ERCC2

 

Full name: ERCC excision repair 2, TFIIH core complex helicase subunit Alias Symbol: MAG|EM9|MGC102762|MGC126218|MGC126219|TFIIH
Type: protein-coding gene Cytoband: 19q13.32
Entrez ID: 2068 HGNC ID: HGNC:3434 Ensembl Gene: ENSG00000104884 OMIM ID: 126340
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 260/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ERCC2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ERCC2 2068 235399_at 0.0171 0.9611
GSE20347 ERCC2 2068 213468_at 0.1204 0.0991
GSE23400 ERCC2 2068 213468_at 0.1053 0.0113
GSE26886 ERCC2 2068 235399_at 0.1703 0.2473
GSE29001 ERCC2 2068 213468_at 0.1094 0.4539
GSE38129 ERCC2 2068 213468_at 0.0105 0.9416
GSE45670 ERCC2 2068 235399_at 0.1898 0.0160
GSE53622 ERCC2 2068 77571 0.7415 0.0000
GSE53624 ERCC2 2068 77571 0.7534 0.0000
GSE63941 ERCC2 2068 235399_at -0.2029 0.3790
GSE77861 ERCC2 2068 235399_at -0.0911 0.4626
GSE97050 ERCC2 2068 A_24_P401990 0.4601 0.1450
SRP007169 ERCC2 2068 RNAseq 0.6339 0.1998
SRP008496 ERCC2 2068 RNAseq 0.7441 0.0771
SRP064894 ERCC2 2068 RNAseq 1.1075 0.0000
SRP133303 ERCC2 2068 RNAseq 0.4607 0.0024
SRP159526 ERCC2 2068 RNAseq 0.6127 0.0784
SRP193095 ERCC2 2068 RNAseq 0.3012 0.0184
SRP219564 ERCC2 2068 RNAseq -0.1111 0.7458
TCGA ERCC2 2068 RNAseq 0.0550 0.3859

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by ERCC2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ERCC2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ERCC2 2068 4 5 21
GSE20123 ERCC2 2068 4 4 22
GSE43470 ERCC2 2068 3 11 29
GSE46452 ERCC2 2068 45 1 13
GSE47630 ERCC2 2068 8 6 26
GSE54993 ERCC2 2068 17 4 49
GSE54994 ERCC2 2068 6 12 35
GSE60625 ERCC2 2068 9 0 2
GSE74703 ERCC2 2068 3 7 26
GSE74704 ERCC2 2068 4 2 14
TCGA ERCC2 2068 15 16 65

Total number of gains: 118; Total number of losses: 68; Total Number of normals: 302.  

 

Somatic mutations of ERCC2:

 

Generating mutation plots.

 

Highly correlated genes for ERCC2:

 

Showing top 20/430 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ERCC2MPND0.764347303
ERCC2TP53I130.752907303
ERCC2ZNF8370.75156303
ERCC2SLC19A10.740356303
ERCC2GLT8D10.738042303
ERCC2TAS2R430.731944303
ERCC2ZNF6890.725454303
ERCC2LEPR0.724097303
ERCC2FAM131B0.721941303
ERCC2UBE2M0.714062303
ERCC2C1orf1220.712324303
ERCC2SCNM10.71185303
ERCC2SIN3A0.7105303
ERCC2PDE7A0.709108303
ERCC2TIE10.707855303
ERCC2RNF310.701924303
ERCC2PLCB20.701723303
ERCC2SLC5A20.700974303
ERCC2C9orf160.699487303
ERCC2MUL10.698948303

For details and further investigation, click here