 23136 | 6 | 3 | 61 | |
| GSE54994 | EPB41L3 | 23136 | 10 | 8 | 35 | |
| GSE60625 | EPB41L3 | 23136 | 0 | 4 | 7 | |
| GSE74703 | EPB41L3 | 23136 | 3 | 3 | 30 | |
| GSE74704 | EPB41L3 | 23136 | 6 | 1 | 13 | |
| TCGA | EPB41L3 | 23136 | 34 | 19 | 43 |
Total number of gains: 89; Total number of losses: 85; Total Number of normals: 314.
Somatic mutations of EPB41L3:
Generating mutation plots.
Highly correlated genes for EPB41L3:
Showing top 20/1750 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPB41L3 | SFTA2 | 0.882391 | 4 | 0 | 4 |
| EPB41L3 | GYS2 | 0.88062 | 10 | 0 | 10 |
| EPB41L3 | GDPD3 | 0.855519 | 10 | 0 | 10 |
| EPB41L3 | CYSRT1 | 0.854249 | 6 | 0 | 6 |
| EPB41L3 | RANBP9 | 0.849857 | 11 | 0 | 11 |
| EPB41L3 | HCG22 | 0.844409 | 6 | 0 | 6 |
| EPB41L3 | FAM214A | 0.842404 | 6 | 0 | 6 |
| EPB41L3 | FAM3D | 0.841514 | 6 | 0 | 6 |
| EPB41L3 | NAGK | 0.840478 | 11 | 0 | 11 |
| EPB41L3 | RMND5B | 0.838797 | 11 | 0 | 11 |
| EPB41L3 | SCNN1B | 0.838321 | 10 | 0 | 10 |
| EPB41L3 | C18orf25 | 0.835838 | 11 | 0 | 11 |
| EPB41L3 | EHD3 | 0.835085 | 12 | 0 | 11 |
| EPB41L3 | SLC16A6 | 0.834719 | 11 | 0 | 11 |
| EPB41L3 | SNORA68 | 0.834502 | 4 | 0 | 4 |
| EPB41L3 | UBL3 | 0.830311 | 11 | 0 | 10 |
| EPB41L3 | IL36A | 0.829782 | 10 | 0 | 10 |
| EPB41L3 | BLNK | 0.828947 | 11 | 0 | 11 |
| EPB41L3 | LRRFIP2 | 0.824675 | 11 | 0 | 11 |
| EPB41L3 | SPNS2 | 0.82237 | 5 | 0 | 5 |
For details and further investigation, click here
