Full name: ATRX chromatin remodeler	Alias Symbol: XH2|XNP
Type: protein-coding gene	Cytoband: Xq21.1
Entrez ID: 546	HGNC ID: HGNC:886	Ensembl Gene: ENSG00000085224	OMIM ID: 300032
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 9/325 cell lines had fitness change in Project Score. This gene has been idenfitied as a common driver in this paper. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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Expression of ATRX:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	ATRX	546	208861_s_at	-0.2068	0.5391	Show
GSE20347	ATRX	546	208861_s_at	0.1094	0.6109	Show
GSE23400	ATRX	546	208861_s_at	0.1729	0.0494	Show
GSE26886	ATRX	546	208861_s_at	0.3794	0.0872	Show
GSE29001	ATRX	546	208861_s_at	0.2120	0.3336	Show
GSE38129	ATRX	546	208861_s_at	-0.0504	0.7656	Show
GSE45670	ATRX	546	208859_s_at	0.3245	0.1723	Show
GSE53622	ATRX	546	12402	-0.1931	0.0028	Show
GSE53624	ATRX	546	12402	-0.0725	0.1449	Show
GSE63941	ATRX	546	208861_s_at	-1.6799	0.0080	Show
GSE77861	ATRX	546	208861_s_at	0.3636	0.2319	Show
GSE97050	ATRX	546	A_33_P3319943	-0.5445	0.1239	Show
SRP007169	ATRX	546	RNAseq	0.7906	0.0674	Show
SRP008496	ATRX	546	RNAseq	1.0228	0.0012	Show
SRP064894	ATRX	546	RNAseq	-0.0853	0.6868	Show
SRP133303	ATRX	546	RNAseq	0.2431	0.1160	Show
SRP159526	ATRX	546	RNAseq	-0.1250	0.4732	Show
SRP193095	ATRX	546	RNAseq	0.1351	0.1784	Show
SRP219564	ATRX	546	RNAseq	-0.1412	0.7022	Show
TCGA	ATRX	546	RNAseq	-0.1751	0.0001	Show

Upregulated datasets: 1; Downregulated datasets: 1.  Download Data

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Survival by ATRX expression:

 

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Copy number change of ATRX:

 

No record found for this gene.

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Somatic mutations of ATRX:

 

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Highly correlated genes for ATRX:

 

Showing top 20/577 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
ATRX	CNST	0.760204	3	0	3
ATRX	ZFAND5	0.718962	3	0	3
ATRX	LARP4	0.710977	3	0	3
ATRX	ZNF260	0.70797	3	0	3
ATRX	COMMD6	0.706845	4	0	3
ATRX	PLIN4	0.705316	3	0	3
ATRX	FNIP2	0.70054	3	0	3
ATRX	PCMTD1	0.698149	3	0	3
ATRX	LSM14A	0.695046	3	0	3
ATRX	CCDC112	0.695042	3	0	3
ATRX	MRVI1	0.694805	4	0	4
ATRX	PNPLA8	0.692178	3	0	3
ATRX	C5orf24	0.685201	4	0	4
ATRX	C17orf80	0.67867	3	0	3
ATRX	PPIG	0.675393	4	0	3
ATRX	DOCK7	0.675139	4	0	3
ATRX	TAOK1	0.671327	4	0	4
ATRX	RPAP2	0.667283	3	0	3
ATRX	CTSF	0.667096	4	0	3
ATRX	FAM98B	0.664623	3	0	3

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