| Full name: ERCC excision repair 6 like 2 | Alias Symbol: FLJ37706|RAD26L | ||
| Type: protein-coding gene | Cytoband: 9q22.32 | ||
| Entrez ID: 375748 | HGNC ID: HGNC:26922 | Ensembl Gene: ENSG00000182150 | OMIM ID: 615667 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ERCC6L2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ERCC6L2 | 375748 | 229710_at | -0.3700 | 0.2422 | |
| GSE26886 | ERCC6L2 | 375748 | 229710_at | 0.5302 | 0.0773 | |
| GSE45670 | ERCC6L2 | 375748 | 229710_at | -0.2880 | 0.1789 | |
| GSE53622 | ERCC6L2 | 375748 | 120112 | -0.1500 | 0.0738 | |
| GSE53624 | ERCC6L2 | 375748 | 120112 | -0.0282 | 0.6924 | |
| GSE63941 | ERCC6L2 | 375748 | 229710_at | 0.1465 | 0.8349 | |
| GSE77861 | ERCC6L2 | 375748 | 229710_at | 0.1944 | 0.1829 | |
| SRP007169 | ERCC6L2 | 375748 | RNAseq | 0.9163 | 0.0240 | |
| SRP008496 | ERCC6L2 | 375748 | RNAseq | 1.2389 | 0.0000 | |
| SRP064894 | ERCC6L2 | 375748 | RNAseq | 0.0041 | 0.9760 | |
| SRP133303 | ERCC6L2 | 375748 | RNAseq | -0.0714 | 0.4246 | |
| SRP159526 | ERCC6L2 | 375748 | RNAseq | -0.1699 | 0.4709 | |
| SRP193095 | ERCC6L2 | 375748 | RNAseq | -0.0780 | 0.4423 | |
| SRP219564 | ERCC6L2 | 375748 | RNAseq | -0.2053 | 0.5832 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ERCC6L2 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of ERCC6L2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ERCC6L2 | 375748 | 6 | 7 | 17 | |
| GSE20123 | ERCC6L2 | 375748 | 6 | 7 | 17 | |
| GSE43470 | ERCC6L2 | 375748 | 6 | 3 | 34 | |
| GSE46452 | ERCC6L2 | 375748 | 6 | 14 | 39 | |
| GSE47630 | ERCC6L2 | 375748 | 1 | 17 | 22 | |
| GSE54993 | ERCC6L2 | 375748 | 4 | 2 | 64 | |
| GSE54994 | ERCC6L2 | 375748 | 8 | 11 | 34 | |
| GSE60625 | ERCC6L2 | 375748 | 0 | 0 | 11 | |
| GSE74703 | ERCC6L2 | 375748 | 5 | 3 | 28 | |
| GSE74704 | ERCC6L2 | 375748 | 3 | 5 | 12 | |
| TCGA | ERCC6L2 | 375748 | 24 | 23 | 49 |
Total number of gains: 69; Total number of losses: 92; Total Number of normals: 327.
Somatic mutations of ERCC6L2:
Generating mutation plots.
Highly correlated genes for ERCC6L2:
Showing top 20/158 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ERCC6L2 | ZDHHC17 | 0.697825 | 5 | 0 | 5 |
| ERCC6L2 | A2M-AS1 | 0.679201 | 3 | 0 | 3 |
| ERCC6L2 | ZBTB26 | 0.677914 | 5 | 0 | 4 |
| ERCC6L2 | EPB41L2 | 0.674014 | 4 | 0 | 4 |
| ERCC6L2 | VPS13C | 0.660348 | 3 | 0 | 3 |
| ERCC6L2 | PKD2 | 0.660194 | 5 | 0 | 5 |
| ERCC6L2 | GNAZ | 0.660039 | 4 | 0 | 4 |
| ERCC6L2 | HNRNPA0 | 0.659083 | 3 | 0 | 3 |
| ERCC6L2 | VEZF1 | 0.65875 | 5 | 0 | 4 |
| ERCC6L2 | GABPB2 | 0.652913 | 3 | 0 | 3 |
| ERCC6L2 | LPP | 0.649671 | 5 | 0 | 4 |
| ERCC6L2 | ATRX | 0.640442 | 4 | 0 | 3 |
| ERCC6L2 | MEIS2 | 0.64025 | 3 | 0 | 3 |
| ERCC6L2 | MICU3 | 0.639991 | 4 | 0 | 4 |
| ERCC6L2 | PLCB4 | 0.635321 | 5 | 0 | 5 |
| ERCC6L2 | PSIP1 | 0.633177 | 5 | 0 | 3 |
| ERCC6L2 | ZNF512 | 0.633139 | 5 | 0 | 3 |
| ERCC6L2 | EPS8 | 0.630729 | 5 | 0 | 4 |
| ERCC6L2 | MDM1 | 0.629803 | 4 | 0 | 3 |
| ERCC6L2 | TGOLN2 | 0.626772 | 5 | 0 | 4 |
For details and further investigation, click here
