| Full name: propionyl-CoA carboxylase subunit alpha | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 13q32.3 | ||
| Entrez ID: 5095 | HGNC ID: HGNC:8653 | Ensembl Gene: ENSG00000175198 | OMIM ID: 232000 |
| Drug and gene relationship at DGIdb | |||
Expression of PCCA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCCA | 5095 | 203860_at | -0.9853 | 0.0158 | |
| GSE20347 | PCCA | 5095 | 203860_at | -0.9072 | 0.0000 | |
| GSE23400 | PCCA | 5095 | 203860_at | -0.3068 | 0.0000 | |
| GSE26886 | PCCA | 5095 | 203860_at | -0.9987 | 0.0014 | |
| GSE29001 | PCCA | 5095 | 203860_at | -1.0597 | 0.0006 | |
| GSE38129 | PCCA | 5095 | 203860_at | -0.8779 | 0.0000 | |
| GSE45670 | PCCA | 5095 | 203860_at | -0.7346 | 0.0001 | |
| GSE53622 | PCCA | 5095 | 131143 | -0.9430 | 0.0000 | |
| GSE53624 | PCCA | 5095 | 131143 | -1.0232 | 0.0000 | |
| GSE63941 | PCCA | 5095 | 203860_at | 0.1136 | 0.8402 | |
| GSE77861 | PCCA | 5095 | 203860_at | -1.0031 | 0.0017 | |
| GSE97050 | PCCA | 5095 | A_23_P48358 | -0.4120 | 0.2641 | |
| SRP007169 | PCCA | 5095 | RNAseq | -0.4806 | 0.3424 | |
| SRP008496 | PCCA | 5095 | RNAseq | -0.6812 | 0.0396 | |
| SRP064894 | PCCA | 5095 | RNAseq | -0.7119 | 0.0000 | |
| SRP133303 | PCCA | 5095 | RNAseq | -0.7590 | 0.0001 | |
| SRP159526 | PCCA | 5095 | RNAseq | -1.1346 | 0.0017 | |
| SRP193095 | PCCA | 5095 | RNAseq | -0.8401 | 0.0000 | |
| SRP219564 | PCCA | 5095 | RNAseq | -0.7129 | 0.0788 | |
| TCGA | PCCA | 5095 | RNAseq | -0.6391 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by PCCA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCCA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCCA | 5095 | 3 | 10 | 17 | |
| GSE20123 | PCCA | 5095 | 3 | 9 | 18 | |
| GSE43470 | PCCA | 5095 | 4 | 12 | 27 | |
| GSE46452 | PCCA | 5095 | 0 | 32 | 27 | |
| GSE47630 | PCCA | 5095 | 3 | 26 | 11 | |
| GSE54993 | PCCA | 5095 | 11 | 4 | 55 | |
| GSE54994 | PCCA | 5095 | 6 | 10 | 37 | |
| GSE60625 | PCCA | 5095 | 0 | 3 | 8 | |
| GSE74703 | PCCA | 5095 | 3 | 10 | 23 | |
| GSE74704 | PCCA | 5095 | 1 | 9 | 10 | |
| TCGA | PCCA | 5095 | 18 | 34 | 44 |
Total number of gains: 52; Total number of losses: 159; Total Number of normals: 277.
Somatic mutations of PCCA:
Generating mutation plots.
Highly correlated genes for PCCA:
Showing top 20/729 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCCA | LMBRD1 | 0.725444 | 10 | 0 | 10 |
| PCCA | LINC00938 | 0.711797 | 3 | 0 | 3 |
| PCCA | GPR146 | 0.708713 | 3 | 0 | 3 |
| PCCA | AK9 | 0.704802 | 6 | 0 | 6 |
| PCCA | CCNG1 | 0.694592 | 9 | 0 | 8 |
| PCCA | FAM219B | 0.693329 | 4 | 0 | 4 |
| PCCA | GALNT12 | 0.692765 | 10 | 0 | 9 |
| PCCA | MPC1 | 0.69138 | 10 | 0 | 10 |
| PCCA | STAP2 | 0.688142 | 3 | 0 | 3 |
| PCCA | FAM189A2 | 0.687421 | 11 | 0 | 11 |
| PCCA | CLYBL | 0.686259 | 6 | 0 | 6 |
| PCCA | SSBP2 | 0.686162 | 10 | 0 | 9 |
| PCCA | RAB9B | 0.685578 | 4 | 0 | 4 |
| PCCA | EPHX2 | 0.685376 | 12 | 0 | 11 |
| PCCA | SHROOM3 | 0.68429 | 6 | 0 | 6 |
| PCCA | ADAMTS9-AS2 | 0.683006 | 4 | 0 | 4 |
| PCCA | EIF4E3 | 0.679006 | 6 | 0 | 6 |
| PCCA | NOSTRIN | 0.678967 | 4 | 0 | 4 |
| PCCA | CTTNBP2 | 0.67822 | 7 | 0 | 6 |
| PCCA | KIAA0232 | 0.67542 | 11 | 0 | 11 |
For details and further investigation, click here
