GRB2

 

Full name: growth factor receptor bound protein 2 Alias Symbol: NCKAP2
Type: protein-coding gene Cytoband: 17q25.1
Entrez ID: 2885 HGNC ID: HGNC:4566 Ensembl Gene: ENSG00000177885 OMIM ID: 108355
Drug and gene relationship at DGIdb
Screen Evidence:

 

GRB2 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04068FoxO signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04540Gap junction
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05211Renal cell carcinoma
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of GRB2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GRB2 2885 223049_at 0.5137 0.3183
GSE20347 GRB2 2885 215075_s_at -0.0275 0.8762
GSE23400 GRB2 2885 215075_s_at -0.0105 0.8414
GSE26886 GRB2 2885 223049_at -0.1435 0.4279
GSE29001 GRB2 2885 215075_s_at -0.1031 0.7638
GSE38129 GRB2 2885 215075_s_at 0.0843 0.5302
GSE45670 GRB2 2885 223049_at 0.1466 0.2075
GSE53622 GRB2 2885 65536 -0.0168 0.8090
GSE53624 GRB2 2885 65536 0.2478 0.0000
GSE63941 GRB2 2885 223049_at 0.0286 0.9249
GSE77861 GRB2 2885 223049_at 0.4684 0.1076
GSE97050 GRB2 2885 A_24_P407717 0.1190 0.6756
SRP007169 GRB2 2885 RNAseq 0.0158 0.9580
SRP008496 GRB2 2885 RNAseq -0.0208 0.9079
SRP064894 GRB2 2885 RNAseq 0.3511 0.0004
SRP133303 GRB2 2885 RNAseq 0.5313 0.0014
SRP159526 GRB2 2885 RNAseq 0.1245 0.6510
SRP193095 GRB2 2885 RNAseq 0.1401 0.1381
SRP219564 GRB2 2885 RNAseq 0.2223 0.4350
TCGA GRB2 2885 RNAseq 0.0707 0.1100

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by GRB2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GRB2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GRB2 2885 6 2 22
GSE20123 GRB2 2885 6 2 22
GSE43470 GRB2 2885 5 3 35
GSE46452 GRB2 2885 34 0 25
GSE47630 GRB2 2885 8 1 31
GSE54993 GRB2 2885 2 5 63
GSE54994 GRB2 2885 10 4 39
GSE60625 GRB2 2885 6 0 5
GSE74703 GRB2 2885 5 1 30
GSE74704 GRB2 2885 4 1 15
TCGA GRB2 2885 32 10 54

Total number of gains: 118; Total number of losses: 29; Total Number of normals: 341.  

 

Somatic mutations of GRB2:

 

Generating mutation plots.

 

Highly correlated genes for GRB2:

 

Showing top 20/328 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GRB2THAP50.821751303
GRB2ETV60.797641303
GRB2SLC25A190.794053303
GRB2WBP110.776324303
GRB2AP3M20.759369303
GRB2ARHGAP180.734873303
GRB2ALKBH60.722006303
GRB2MTMR40.716423404
GRB2MRPL30.712378303
GRB2MGAT4A0.71011303
GRB2ARFGEF20.706371303
GRB2DHTKD10.702169303
GRB2RNASEL0.700253303
GRB2ZFYVE270.699737303
GRB2IFIT50.698047303
GRB2FAF20.696691404
GRB2RRP360.69668303
GRB2PSD30.694503303
GRB2XPO10.691604403
GRB2SMAD40.69022303

For details and further investigation, click here