| Full name: left-right determination factor 1 | Alias Symbol: LEFTYB | ||
| Type: protein-coding gene | Cytoband: 1q42.12 | ||
| Entrez ID: 10637 | HGNC ID: HGNC:6552 | Ensembl Gene: ENSG00000243709 | OMIM ID: 603037 |
| Drug and gene relationship at DGIdb | |||
LEFTY1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway |
Expression of LEFTY1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LEFTY1 | 10637 | 206268_at | 0.0156 | 0.9714 | |
| GSE20347 | LEFTY1 | 10637 | 206268_at | 0.0111 | 0.8950 | |
| GSE23400 | LEFTY1 | 10637 | 206268_at | -0.1790 | 0.0000 | |
| GSE26886 | LEFTY1 | 10637 | 206268_at | 0.7797 | 0.0007 | |
| GSE29001 | LEFTY1 | 10637 | 206268_at | -0.1456 | 0.3338 | |
| GSE38129 | LEFTY1 | 10637 | 206268_at | -0.0055 | 0.9528 | |
| GSE45670 | LEFTY1 | 10637 | 206268_at | 0.1185 | 0.3983 | |
| GSE53622 | LEFTY1 | 10637 | 91657 | 0.2501 | 0.1004 | |
| GSE53624 | LEFTY1 | 10637 | 91657 | 0.5370 | 0.0016 | |
| GSE63941 | LEFTY1 | 10637 | 206268_at | 0.0531 | 0.7501 | |
| GSE77861 | LEFTY1 | 10637 | 206268_at | -0.1307 | 0.2306 | |
| TCGA | LEFTY1 | 10637 | RNAseq | -0.1434 | 0.6809 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LEFTY1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LEFTY1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LEFTY1 | 10637 | 11 | 0 | 19 | |
| GSE20123 | LEFTY1 | 10637 | 11 | 0 | 19 | |
| GSE43470 | LEFTY1 | 10637 | 7 | 1 | 35 | |
| GSE46452 | LEFTY1 | 10637 | 3 | 1 | 55 | |
| GSE47630 | LEFTY1 | 10637 | 15 | 0 | 25 | |
| GSE54993 | LEFTY1 | 10637 | 0 | 6 | 64 | |
| GSE54994 | LEFTY1 | 10637 | 16 | 0 | 37 | |
| GSE60625 | LEFTY1 | 10637 | 0 | 0 | 11 | |
| GSE74703 | LEFTY1 | 10637 | 7 | 1 | 28 | |
| GSE74704 | LEFTY1 | 10637 | 5 | 0 | 15 | |
| TCGA | LEFTY1 | 10637 | 46 | 3 | 47 |
Total number of gains: 121; Total number of losses: 12; Total Number of normals: 355.
Somatic mutations of LEFTY1:
Generating mutation plots.
Highly correlated genes for LEFTY1:
Showing top 20/373 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LEFTY1 | ANO3 | 0.715071 | 4 | 0 | 4 |
| LEFTY1 | OVGP1 | 0.712626 | 3 | 0 | 3 |
| LEFTY1 | SLC13A3 | 0.705983 | 5 | 0 | 5 |
| LEFTY1 | GRID2 | 0.692842 | 3 | 0 | 3 |
| LEFTY1 | SCG3 | 0.69002 | 3 | 0 | 3 |
| LEFTY1 | C6 | 0.685916 | 3 | 0 | 3 |
| LEFTY1 | FGF6 | 0.679513 | 3 | 0 | 3 |
| LEFTY1 | BFSP2 | 0.676609 | 3 | 0 | 3 |
| LEFTY1 | PRAMEF12 | 0.675983 | 4 | 0 | 3 |
| LEFTY1 | MBL2 | 0.675618 | 3 | 0 | 3 |
| LEFTY1 | GCM1 | 0.670425 | 4 | 0 | 3 |
| LEFTY1 | ZNF580 | 0.66953 | 3 | 0 | 3 |
| LEFTY1 | PSG7 | 0.669455 | 3 | 0 | 3 |
| LEFTY1 | CAMK2B | 0.664209 | 5 | 0 | 5 |
| LEFTY1 | ZNF205-AS1 | 0.661182 | 4 | 0 | 3 |
| LEFTY1 | C8orf34 | 0.660018 | 3 | 0 | 3 |
| LEFTY1 | SIRT3 | 0.659862 | 4 | 0 | 4 |
| LEFTY1 | COX6A2 | 0.654211 | 4 | 0 | 3 |
| LEFTY1 | MUC5AC | 0.653944 | 4 | 0 | 3 |
| LEFTY1 | G6PC | 0.653841 | 3 | 0 | 3 |
For details and further investigation, click here
