| Full name: cullin 4A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 13q34 | ||
| Entrez ID: 8451 | HGNC ID: HGNC:2554 | Ensembl Gene: ENSG00000139842 | OMIM ID: 603137 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CUL4A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CUL4A | 8451 | 201424_s_at | 0.0791 | 0.8619 | |
| GSE20347 | CUL4A | 8451 | 201424_s_at | 0.4034 | 0.1765 | |
| GSE23400 | CUL4A | 8451 | 201423_s_at | 0.2026 | 0.0194 | |
| GSE26886 | CUL4A | 8451 | 201424_s_at | 0.1307 | 0.7073 | |
| GSE29001 | CUL4A | 8451 | 201424_s_at | 0.1456 | 0.5840 | |
| GSE38129 | CUL4A | 8451 | 201424_s_at | 0.4290 | 0.0405 | |
| GSE45670 | CUL4A | 8451 | 201424_s_at | 0.0635 | 0.7562 | |
| GSE53622 | CUL4A | 8451 | 21396 | 0.1905 | 0.0326 | |
| GSE53624 | CUL4A | 8451 | 21396 | 0.2312 | 0.0020 | |
| GSE63941 | CUL4A | 8451 | 201424_s_at | 0.0922 | 0.8748 | |
| GSE77861 | CUL4A | 8451 | 201424_s_at | 0.0614 | 0.8097 | |
| GSE97050 | CUL4A | 8451 | A_23_P151471 | 0.0739 | 0.7560 | |
| SRP007169 | CUL4A | 8451 | RNAseq | 1.3026 | 0.0112 | |
| SRP008496 | CUL4A | 8451 | RNAseq | 1.0081 | 0.0014 | |
| SRP064894 | CUL4A | 8451 | RNAseq | 0.1796 | 0.2933 | |
| SRP133303 | CUL4A | 8451 | RNAseq | -0.0041 | 0.9694 | |
| SRP159526 | CUL4A | 8451 | RNAseq | -0.1329 | 0.6156 | |
| SRP193095 | CUL4A | 8451 | RNAseq | 0.1570 | 0.1119 | |
| SRP219564 | CUL4A | 8451 | RNAseq | 0.4580 | 0.2087 | |
| TCGA | CUL4A | 8451 | RNAseq | -0.0325 | 0.5578 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CUL4A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CUL4A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CUL4A | 8451 | 7 | 12 | 11 | |
| GSE20123 | CUL4A | 8451 | 7 | 11 | 12 | |
| GSE43470 | CUL4A | 8451 | 4 | 15 | 24 | |
| GSE46452 | CUL4A | 8451 | 3 | 31 | 25 | |
| GSE47630 | CUL4A | 8451 | 3 | 26 | 11 | |
| GSE54993 | CUL4A | 8451 | 11 | 4 | 55 | |
| GSE54994 | CUL4A | 8451 | 10 | 9 | 34 | |
| GSE60625 | CUL4A | 8451 | 0 | 3 | 8 | |
| GSE74703 | CUL4A | 8451 | 3 | 11 | 22 | |
| GSE74704 | CUL4A | 8451 | 4 | 9 | 7 | |
| TCGA | CUL4A | 8451 | 20 | 31 | 45 |
Total number of gains: 72; Total number of losses: 162; Total Number of normals: 254.
Somatic mutations of CUL4A:
Generating mutation plots.
Highly correlated genes for CUL4A:
Showing top 20/40 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CUL4A | PHAX | 0.690429 | 3 | 0 | 3 |
| CUL4A | ZNF283 | 0.676381 | 4 | 0 | 3 |
| CUL4A | ZNF624 | 0.671559 | 4 | 0 | 3 |
| CUL4A | LYPD6 | 0.666605 | 3 | 0 | 3 |
| CUL4A | RWDD3 | 0.657704 | 5 | 0 | 4 |
| CUL4A | ARL8A | 0.655213 | 3 | 0 | 3 |
| CUL4A | TMCO3 | 0.622791 | 10 | 0 | 7 |
| CUL4A | MCF2L | 0.621486 | 6 | 0 | 5 |
| CUL4A | CCDC43 | 0.613526 | 4 | 0 | 3 |
| CUL4A | ZC3H8 | 0.612186 | 5 | 0 | 3 |
| CUL4A | ERCC5 | 0.608308 | 5 | 0 | 3 |
| CUL4A | GRTP1 | 0.604235 | 8 | 0 | 6 |
| CUL4A | MOB1B | 0.59826 | 4 | 0 | 3 |
| CUL4A | LIG4 | 0.595963 | 8 | 0 | 6 |
| CUL4A | RBM28 | 0.592428 | 5 | 0 | 4 |
| CUL4A | SIRT5 | 0.57528 | 5 | 0 | 3 |
| CUL4A | ABHD13 | 0.574605 | 5 | 0 | 3 |
| CUL4A | MPP3 | 0.572644 | 7 | 0 | 5 |
| CUL4A | GSAP | 0.57151 | 3 | 0 | 3 |
| CUL4A | SCAMP1-AS1 | 0.566433 | 3 | 0 | 3 |
For details and further investigation, click here
