| Full name: extended synaptotagmin 1 | Alias Symbol: MBC2|KIAA0747 | ||
| Type: protein-coding gene | Cytoband: 12q13.2 | ||
| Entrez ID: 23344 | HGNC ID: HGNC:29534 | Ensembl Gene: ENSG00000139641 | OMIM ID: 616670 |
| Drug and gene relationship at DGIdb | |||
Expression of ESYT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ESYT1 | 23344 | 208858_s_at | 0.3029 | 0.5840 | |
| GSE20347 | ESYT1 | 23344 | 208858_s_at | 0.2485 | 0.0430 | |
| GSE23400 | ESYT1 | 23344 | 208858_s_at | 0.2367 | 0.0124 | |
| GSE26886 | ESYT1 | 23344 | 208858_s_at | 0.2265 | 0.2597 | |
| GSE29001 | ESYT1 | 23344 | 208858_s_at | 0.3326 | 0.1541 | |
| GSE38129 | ESYT1 | 23344 | 208858_s_at | 0.0581 | 0.7584 | |
| GSE45670 | ESYT1 | 23344 | 208858_s_at | 0.2400 | 0.1104 | |
| GSE53622 | ESYT1 | 23344 | 40385 | 0.3133 | 0.0002 | |
| GSE53624 | ESYT1 | 23344 | 40385 | 0.4435 | 0.0000 | |
| GSE63941 | ESYT1 | 23344 | 208858_s_at | -0.3767 | 0.3581 | |
| GSE77861 | ESYT1 | 23344 | 208858_s_at | 0.3468 | 0.1273 | |
| GSE97050 | ESYT1 | 23344 | A_23_P150852 | -0.1025 | 0.7732 | |
| SRP007169 | ESYT1 | 23344 | RNAseq | 1.0295 | 0.0015 | |
| SRP008496 | ESYT1 | 23344 | RNAseq | 0.7161 | 0.0005 | |
| SRP064894 | ESYT1 | 23344 | RNAseq | 0.7296 | 0.0000 | |
| SRP133303 | ESYT1 | 23344 | RNAseq | 0.3801 | 0.0067 | |
| SRP159526 | ESYT1 | 23344 | RNAseq | 0.1469 | 0.5149 | |
| SRP193095 | ESYT1 | 23344 | RNAseq | 0.6506 | 0.0000 | |
| SRP219564 | ESYT1 | 23344 | RNAseq | 0.0569 | 0.9154 | |
| TCGA | ESYT1 | 23344 | RNAseq | 0.0573 | 0.2732 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ESYT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ESYT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ESYT1 | 23344 | 7 | 2 | 21 | |
| GSE20123 | ESYT1 | 23344 | 7 | 1 | 22 | |
| GSE43470 | ESYT1 | 23344 | 4 | 0 | 39 | |
| GSE46452 | ESYT1 | 23344 | 8 | 1 | 50 | |
| GSE47630 | ESYT1 | 23344 | 10 | 2 | 28 | |
| GSE54993 | ESYT1 | 23344 | 0 | 5 | 65 | |
| GSE54994 | ESYT1 | 23344 | 4 | 1 | 48 | |
| GSE60625 | ESYT1 | 23344 | 0 | 0 | 11 | |
| GSE74703 | ESYT1 | 23344 | 4 | 0 | 32 | |
| GSE74704 | ESYT1 | 23344 | 4 | 1 | 15 | |
| TCGA | ESYT1 | 23344 | 15 | 10 | 71 |
Total number of gains: 63; Total number of losses: 23; Total Number of normals: 402.
Somatic mutations of ESYT1:
Generating mutation plots.
Highly correlated genes for ESYT1:
Showing top 20/958 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ESYT1 | USP37 | 0.74185 | 3 | 0 | 3 |
| ESYT1 | DDX20 | 0.740815 | 3 | 0 | 3 |
| ESYT1 | WDR35 | 0.73461 | 3 | 0 | 3 |
| ESYT1 | ZNF251 | 0.73181 | 3 | 0 | 3 |
| ESYT1 | NDUFA12 | 0.729547 | 3 | 0 | 3 |
| ESYT1 | INO80E | 0.723022 | 3 | 0 | 3 |
| ESYT1 | DAPK3 | 0.721766 | 3 | 0 | 3 |
| ESYT1 | RAB34 | 0.715452 | 3 | 0 | 3 |
| ESYT1 | PDK3 | 0.714897 | 3 | 0 | 3 |
| ESYT1 | ZNF317 | 0.700787 | 4 | 0 | 4 |
| ESYT1 | FAM13A | 0.695308 | 4 | 0 | 4 |
| ESYT1 | SLC37A3 | 0.694888 | 3 | 0 | 3 |
| ESYT1 | DTX3 | 0.692506 | 3 | 0 | 3 |
| ESYT1 | KCNMA1 | 0.689198 | 4 | 0 | 4 |
| ESYT1 | C17orf80 | 0.687182 | 4 | 0 | 3 |
| ESYT1 | ZNF496 | 0.685845 | 4 | 0 | 3 |
| ESYT1 | CTF1 | 0.683306 | 3 | 0 | 3 |
| ESYT1 | GRB2 | 0.680957 | 3 | 0 | 3 |
| ESYT1 | TATDN1 | 0.680376 | 3 | 0 | 3 |
| ESYT1 | TTLL7 | 0.677781 | 4 | 0 | 3 |
For details and further investigation, click here
