| Full name: apoptosis inhibitor 5 | Alias Symbol: AAC-11|API5L1|AAC11 | ||
| Type: protein-coding gene | Cytoband: 11p12 | ||
| Entrez ID: 8539 | HGNC ID: HGNC:594 | Ensembl Gene: ENSG00000166181 | OMIM ID: 609774 |
| Drug and gene relationship at DGIdb | |||
Expression of API5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | API5 | 8539 | 201687_s_at | 0.1383 | 0.5590 | |
| GSE20347 | API5 | 8539 | 201687_s_at | -0.0261 | 0.8627 | |
| GSE23400 | API5 | 8539 | 201687_s_at | 0.2579 | 0.0003 | |
| GSE26886 | API5 | 8539 | 201687_s_at | -0.0052 | 0.9868 | |
| GSE29001 | API5 | 8539 | 201687_s_at | 0.0993 | 0.7955 | |
| GSE38129 | API5 | 8539 | 201687_s_at | -0.0436 | 0.6891 | |
| GSE45670 | API5 | 8539 | 201687_s_at | 0.1617 | 0.2761 | |
| GSE53622 | API5 | 8539 | 102559 | 0.2242 | 0.0001 | |
| GSE53624 | API5 | 8539 | 102559 | 0.1722 | 0.0113 | |
| GSE63941 | API5 | 8539 | 201687_s_at | 0.2789 | 0.4860 | |
| GSE77861 | API5 | 8539 | 201687_s_at | 0.1309 | 0.6817 | |
| GSE97050 | API5 | 8539 | A_23_P203255 | 0.2491 | 0.3122 | |
| SRP007169 | API5 | 8539 | RNAseq | 0.6748 | 0.1061 | |
| SRP008496 | API5 | 8539 | RNAseq | 0.8459 | 0.0022 | |
| SRP064894 | API5 | 8539 | RNAseq | -0.0543 | 0.6687 | |
| SRP133303 | API5 | 8539 | RNAseq | 0.4156 | 0.0814 | |
| SRP159526 | API5 | 8539 | RNAseq | -0.2223 | 0.2788 | |
| SRP193095 | API5 | 8539 | RNAseq | -0.2316 | 0.0108 | |
| SRP219564 | API5 | 8539 | RNAseq | 0.0203 | 0.9205 | |
| TCGA | API5 | 8539 | RNAseq | 0.0265 | 0.5413 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by API5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of API5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | API5 | 8539 | 1 | 7 | 22 | |
| GSE20123 | API5 | 8539 | 1 | 6 | 23 | |
| GSE43470 | API5 | 8539 | 3 | 5 | 35 | |
| GSE46452 | API5 | 8539 | 8 | 5 | 46 | |
| GSE47630 | API5 | 8539 | 3 | 9 | 28 | |
| GSE54993 | API5 | 8539 | 3 | 0 | 67 | |
| GSE54994 | API5 | 8539 | 2 | 10 | 41 | |
| GSE60625 | API5 | 8539 | 0 | 0 | 11 | |
| GSE74703 | API5 | 8539 | 2 | 3 | 31 | |
| GSE74704 | API5 | 8539 | 1 | 5 | 14 | |
| TCGA | API5 | 8539 | 13 | 20 | 63 |
Total number of gains: 37; Total number of losses: 70; Total Number of normals: 381.
Somatic mutations of API5:
Generating mutation plots.
Highly correlated genes for API5:
Showing top 20/560 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| API5 | RPP38 | 0.787248 | 3 | 0 | 3 |
| API5 | NFKB1 | 0.786832 | 3 | 0 | 3 |
| API5 | CDIPT | 0.747063 | 3 | 0 | 3 |
| API5 | RBMX | 0.743816 | 3 | 0 | 3 |
| API5 | SNUPN | 0.741376 | 3 | 0 | 3 |
| API5 | DNASE2 | 0.735277 | 3 | 0 | 3 |
| API5 | DDX23 | 0.734814 | 4 | 0 | 4 |
| API5 | RAD23A | 0.734652 | 3 | 0 | 3 |
| API5 | ZNF260 | 0.733751 | 4 | 0 | 3 |
| API5 | ZNF551 | 0.732644 | 3 | 0 | 3 |
| API5 | ATXN7L3B | 0.729879 | 5 | 0 | 4 |
| API5 | CCDC15 | 0.726626 | 3 | 0 | 3 |
| API5 | FAM118B | 0.721293 | 3 | 0 | 3 |
| API5 | CNOT7 | 0.720105 | 3 | 0 | 3 |
| API5 | SAE1 | 0.718756 | 3 | 0 | 3 |
| API5 | RPL19 | 0.713387 | 3 | 0 | 3 |
| API5 | CHCHD6 | 0.706268 | 3 | 0 | 3 |
| API5 | TUBA1B | 0.699997 | 4 | 0 | 4 |
| API5 | TBC1D5 | 0.699637 | 3 | 0 | 3 |
| API5 | DTYMK | 0.693 | 3 | 0 | 3 |
For details and further investigation, click here
