| Full name: leptin receptor | Alias Symbol: OBR|CD295 | ||
| Type: protein-coding gene | Cytoband: 1p31.3 | ||
| Entrez ID: 3953 | HGNC ID: HGNC:6554 | Ensembl Gene: ENSG00000116678 | OMIM ID: 601007 |
| Drug and gene relationship at DGIdb | |||
LEPR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04152 | AMPK signaling pathway | |
| hsa04630 | Jak-STAT signaling pathway | |
| hsa04920 | Adipocytokine signaling pathway | |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) |
Expression of LEPR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LEPR | 3953 | 1556919_at | -0.3371 | 0.1662 | |
| GSE26886 | LEPR | 3953 | 1556919_at | -0.0607 | 0.5073 | |
| GSE45670 | LEPR | 3953 | 1556919_at | -0.0921 | 0.4629 | |
| GSE53622 | LEPR | 3953 | 30042 | 2.1148 | 0.0000 | |
| GSE53624 | LEPR | 3953 | 30042 | 1.8121 | 0.0000 | |
| GSE63941 | LEPR | 3953 | 1556919_at | -0.0319 | 0.8467 | |
| GSE77861 | LEPR | 3953 | 1556919_at | -0.0075 | 0.9564 | |
| GSE97050 | LEPR | 3953 | A_33_P3339820 | 0.7843 | 0.0620 | |
| SRP007169 | LEPR | 3953 | RNAseq | -0.0417 | 0.9225 | |
| SRP008496 | LEPR | 3953 | RNAseq | 0.0874 | 0.8047 | |
| SRP064894 | LEPR | 3953 | RNAseq | -0.3045 | 0.3841 | |
| SRP133303 | LEPR | 3953 | RNAseq | -0.4997 | 0.0579 | |
| SRP159526 | LEPR | 3953 | RNAseq | -0.6775 | 0.1720 | |
| SRP193095 | LEPR | 3953 | RNAseq | 0.1967 | 0.2338 | |
| SRP219564 | LEPR | 3953 | RNAseq | -0.0357 | 0.9444 | |
| TCGA | LEPR | 3953 | RNAseq | -0.8813 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LEPR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LEPR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LEPR | 3953 | 2 | 6 | 22 | |
| GSE20123 | LEPR | 3953 | 2 | 5 | 23 | |
| GSE43470 | LEPR | 3953 | 4 | 4 | 35 | |
| GSE46452 | LEPR | 3953 | 0 | 1 | 58 | |
| GSE47630 | LEPR | 3953 | 8 | 5 | 27 | |
| GSE54993 | LEPR | 3953 | 0 | 0 | 70 | |
| GSE54994 | LEPR | 3953 | 6 | 4 | 43 | |
| GSE60625 | LEPR | 3953 | 0 | 0 | 11 | |
| GSE74703 | LEPR | 3953 | 3 | 3 | 30 | |
| GSE74704 | LEPR | 3953 | 1 | 2 | 17 | |
| TCGA | LEPR | 3953 | 8 | 20 | 68 |
Total number of gains: 34; Total number of losses: 50; Total Number of normals: 404.
Somatic mutations of LEPR:
Generating mutation plots.
Highly correlated genes for LEPR:
Showing top 20/128 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LEPR | FSCN1 | 0.808443 | 3 | 0 | 3 |
| LEPR | COL5A1 | 0.801171 | 3 | 0 | 3 |
| LEPR | COL1A1 | 0.792823 | 3 | 0 | 3 |
| LEPR | COL5A2 | 0.773452 | 3 | 0 | 3 |
| LEPR | THY1 | 0.759537 | 3 | 0 | 3 |
| LEPR | SLC19A1 | 0.754787 | 3 | 0 | 3 |
| LEPR | SPARC | 0.754291 | 3 | 0 | 3 |
| LEPR | ERCC2 | 0.724097 | 3 | 0 | 3 |
| LEPR | VCAN | 0.72152 | 3 | 0 | 3 |
| LEPR | CFLAR | 0.715427 | 4 | 0 | 3 |
| LEPR | COL3A1 | 0.71414 | 3 | 0 | 3 |
| LEPR | CDH11 | 0.708043 | 3 | 0 | 3 |
| LEPR | NXN | 0.697893 | 3 | 0 | 3 |
| LEPR | TNC | 0.69758 | 3 | 0 | 3 |
| LEPR | SH3PXD2B | 0.697515 | 3 | 0 | 3 |
| LEPR | FN1 | 0.69718 | 3 | 0 | 3 |
| LEPR | FNDC1 | 0.696719 | 3 | 0 | 3 |
| LEPR | LHX2 | 0.694599 | 3 | 0 | 3 |
| LEPR | SPON2 | 0.69287 | 3 | 0 | 3 |
| LEPR | BSG | 0.689375 | 3 | 0 | 3 |
For details and further investigation, click here
