| Full name: cell division cycle 37 | Alias Symbol: P50CDC37 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 11140 | HGNC ID: HGNC:1735 | Ensembl Gene: ENSG00000105401 | OMIM ID: 605065 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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CDC37 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway |
Expression of CDC37:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDC37 | 11140 | 209953_s_at | 0.2841 | 0.3687 | |
| GSE20347 | CDC37 | 11140 | 209953_s_at | 0.0418 | 0.8085 | |
| GSE23400 | CDC37 | 11140 | 209953_s_at | 0.2628 | 0.0001 | |
| GSE26886 | CDC37 | 11140 | 209953_s_at | -0.3854 | 0.0399 | |
| GSE29001 | CDC37 | 11140 | 209953_s_at | 0.2299 | 0.6986 | |
| GSE38129 | CDC37 | 11140 | 209953_s_at | 0.1514 | 0.1756 | |
| GSE45670 | CDC37 | 11140 | 209953_s_at | 0.2117 | 0.2221 | |
| GSE53622 | CDC37 | 11140 | 23364 | -0.0716 | 0.1799 | |
| GSE53624 | CDC37 | 11140 | 23364 | 0.0387 | 0.5669 | |
| GSE63941 | CDC37 | 11140 | 209953_s_at | 0.9333 | 0.0124 | |
| GSE77861 | CDC37 | 11140 | 209953_s_at | 0.4372 | 0.0701 | |
| GSE97050 | CDC37 | 11140 | A_23_P130531 | 0.0698 | 0.7401 | |
| SRP007169 | CDC37 | 11140 | RNAseq | 0.7735 | 0.1892 | |
| SRP064894 | CDC37 | 11140 | RNAseq | 0.3720 | 0.0511 | |
| SRP133303 | CDC37 | 11140 | RNAseq | 0.0661 | 0.6245 | |
| SRP159526 | CDC37 | 11140 | RNAseq | -0.1318 | 0.4705 | |
| SRP193095 | CDC37 | 11140 | RNAseq | 0.1649 | 0.1717 | |
| SRP219564 | CDC37 | 11140 | RNAseq | 0.2695 | 0.3779 | |
| TCGA | CDC37 | 11140 | RNAseq | 0.0757 | 0.0878 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CDC37 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDC37:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDC37 | 11140 | 4 | 3 | 23 | |
| GSE20123 | CDC37 | 11140 | 3 | 1 | 26 | |
| GSE43470 | CDC37 | 11140 | 3 | 6 | 34 | |
| GSE46452 | CDC37 | 11140 | 47 | 1 | 11 | |
| GSE47630 | CDC37 | 11140 | 4 | 7 | 29 | |
| GSE54993 | CDC37 | 11140 | 16 | 3 | 51 | |
| GSE54994 | CDC37 | 11140 | 7 | 13 | 33 | |
| GSE60625 | CDC37 | 11140 | 9 | 0 | 2 | |
| GSE74703 | CDC37 | 11140 | 3 | 4 | 29 | |
| GSE74704 | CDC37 | 11140 | 0 | 1 | 19 | |
| TCGA | CDC37 | 11140 | 14 | 15 | 67 |
Total number of gains: 110; Total number of losses: 54; Total Number of normals: 324.
Somatic mutations of CDC37:
Generating mutation plots.
Highly correlated genes for CDC37:
Showing top 20/751 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDC37 | ESCO1 | 0.845777 | 3 | 0 | 3 |
| CDC37 | NSD1 | 0.839675 | 3 | 0 | 3 |
| CDC37 | EXOC6 | 0.803765 | 3 | 0 | 3 |
| CDC37 | C1orf122 | 0.798477 | 3 | 0 | 3 |
| CDC37 | RUNDC1 | 0.789812 | 3 | 0 | 3 |
| CDC37 | TRIAP1 | 0.775153 | 3 | 0 | 3 |
| CDC37 | TSEN15 | 0.767818 | 3 | 0 | 3 |
| CDC37 | LARP4 | 0.759273 | 3 | 0 | 3 |
| CDC37 | KLHDC3 | 0.756184 | 3 | 0 | 3 |
| CDC37 | ACO2 | 0.751838 | 3 | 0 | 3 |
| CDC37 | MRPL38 | 0.747936 | 5 | 0 | 5 |
| CDC37 | NR2F6 | 0.747243 | 3 | 0 | 3 |
| CDC37 | DUS3L | 0.739465 | 4 | 0 | 3 |
| CDC37 | OTUD7B | 0.733322 | 3 | 0 | 3 |
| CDC37 | CDC27 | 0.730546 | 3 | 0 | 3 |
| CDC37 | DAG1 | 0.729055 | 3 | 0 | 3 |
| CDC37 | WDR5 | 0.725726 | 4 | 0 | 4 |
| CDC37 | RPS19BP1 | 0.725628 | 4 | 0 | 4 |
| CDC37 | CSTF2T | 0.724019 | 4 | 0 | 3 |
| CDC37 | MPND | 0.723945 | 3 | 0 | 3 |
For details and further investigation, click here
