| Full name: interleukin 36 alpha | Alias Symbol: FIL1|FIL1E|IL-1F6|IL1(EPSILON)|MGC129553|MGC129552 | ||
| Type: protein-coding gene | Cytoband: 2q14.1 | ||
| Entrez ID: 27179 | HGNC ID: HGNC:15562 | Ensembl Gene: ENSG00000136694 | OMIM ID: 605509 |
| Drug and gene relationship at DGIdb | |||
Expression of IL36A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL36A | 27179 | 221404_at | -2.0632 | 0.0981 | |
| GSE20347 | IL36A | 27179 | 221404_at | -1.5003 | 0.0000 | |
| GSE23400 | IL36A | 27179 | 221404_at | -2.3422 | 0.0000 | |
| GSE26886 | IL36A | 27179 | 221404_at | -4.8435 | 0.0000 | |
| GSE29001 | IL36A | 27179 | 221404_at | -2.0303 | 0.0001 | |
| GSE38129 | IL36A | 27179 | 221404_at | -1.5049 | 0.0000 | |
| GSE45670 | IL36A | 27179 | 221404_at | -1.4619 | 0.0124 | |
| GSE53622 | IL36A | 27179 | 95324 | -4.3001 | 0.0000 | |
| GSE53624 | IL36A | 27179 | 95324 | -4.4282 | 0.0000 | |
| GSE63941 | IL36A | 27179 | 221404_at | 0.1537 | 0.3680 | |
| GSE77861 | IL36A | 27179 | 221404_at | -1.4045 | 0.0109 | |
| GSE97050 | IL36A | 27179 | A_23_P348028 | -1.6206 | 0.0786 | |
| SRP007169 | IL36A | 27179 | RNAseq | -8.1245 | 0.0000 | |
| SRP008496 | IL36A | 27179 | RNAseq | -7.4146 | 0.0000 | |
| SRP064894 | IL36A | 27179 | RNAseq | -6.2883 | 0.0000 | |
| SRP133303 | IL36A | 27179 | RNAseq | -5.5519 | 0.0000 | |
| SRP159526 | IL36A | 27179 | RNAseq | -6.8399 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by IL36A expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of IL36A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL36A | 27179 | 6 | 2 | 22 | |
| GSE20123 | IL36A | 27179 | 6 | 2 | 22 | |
| GSE43470 | IL36A | 27179 | 3 | 1 | 39 | |
| GSE46452 | IL36A | 27179 | 1 | 4 | 54 | |
| GSE47630 | IL36A | 27179 | 7 | 0 | 33 | |
| GSE54993 | IL36A | 27179 | 0 | 6 | 64 | |
| GSE54994 | IL36A | 27179 | 10 | 0 | 43 | |
| GSE60625 | IL36A | 27179 | 0 | 3 | 8 | |
| GSE74703 | IL36A | 27179 | 3 | 1 | 32 | |
| GSE74704 | IL36A | 27179 | 3 | 2 | 15 | |
| TCGA | IL36A | 27179 | 31 | 6 | 59 |
Total number of gains: 70; Total number of losses: 27; Total Number of normals: 391.
Somatic mutations of IL36A:
Generating mutation plots.
Highly correlated genes for IL36A:
Showing top 20/1321 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL36A | NCCRP1 | 0.948861 | 3 | 0 | 3 |
| IL36A | PRSS27 | 0.913486 | 7 | 0 | 7 |
| IL36A | TMPRSS11A | 0.902195 | 3 | 0 | 3 |
| IL36A | GDPD3 | 0.897278 | 11 | 0 | 11 |
| IL36A | CYSRT1 | 0.891767 | 6 | 0 | 6 |
| IL36A | VSIG10L | 0.890159 | 7 | 0 | 7 |
| IL36A | TMPRSS11B | 0.887987 | 7 | 0 | 7 |
| IL36A | SLURP1 | 0.886993 | 11 | 0 | 11 |
| IL36A | EPS8L1 | 0.882852 | 11 | 0 | 11 |
| IL36A | SPINK7 | 0.881993 | 7 | 0 | 7 |
| IL36A | ECM1 | 0.881763 | 11 | 0 | 11 |
| IL36A | KRT78 | 0.876633 | 7 | 0 | 7 |
| IL36A | GYS2 | 0.876559 | 10 | 0 | 10 |
| IL36A | RAET1E | 0.875895 | 7 | 0 | 7 |
| IL36A | TGM3 | 0.875864 | 11 | 0 | 11 |
| IL36A | C18orf25 | 0.873439 | 10 | 0 | 10 |
| IL36A | ANXA9 | 0.873077 | 10 | 0 | 10 |
| IL36A | SCNN1B | 0.872326 | 11 | 0 | 11 |
| IL36A | MXD1 | 0.871746 | 11 | 0 | 11 |
| IL36A | UPK1A | 0.870862 | 11 | 0 | 11 |
For details and further investigation, click here
