| Full name: tyrosine kinase with immunoglobulin like and EGF like domains 1 | Alias Symbol: JTK14 | ||
| Type: protein-coding gene | Cytoband: 1p34.2 | ||
| Entrez ID: 7075 | HGNC ID: HGNC:11809 | Ensembl Gene: ENSG00000066056 | OMIM ID: 600222 |
| Drug and gene relationship at DGIdb | |||
Expression of TIE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TIE1 | 7075 | 204468_s_at | 0.0536 | 0.9453 | |
| GSE20347 | TIE1 | 7075 | 204468_s_at | -0.0349 | 0.6708 | |
| GSE23400 | TIE1 | 7075 | 204468_s_at | 0.1643 | 0.0815 | |
| GSE26886 | TIE1 | 7075 | 204468_s_at | -0.1105 | 0.4286 | |
| GSE29001 | TIE1 | 7075 | 204468_s_at | 0.0849 | 0.7421 | |
| GSE38129 | TIE1 | 7075 | 204468_s_at | -0.1918 | 0.5971 | |
| GSE45670 | TIE1 | 7075 | 204468_s_at | -0.1921 | 0.4733 | |
| GSE53622 | TIE1 | 7075 | 16349 | -0.1644 | 0.2407 | |
| GSE53624 | TIE1 | 7075 | 16349 | 0.2812 | 0.0380 | |
| GSE63941 | TIE1 | 7075 | 204468_s_at | 0.0445 | 0.7650 | |
| GSE77861 | TIE1 | 7075 | 204468_s_at | 0.1726 | 0.4021 | |
| GSE97050 | TIE1 | 7075 | A_23_P126416 | 0.6437 | 0.1518 | |
| SRP007169 | TIE1 | 7075 | RNAseq | 1.6989 | 0.0018 | |
| SRP008496 | TIE1 | 7075 | RNAseq | 1.6668 | 0.0005 | |
| SRP064894 | TIE1 | 7075 | RNAseq | 0.8751 | 0.0069 | |
| SRP133303 | TIE1 | 7075 | RNAseq | -0.4440 | 0.1164 | |
| SRP159526 | TIE1 | 7075 | RNAseq | 0.1129 | 0.8066 | |
| SRP193095 | TIE1 | 7075 | RNAseq | 0.9816 | 0.0000 | |
| SRP219564 | TIE1 | 7075 | RNAseq | 0.2106 | 0.7102 | |
| TCGA | TIE1 | 7075 | RNAseq | -0.3248 | 0.0034 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TIE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TIE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TIE1 | 7075 | 4 | 3 | 23 | |
| GSE20123 | TIE1 | 7075 | 4 | 2 | 24 | |
| GSE43470 | TIE1 | 7075 | 7 | 2 | 34 | |
| GSE46452 | TIE1 | 7075 | 3 | 1 | 55 | |
| GSE47630 | TIE1 | 7075 | 9 | 2 | 29 | |
| GSE54993 | TIE1 | 7075 | 0 | 2 | 68 | |
| GSE54994 | TIE1 | 7075 | 13 | 2 | 38 | |
| GSE60625 | TIE1 | 7075 | 0 | 0 | 11 | |
| GSE74703 | TIE1 | 7075 | 6 | 1 | 29 | |
| GSE74704 | TIE1 | 7075 | 2 | 0 | 18 | |
| TCGA | TIE1 | 7075 | 13 | 16 | 67 |
Total number of gains: 61; Total number of losses: 31; Total Number of normals: 396.
Somatic mutations of TIE1:
Generating mutation plots.
Highly correlated genes for TIE1:
Showing top 20/717 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TIE1 | ECSCR | 0.782997 | 6 | 0 | 6 |
| TIE1 | PLEK | 0.75681 | 3 | 0 | 3 |
| TIE1 | ACVRL1 | 0.743241 | 7 | 0 | 7 |
| TIE1 | ENG | 0.742849 | 10 | 0 | 9 |
| TIE1 | C19orf38 | 0.734454 | 3 | 0 | 3 |
| TIE1 | SSH1 | 0.726907 | 4 | 0 | 4 |
| TIE1 | ADAM23 | 0.725994 | 3 | 0 | 3 |
| TIE1 | TM4SF18 | 0.721601 | 6 | 0 | 5 |
| TIE1 | HGF | 0.718075 | 3 | 0 | 3 |
| TIE1 | RHOJ | 0.716459 | 4 | 0 | 4 |
| TIE1 | SMPD1 | 0.716349 | 3 | 0 | 3 |
| TIE1 | PRKACA | 0.715334 | 3 | 0 | 3 |
| TIE1 | EFEMP1 | 0.715317 | 5 | 0 | 5 |
| TIE1 | CD93 | 0.712661 | 11 | 0 | 9 |
| TIE1 | SGTB | 0.710685 | 3 | 0 | 3 |
| TIE1 | ERCC2 | 0.707855 | 3 | 0 | 3 |
| TIE1 | CCDC102B | 0.707669 | 6 | 0 | 4 |
| TIE1 | PLEKHO2 | 0.707642 | 9 | 0 | 9 |
| TIE1 | STAB1 | 0.706051 | 8 | 0 | 7 |
| TIE1 | FAM171B | 0.70472 | 3 | 0 | 3 |
For details and further investigation, click here
