| Full name: myosin heavy chain 14 | Alias Symbol: FLJ13881|KIAA2034|MHC16|MYH17 | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 79784 | HGNC ID: HGNC:23212 | Ensembl Gene: ENSG00000105357 | OMIM ID: 608568 |
| Drug and gene relationship at DGIdb | |||
MYH14 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction | |
| hsa04810 | Regulation of actin cytoskeleton | |
| hsa05132 | Salmonella infection |
Expression of MYH14:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYH14 | 79784 | 219946_x_at | -0.6702 | 0.3165 | |
| GSE20347 | MYH14 | 79784 | 219946_x_at | -0.6094 | 0.0002 | |
| GSE23400 | MYH14 | 79784 | 219946_x_at | -0.4193 | 0.0003 | |
| GSE26886 | MYH14 | 79784 | 219946_x_at | -0.5019 | 0.0162 | |
| GSE29001 | MYH14 | 79784 | 219946_x_at | -1.0106 | 0.0020 | |
| GSE38129 | MYH14 | 79784 | 219946_x_at | -0.3758 | 0.0382 | |
| GSE45670 | MYH14 | 79784 | 219946_x_at | 0.0029 | 0.9901 | |
| GSE53622 | MYH14 | 79784 | 100090 | -0.1299 | 0.0569 | |
| GSE53624 | MYH14 | 79784 | 100090 | 0.0189 | 0.8531 | |
| GSE63941 | MYH14 | 79784 | 219946_x_at | 1.0625 | 0.0085 | |
| GSE77861 | MYH14 | 79784 | 219946_x_at | 0.0914 | 0.8187 | |
| GSE97050 | MYH14 | 79784 | A_24_P323545 | 0.0259 | 0.9148 | |
| SRP007169 | MYH14 | 79784 | RNAseq | 1.1808 | 0.0177 | |
| SRP008496 | MYH14 | 79784 | RNAseq | 0.9477 | 0.0158 | |
| SRP064894 | MYH14 | 79784 | RNAseq | -1.3054 | 0.0047 | |
| SRP133303 | MYH14 | 79784 | RNAseq | -1.2649 | 0.0000 | |
| SRP159526 | MYH14 | 79784 | RNAseq | -0.3797 | 0.4190 | |
| SRP193095 | MYH14 | 79784 | RNAseq | -0.6488 | 0.0191 | |
| SRP219564 | MYH14 | 79784 | RNAseq | -0.7502 | 0.2639 | |
| TCGA | MYH14 | 79784 | RNAseq | -0.1146 | 0.5276 |
Upregulated datasets: 2; Downregulated datasets: 3.
Survival by MYH14 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYH14:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYH14 | 79784 | 4 | 4 | 22 | |
| GSE20123 | MYH14 | 79784 | 4 | 3 | 23 | |
| GSE43470 | MYH14 | 79784 | 4 | 12 | 27 | |
| GSE46452 | MYH14 | 79784 | 45 | 1 | 13 | |
| GSE47630 | MYH14 | 79784 | 10 | 6 | 24 | |
| GSE54993 | MYH14 | 79784 | 17 | 4 | 49 | |
| GSE54994 | MYH14 | 79784 | 4 | 14 | 35 | |
| GSE60625 | MYH14 | 79784 | 9 | 0 | 2 | |
| GSE74703 | MYH14 | 79784 | 4 | 8 | 24 | |
| GSE74704 | MYH14 | 79784 | 4 | 1 | 15 | |
| TCGA | MYH14 | 79784 | 14 | 19 | 63 |
Total number of gains: 119; Total number of losses: 72; Total Number of normals: 297.
Somatic mutations of MYH14:
Generating mutation plots.
Highly correlated genes for MYH14:
Showing top 20/678 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYH14 | KLRG2 | 0.76664 | 3 | 0 | 3 |
| MYH14 | ST8SIA3 | 0.752599 | 3 | 0 | 3 |
| MYH14 | LRRIQ3 | 0.748514 | 3 | 0 | 3 |
| MYH14 | ANKRD33B | 0.745777 | 3 | 0 | 3 |
| MYH14 | KCNT1 | 0.743792 | 3 | 0 | 3 |
| MYH14 | CABP4 | 0.741336 | 3 | 0 | 3 |
| MYH14 | OR1J4 | 0.738647 | 3 | 0 | 3 |
| MYH14 | NXPH3 | 0.736368 | 3 | 0 | 3 |
| MYH14 | HSD3B1 | 0.734975 | 3 | 0 | 3 |
| MYH14 | CACNG4 | 0.726176 | 4 | 0 | 3 |
| MYH14 | RNF157 | 0.717568 | 3 | 0 | 3 |
| MYH14 | PNPLA2 | 0.701778 | 4 | 0 | 3 |
| MYH14 | RHBDD3 | 0.700612 | 3 | 0 | 3 |
| MYH14 | AQP4 | 0.699144 | 3 | 0 | 3 |
| MYH14 | C11orf86 | 0.691524 | 3 | 0 | 3 |
| MYH14 | SOX6 | 0.690529 | 3 | 0 | 3 |
| MYH14 | NOXA1 | 0.688023 | 6 | 0 | 6 |
| MYH14 | MAP3K9 | 0.682472 | 8 | 0 | 7 |
| MYH14 | TOR2A | 0.682318 | 3 | 0 | 3 |
| MYH14 | ZNF692 | 0.679855 | 3 | 0 | 3 |
For details and further investigation, click here
